fel

[fel @_felicita96_]

@Indomaret min, aplikasi poinku emg lagi error ya? Gak bisa login daritadi dibilang sinyal bermasalah padahal sinyal udh full 4G+ di area Indonesia Timur sini. 🗿😒

[fel @_felicita96_]

@pln_123 ini ada hackers team gabut ngegangguin rute kelistrikan PLN ato gimana ya? 2 hari 2 malem >12 jam, padam terus listriknya dan lama bener reparasinya 🗿🗿 buset dah

[PT PLN (Persero) @pln_123]

Dear Electrizen, kami menghimbau untuk selalu berhati-hati terhadap segala jenis penipuan yg mengatasnamakan PLN123 baik di sosial media maupun di media lainnya. Kalau menemukan akun PLN 123 yg tidak resmi, mohon bantuannya untuk laporkan akun ya.

#Penipuan #AkunPalsuPLN123

[fel @_felicita96_]

@pln_123 Ngeprank banget yah kmrn malam. mati >1jam, begitu selesai lapor dan dpt tiket, ga lama lgs nyala. ehhh..... Tiba2 mati ulang subuh sampe pagi. Total >6 jam ya kamu padam PLN!!🗿
2 hari 2 malam mati listrik, org ga bisa ngapa2in. Menyebalkan sx!

[fel @_felicita96_]

@pln_123 Sdh dijawab min. Tolong cek

[Dr Ihab Suliman @IhabFathiSulima]

Excellent summary of Interleukins Functions.

[Inferam @InferamAI]

Anatomy of a neuron

[Running-Physio @tomgoom]

How can we enable and empower people back to running after knee surgery?
Findings from Alexander et al. (2025) in BJSM [PMID: 39904577]

[Dr. Filippo Cademartiri @FCademartiri]

🧬 Lactate Is Not Just a Waste Product — It’s a Mitochondrial Signal

For decades, lactate was considered a byproduct of glycolysis. This study flips that paradigm.

Cai et al. demonstrate that lactate directly activates the mitochondrial electron transport chain (ETC) — independently of its metabolism  .

⚡ What’s truly innovative?
🔹 Lactate stimulates oxidative phosphorylation (OXPHOS) without being converted to pyruvate.
🔹 Both L- and D-lactate activate mitochondrial respiration — meaning this effect is LDH-independent.
🔹 Lactate directly enters the mitochondrial matrix, independent of the mitochondrial pyruvate carrier.
🔹 ETC activation increases mitochondrial NAD⁺/NADH ratio and ATP production.
🔹 This shifts cells from glycolysis toward mitochondrial ATP synthesis (a reversible “anti-Warburg” effect).

In other words: lactate is a mitochondrial messenger.

🧠 Mechanistic insight
Rather than acting purely as a carbon fuel, lactate enhances ETC activity first. PDH activation and increased TCA flux follow as secondary effects. Importantly, this requires oxygen and a functional ETC.

🔥 Functional consequences
• Suppresses glycolysis
• Reduces mitochondrial reductive stress and ROS
• Enables proliferation under respiratory stress
• Rescues cells with partial complex III defects
• Enhances CD8⁺ T-cell proliferation and interferon-γ production

💡 Take-home messages
1️⃣ Lactate regulates the balance between glycolysis and OXPHOS.
2️⃣ The mitochondria can “sense” lactate availability.
3️⃣ D-lactate enhances respiration without cytosolic redox stress.
4️⃣ Therapeutic implications may extend to cancer, immunotherapy, mitochondrial disease, and metabolic dysfunction.

Lactate is not metabolic waste.
It’s a bioenergetic signal.

[nervemed @nervemed]

IV Fluids Guide

[Dr sthanu subramanian @drsthanus]

Stroke Management Algorithm.

https://t.co/WE5ZvJoVo5

[Nick Ilić @NickIlic_Physio]

1/
New research review out now: The Sacroiliac Joint: Complex Pain, Simple Truths 👇
https://t.co/5SpYILbHqG

SIJ pain is real, common, and often misunderstood — and simple biomechanical myths still cloud clinical reasoning.
Covering this 2025 Article: https://t.co/8AmqNqqEf5

[Prehab®�� @ThePrehabGuys]

ANKLE SPRAIN REHAB

Exercises:
✅ Ankle dorsiflexion
✅ Ankle eversion (band)
✅ Ankle inversion
✅ Ankle dorsiflexion stretch
✅ SL heel raise (eversion)
✅ SL heel raise (inversion)
✅ SL balance on toes
✅ SL RDL - ball toss
✅ Drop jump
✅ Lateral bound
✅ Single leg hop

[dr. Adam Prabata @AdamPrabata]

Gua Baru Tahu Sering Nonton Short Video Bisa Bikin Fungsi Otak Menurun

Awalnya gua kira nonton short video di HP itu cuma buang-buang waktu. Tapi setelah baca jurnal ini, gua baru tau efeknya bisa berbahaya untuk otak.
Penelitian dari Tiongkok ini meneliti 48 orang, terus dilihat kebiasaan mereka nonton short video, lalu dicek fungsi atensi & kontrol diri, didukung juga dengan pemeriksaan EEG.

Hasilnya bikin gua cukup bikin kaget antara lain:
-Semakin sering nonton short video, semakin turun kemampuan otak buat kontrol diri
-Fungsi eksekutif otak, terutama atensi, juga menurun

Short video itu juga berasosiasi dengan overstimulasi dengan karakteristik cepat, singkat, dan penuh reward instan. Lama-lama otak jadi kebiasaan butuh stimulus cepat, sehingga bikin fokus jangka panjang makin susah.

Yang menarik dari studi ini adalah:
Semakin tinggi tingkat kecanduan (adiksi) untuk menonton short video di smartphone, berasosiasi dengan semakin rendah tingkat pengendalian diri (self control)

KESIMPULAN:
Kebiasaan nonton short video ternyata berkaitan dengan penurunan self-control dan turunnya fungsi eksekutif otak, terutama kemampuan atensi.

[Koruptor itu Pencuri @ekopi991882]

@AymanAlatas Ivermectin bisa dipakai obat kanker

[Nortriptyliney @Nortriptyliney]

@AymanAlatas + gajinya sesuai. Bukan dibayar seikhlasnya. Ini profesi, bukan baksos seumur hidup

[Ayman Alatas @AymanAlatas]

Negara butuh dokter tapi ya dokter yang berkompeten

[fel @_felicita96_]

@pln_123 Min, buset dah.
Gto dan sekitarnya yg nembus sampe sebagian kota mdo. 🗿 plis deh.
Eneg bgt 3th, gak ada perbaikan sistem kerja dan solusi dari PLN indo, buat alur sistem kelistrikan dan kabel2 menjuntai2 utk area pulau K bercapeo nih.🗿🗿

[moka 🍰 hiatus @mocapoca_]

my dad was a physics teacher in a top school in jakarta, where almost 80% of its attendees go to top schools abroad.

He published books, worked multiple jobs.

But he had to cry in the kitchen bc at the time he didnt have the heart to tell me that he couldnt even afford my uni.