Learn about how Dr. Ostrowski is researching how the immune system interacts with HIV and is trying to develop a an HIV therapeutic vaccine
📝by Jennifer Ma (@_jenniferma_)
🖌️ by Anne McGrath (@stellalunaa__)
#HIV#Vaccine
Dr. Mario Ostrowski, infectious disease physician and researcher at St. Michael's Hospital, is borrowing techniques from the COVID-19 vaccine to develop an HIV therapeutic vaccine. Read about his work in @IMSMagazine: https://t.co/R5fk6mvHNo
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Microglia [in Alzheimer's disease patients] displayed higher glucose uptake than neurons and astrocytes...indicating that the cerebral glucose uptake in humans is also strongly influenced by microglial activity"
https://t.co/2GZzua3mi8
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Mice with UTI demonstrated significantly greater impairments in frontal and hippocampus-mediated behaviors...while treatment with systemic anti-IL-6 fully reversed these functional impairments."
https://t.co/5LvGTkNxmG
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Male, but not female mice born to dams immunized with the extracellular portion of Caspr2, [which targets maternal IgG antibodies,] show an ASD-like phenotype...[increased microglial activation was also observed]"
https://t.co/uahDAH3Y6a
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "We define ‘microglia inflamed in MS’ and ‘astrocytes inflamed in MS’, glial phenotypes that demonstrate neurodegenerative programming...[and] identify complement component 1q (C1q) as a critical mediator of microglial activation"
https://t.co/Bj9C33zEiH
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Key secondary imaging analyses...suggest that teriflunomide might have beneficial effects in children with relapsing multiple sclerosis by reducing the risk of focal inflammatory activity"
https://t.co/XoQGnr0e1x
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD"
https://t.co/yR78L3PTly
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "The brain can store and retrieve specific immune responses, extending the classical concept of immunological memory to neuronal representations of inflammatory information"
https://t.co/yd59XH9GKt
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Unlike most other infections, influenza was associated with Parkinson disease more than 10 years after infection...[indicating that] influenza infection may increase long-term risk of developing Parkinson disease."
https://t.co/yMS0L5YyRY
#4BB3neuroimmune
@hthsci4bb3@hthsci4bb3 EVIDENCE: "Amyloid-related imaging abnormalities, [manifesting as brain edema], were the most was the most common adverse event [for patients treated with aduhelm], with 73.7% [of patients experiencing an event] within the first 8 doses"
https://t.co/nYv4Dt8Elb