Sam Chamberlain

Postdoctoral Research Associate in the Higgins Lab, University of Oxford. Structural biologist in host-pathogen interactions.

[Waggoner Lab @LabWaggoner]

Both inhibitory and activating KIRs recognize RIFINs: a dual-edged mechanism of NK cell control in malaria
@sigtrans_sttt @angelica_cuapio
https://t.co/7plS2S0f8r
comment on @Nature
https://t.co/h6zI4cj9BX

[Matt Higgins @ParasiteMatt]

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism!
https://t.co/T4hjaHnedb

[Immunology of Infectious Disease News @infdisease_news]

🎮 Researchers demonstrated that activating killer immunoglobulin-like receptors can recruit NK cells to target a pathogen and reveal a potential role for activating immune receptors in controlling #malaria infection.

@Nature | https://t.co/lXmtZMSLmt

[Sam Chamberlain @_SChamberlain_]

All that 'networking' has me tired!
Great week of talks/posters and loved meeting more of this fantastic community! #EMBLmalaria

[Clinton Lau @CKYLau]

Leaving another BioMalPar with new ideas, new perspectives and new friends. Thanks to @sabrina_absalon, @TacoKooij, @jessmbryant and @Fredros_Inc for organising a fab conference! Heading home now with @ParasiteMatt, @AmabilinoBrian and a sleepy @_SChamberlain_. #EMBLMalaria

[Matt Higgins @ParasiteMatt]

Very proud of @nawsad_alam, giving his talk about how we are trying to make the best possible blood stage malaria vaccine at BioMalPar 2024

[Sam Chamberlain @_SChamberlain_]

Always important to network into the wee hours...
#EMBLMalaria @EMBL

[Sam Chamberlain @_SChamberlain_]

Read about a fascinating evolutionary battle between the malaria parasite and the human host in our new pre-print below!
Parasites have evolved to bind to inhibitory immune receptor KIR2DL1 while the host has a counter-offensive trick up its sleeve...

https://t.co/7AFWrVB3nP

[Matt Higgins @ParasiteMatt]

Our latest preprint reveals an amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind to inhibitory KIR receptors and suppress immune cell function while humans evolved activating KIR receptors to bind these RIFINs to kill parasites!

[Sam Chamberlain @_SChamberlain_]

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65 https://t.co/9yqIpEcXNL