Nawsad Alam

Structural vaccinologist designing malaria vaccines; postdoc in Higgins Lab, University of Oxford

[Matt Higgins @ParasiteMatt]

Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.

[Matt Higgins @ParasiteMatt]

Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them.
https://t.co/hGGnAnjqlI

[Matt Higgins @ParasiteMatt]

Delighted to share the final version of Richard Zhou's study on how the CD163 scavenger receptor cleans up after toxic haemoglobin spills out from our blood cells. An amazing grabber mechanism!
https://t.co/T4hjaHnedb

[Matt Higgins @ParasiteMatt]

Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!

[Matt Higgins @ParasiteMatt]

Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us??
https://t.co/KZMGLmTGI3

[Nawsad Alam @nawsad_alam]

It was great to share my work on designing RH5top - really appreciated the engagement. Huge thanks to the organizers for the opportunity!

[Matt Higgins @ParasiteMatt]

@nawsad_alam presented our structure-guided design of RH5top, our latest blood stage-malaria vaccine immunogen in talk and poster at the Malaria Gordon conference. The culmination of many studies from the lab and doing well in pre-clinical testing! More soon.

[Matt Higgins @ParasiteMatt]

Another job available in our team! We are seeking a project manager to help us to manage our malaria vaccine development projects. See here:
https://t.co/ZIsiBkHokL

[Nawsad Alam @nawsad_alam]

An incredible chance to be part of impactful work!

[Matt Higgins @ParasiteMatt]

We have a position available for a research assistant to join our team to test our rationally designed malaria vaccines. A fun job with a lovely team of people and an important project funded by the Gates Foundation. Come and join us!
https://t.co/m3nZQNw1jH

[Matt Higgins @ParasiteMatt]

Read all about it in our preprint:
https://t.co/Cza8JupVi2

[Eric Topol @EricTopol]

The capability for producing "mirror life" is out there and poses danger. When some scientists who worked on this became aware, they stopped pursuing it, and co-authored this piece, along with over 30 leading scientists—a @ScienceMagazine policy forum that lays out the risks
https://t.co/ud23zfG3o2

[Nawsad Alam @nawsad_alam]

@GntlmnScientist @befcorreia @MartinPacesa PROSS, from Sarel Fleieshman's lab is a good example.

[Nawsad Alam @nawsad_alam]

One of my favourite proteins! It’s fantastic to see how structure-guided approaches are producing such impressive results!

[Matt Higgins @ParasiteMatt]

Thanks @TrendsParasitol for highlighting our structure-guided design of PfRH5-based vaccines. In particular, PfRH5.2 which combines truncations from Wright et al (2014) and mutations from Campeotto et al (2017). Good to see it outperforming PfRH5.1!
https://t.co/6ZtSw87mGc

[Matt Higgins @ParasiteMatt]

Thanks @TrendsParasitol for highlighting our structure-guided design of PfRH5-based vaccines. In particular, PfRH5.2 which combines truncations from Wright et al (2014) and mutations from Campeotto et al (2017). Good to see it outperforming PfRH5.1!
https://t.co/6ZtSw87mGc

[John Peters @johnthejack]

Scotland has detected no cases of cervical cancer in women born between 1988-1996 who were fully vaccinated against HPV between the ages of 12 and 13.
https://t.co/clCeKqILrP

[Kavli Institute for Nanoscience Discovery, Oxford @KavliOxford]

#MeetTheResearcher
Introducing @nawsad_alam from Professor Matt Higgins' lab. As a postdoctoral researcher, Nawsad uses structure-guided approaches to design effective blood-stage #malaria vaccine candidates.

[Eric Topol @EricTopol]

Just out @NatImmunol
A single infusion of engineered T cells put asthma in long term remission in the mouse model
https://t.co/mrStuko6nA

[Nawsad Alam @nawsad_alam]

Presenting this work malaria blood stage vaccine design and interacting with other attendees was a great experience. @EMBLEvents #EMBLMalaria #BioMalPar2024

[Matt Higgins @ParasiteMatt]

Very proud of @nawsad_alam, giving his talk about how we are trying to make the best possible blood stage malaria vaccine at BioMalPar 2024

[Demis Hassabis @demishassabis]

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial https://t.co/Gs4GoOB3fD

[Nawsad Alam @nawsad_alam]

Excited to unveil this study aimed at deepening our comprehension of epitope-focused vaccines targeting blood-stage malaria... #malaria #vaccines

[Matt Higgins @ParasiteMatt]

This immungen elicited a high-quality growth inhibitory response. We also showed that a first dose of this highly focused immunogen, followed by subsequent doses of the broader immunogen, PfRH5, was most effective. Read all about it here:
https://t.co/342QdtiM1s

[Alejandro Montenegro @aemonten]

"A true mentor is someone who has more imagination about you than you have about yourself"

https://t.co/k6XWy2Cf7L