Alexander Lisinski

PhD in psychopharmacology, University of Gothenburg. Resident psychiatrist, Sahlgrenska University Hospital.

[Bertoglio lab (FMC/UFSC) @bertogliolab]

Psilocybin Elicits a Conserved Glucocorticoid-Responsive Gene Signature Across Five 5-HT2A Receptor-Rich Brain Regions in Rat
https://t.co/or42klwsdE

[Alexander Lisinski @a_lisinski]

@page_eco Sadly this is the case also on the other side of the world. One could think that the University of Gothenburg, Sweden, isn’t already losing money, when looking at their building projects.

[Alexander Lisinski @a_lisinski]

Just 9 days to go until the highlight of psychedelic science in the Nordic countries this year 🌟

Looking very much forward to welcoming Guy Goodwin, Julie Holland, Matthew W Johnson and many others in Stockholm!

https://t.co/UoajSWXN4Z

[Alexander Lisinski @a_lisinski]

Almost a year has passed since we published our letter detailing severe errors in this meta-analysis on psychotherapy, antidepressants, and suicide.

What has happened since then? Absolutely nothing! The journal from @CambUP_Psych refuses to correct or retract the original paper.

[Alexander Lisinski @a_lisinski]

Does combined treatment with antidepressants and psychotherapy really cause twice as many suicide attempts than psychotherapy only?

This was the conclusion of a recent meta-analysis published in Psychological Medicine. Me and @f_hieronymus took a closer look…thread below 🧵

[Alexander Lisinski @a_lisinski]

@ProfRobHoward @Macbeth4183781 @AnnaSylwes94870 Neither have I seen anyone ask PCI operators, brain surgeons, or oncologists try their treatments on themselves. Of course - this isn’t psychiatry, so it doesn’t attract the same criticism.

[Fredrik Hieronymus @f_hieronymus]

Is psilocybin as effective for depression as it seems?

In a new meta-analysis we look at outcomes after treatment with three types of antidepressants: psilocybin, esketamine and SSRIs. Compared to their own control groups, psilocybin (ES/SMD: 0.70) is clearly more effective ->

[Alexander Lisinski @a_lisinski]

@psybalazs For me, the argument is stronger, in that this is an effect size of a treatment widely perceived as good enough for depression, rather than trying to relate this to theoretically distinguishable between-group differences.

[Alexander Lisinski @a_lisinski]

@psybalazs With that said, I would select for example the SSRI-placebo difference, which in size is similar to the MCID for the HDRS, and relate any possible superiority of treatment to this effect size difference.

[Alexander Lisinski @a_lisinski]

@psybalazs Disregarding this, I would nonetheless prefer a drug that is 2.9 points better on the HDRS that I only had to take once.

[Alexander Lisinski @a_lisinski]

@psybalazs Very clever approach, which certainly shines new light on PAT. Besides agreeing with some other comments here, I do however have to point out that the MCID is an inter-individual measure, not a between-group measure.

[Alexander Lisinski @a_lisinski]

Call for abstracts now open for Borealis Psychedelic Science Summit in Stockholm September 26-27th. Take your chance to present your research for leading international and Nordic researchers!

https://t.co/N0YQQ00yz1

[Alexander Lisinski @a_lisinski]

@psybalazs With that said, I would not mix these methods in one paper unless I had a very good reason to do so.

[Alexander Lisinski @a_lisinski]

@psybalazs My opinion after doing similar analyses on large SSRI/SNRI datasets is that when n gets large enough, there are only minor differences between baseline- and delta-based methods. My guess is that your results were divergent because you only had data from one trial.

[Alexander Lisinski @a_lisinski]

Vi kommer arrangera öppna möten i vår partilokal i centrala Göteborg, med start redan nu på onsdag 2/1. Föranmälan är önskvärd men ej obligatorisk. Är du intresserad av att komma vid ett senare tillfälle eller vill veta mer, kontakta mig gärna här på X.

https://t.co/G2eyw0AWea

[Alexander Lisinski @a_lisinski]

Är du också trött på hur sjukvården styrs i Västra Götaland? Göteborgs och VGR:s lokala parti Demokraterna söker nu engagerade, gärna med erfarenhet av hälso- och sjukvård, för att forma en ny politik för vår region.

[Nicholas Fabiano, MD @NTFabiano]

Nearly 3 years ago, this controversial study claimed that there is “no consistent evidence of there being an association between serotonin and depression”.

It has been read >1,000,000 times.

Here’s what the evidence actually shows.

🧵1/17

[Alexander Lisinski @a_lisinski]

Skriver i GP debatt idag tillsammans med kollegor från Demokraterna. Vi blir först med att ta ställning för att skrota Millennium. Hoppas på likadana ställningstaganden från övriga partier snarast.

https://t.co/afzDBpfNev