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@AdhesionLab@thattai This was an amazing learning experience that taught me the ins and outs of going from raw experimental data, to model building, and to using that model to answer an interesting question. Do check out our paper! 3/3
Glycans -- tree-shaped sugar chains that stick out of eukaryotic cells -- perform many functions at the cell surface essentially making multicellularity possible. One of their functions is to convey information about the cell it is on to its surroundings. 1/3
Preprint alert (1/n)
This study uses loss-of-adhesion-driven Golgi disorganization to generate a highly reproducible gradient of Golgi phenotypes and measure cell-surface glycans in single cells using two fluorescently tagged lectin probes (ConA and WGA).
https://t.co/xVbPrWbafS
A cell already en route to one fate, retains awhile the ability to respond to alternate signals and adopt alternate fates.
But till what point in their journey can they still change lanes? Is it possible to pinpoint this "competence window" and perhaps, even modulate it?
@realRihellab@NeuroSchnell Recommend “Bobby Fischer Teaches Chess”, it’s on this list as well. Starts from rules and works its way up to mate in 1, 2, 3 moves and other useful strategies and exercises.
“The big lesson to learn here is that in science, only mathematics is the art of the perfect. Physics is the art of the optimal, and biology is the art of the satisfactory: if it works, you keep it; if it doesn’t, you get rid of it" -- Sydney Brenner
https://t.co/apnsnb0p0A
The common housefly can land on almost any surface – horizontal, vertical, and even upside-down – in less than the blink of an eye. Ever wondered how?
Now we know. Read more: https://t.co/cRy4S0QjSe
When Sonia Vallabh lost her mother to a rare disease, she and her husband, Eric Minikel, set out to find a cure.
“Now that you’ve heard everything, do you think we’re going to make it?”
https://t.co/KU4A62Lp4O