Ali Azargoonjahromi

"Throughout my life, I strive to conserve my conviction in the face of my rancour." Google Scholar:

[Ali Azargoonjahromi @aazargoonj]

There is no greater sorrow than not being able to find someone to talk to ...

[Ali Azargoonjahromi @aazargoonj]

#Microgravity-related exposure was associated with ventricular enlargement, #brain displacement, CSF redistribution, region-specific brain changes, sensorimotor decline, and biomarker alterations.

https://t.co/IKbLxwHWGM

[Ali Azargoonjahromi @aazargoonj]

NF-κB has context-dependent roles in Alzheimer’s disease (AD): transient signaling may support neuronal protection, whereas persistent RelA/p65-driven activation promotes amyloid pathology, neuroinflammation, tau propagation, and neurovascular injury.

https://t.co/kfWVYG4AWp

[Ali Azargoonjahromi @aazargoonj]

In mild cognitive impairment (MCI), higher plasma and CSF amyloid-β42 (Aβ42) predicted rising plasma #sortilin, while higher sortilin was linked to reduced whole-brain volume and poorer cognition.

https://t.co/xP5AxDQZqe

[Ali Azargoonjahromi @aazargoonj]

#Sleep disturbances in #schizophrenia (SCZ)—including shorter sleep, prolonged sleep onset, and reduced slow-wave sleep—were associated with poorer cognition, greater #psychiatric symptom severity, worse functioning, and lower quality of life.

https://t.co/h69VrrwRhY

[Ali Azargoonjahromi @aazargoonj]

In mild cognitive impairment (MCI), higher p-cresol sulfate (p-CS) and TNF-α were associated with increased TNF receptor 2 (TNFR2), which mediated better cognitive performance, highlighting a potentially neuroprotective p-CS–TNF-α–TNFR2 axis.

https://t.co/2FLkGqPi8f

[Ali Azargoonjahromi @aazargoonj]

Higher CSF amyloid-β42 (Aβ42) was associated with greater cerebral glucose metabolism and better cognition in mild cognitive impairment (MCI) and Alzheimer’s disease.

In MCI, CSF Aβ42 was linked to fewer #neuropsychiatric and #depressive symptoms.

https://t.co/H4fl9xoWfm

[Ali Azargoonjahromi @aazargoonj]

Higher plasma #tryptophan was associated with larger bilateral #hippocampal volumes and better cognition in mild cognitive impairment (MCI), with hippocampal integrity mediating the tryptophan–cognition relationship.

https://t.co/EJu65KWqIm

[Ali Azargoonjahromi @aazargoonj]

Higher CSF GAP-43 was linked to greater cognitive impairment and amyloid-β (Aβ) accumulation in mild cognitive impairment, while this relationship reversed in Alzheimer’s disease dementia, suggesting a disease-stage-dependent role.

https://t.co/kpqqakkrsR

[Ali Azargoonjahromi @aazargoonj]

#Resveratrol (RV) consistently enhanced #neurogenesis in the hippocampus and subventricular zone in animal models, with potential benefits for cognition, mood regulation, stress resilience, and neuroprotection.

https://t.co/HTYNWXSMSx

[Ali Azargoonjahromi @aazargoonj]

Higher #serotonin levels were associated with larger total brain and #hippocampal volumes and better cognitive function in #Alzheimer’s disease (AD), supporting a potential #neuroprotective role for serotonin.

https://t.co/8eLPb0AphL

[Ali Azargoonjahromi @aazargoonj]

#Gantenerumab effectively reduced #amyloid-β (Aβ) burden in #Alzheimer’s disease (AD) through Aβ disaggregation and enhanced microglial clearance, but this biomarker improvement did not translate into a meaningful reduction in cognitive decline.

https://t.co/x6i7hZ34pK

[Ali Azargoonjahromi @aazargoonj]

#Amyloid-β (Aβ) appears to have a context-dependent role: physiological levels may support brain #homeostasis, whereas excessive accumulation drives synaptic dysfunction, neuroinflammation, and #neurodegeneration in #Alzheimer’s disease (AD).

https://t.co/szf9vK748E

[Ali Azargoonjahromi @aazargoonj]

#KarXT (xanomeline–trospium) improved #schizophrenia symptoms and cognitive function, while trospium helped limit peripheral cholinergic side effects. These findings support muscarinic M1/M4 signaling as a promising non-dopaminergic treatment strategy.

https://t.co/ujraj3Yqqz

[Ali Azargoonjahromi @aazargoonj]

Lower serum #zinc levels were associated with #anxiety, while higher zinc intake was linked to lower anxiety, supporting a potential beneficial role for zinc in anxiety management, although stronger evidence is needed.

https://t.co/L2hW9bgz8T

[Ali Azargoonjahromi @aazargoonj]

#Resveratrol showed promising effects in #Alzheimer’s disease, including improved cognition, reduced Aβ accumulation and neuroinflammation, and enhanced #neuroprotection.

@Anders_19a

https://t.co/OKkAgEqsgG

[Ali Azargoonjahromi @aazargoonj]

#SARS-CoV-2 may contribute to neurological symptoms through #neuroinflammation, vascular dysfunction, and blood–brain barrier disruption.

Key implication: these pathways may help explain the neurological burden of #COVID-19.

https://t.co/uHY0k6zHjv

[Ali Azargoonjahromi @aazargoonj]

#Epigenetic mechanisms may link genetic susceptibility and environmental stress to #anxiety disorders by altering gene regulation. Key implication: targeting maladaptive epigenetic changes may offer new strategies for anxiety treatment.

https://t.co/p1JhiUw6E1

[Ali Azargoonjahromi @aazargoonj]

Nitric oxide (NO) has a dual role in Alzheimer’s disease: excess NO may promote neurotoxicity, while physiological NO supports neuroprotection and memory. Key implication: restoring NO balance may be more beneficial than broadly suppressing NO signaling.

https://t.co/GVHIQQnaqq

[Prof. Feynman @ProfFeynman]

You will never live if you are looking for the meaning of life. Fall in love with some activity and do it! Nobody ever figures out what life is all about and it doesn't matter.