BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS

Consultant Haematologist & Director Haemophilia Centre,Glan Clwyd Hospital, Sarn Lane, Bodelwyddan, Rhyl#

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

A haematologist's dream just came true.
For years I wanted one place to manage warfarin properly. TTR calculations. Drug interactions. BSH guidelines. PCC dosing. BNF reference. All scattered across PDFs and bookmarks and memory.
So I built it myself.
https://t.co/oMAh2PKOvs
Its Live Now !
Free. No login. Works on your phone. Works offline.
What's inside:
Rosendaal TTR Calculator for 6 indications with GRADE-rated recommendations
Drug Interaction Checker with 40+ drugs, CYP mechanisms, and severity ratings
5 BSH Guidelines with collapsible GRADE recommendations
BNF Monograph and NICE CKS reference
4-Factor PCC Dose Calculator
But this is just Step 1.
The real dream is a full Thrombosis Management Suite. VTE risk assessment. DOAC dosing. Cancer-associated thrombosis. HIT protocols. Antiphospholipid syndrome. Thrombophilia guidance.
All evidence-based. All free. Built by a clinician at the bedside.
#BloodDoctor #Warfirin #Anticoagulation #ISTH #bsh
https://t.co/oMAh2PKOvs

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/g0HWO4A3YN

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/McMrPgn3lh

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/kCN4u07XIE

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/dCT9e0GEWU

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/wwfWllYdaf

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/elydbAidaG

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/2BQs6yVrjl

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/0ab0p8eB1d

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/MpZI1oUklR

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/SUWXU0kkJQ

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

https://t.co/BoxXtneKvu

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

Blood🩸Doctor:  4 Life-or-Death Secrets Hidden in a Sickle Cell P... https://t.co/MzIh6Mbr2x

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

@WilliamAird4 Macrocytosis

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

(The Summary): Here is a quick reference card I made for the residents summarizing the Morphology, Flow, and Risk Stratification.

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

(The Hook): t(8;21) AML: The "Favorable Risk" leukemia... with a catch. 🧬
We teach postgrads that t(8;21)(q22;q22) is a "Good Risk" entity. But the molecular details determine who stays in remission and who relapses.
A #BloodDoctor thread on the pearls you need to know. 🧵👇 #Haematology #MedEd #AML

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

The Management):
📉 MRD is King Initial response is good, but depth is better.
Target: >3-log reduction of RUNX1-RUNX1T1 transcripts by end of Cycle 2.
🗓️ Rule: Monitor MONTHLY in Year 1. These clones have a short doubling time. Don't wait 3 months!

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

Tweet 4/4: The Clinical Takeaway
For optimal patient safety, ensure your lab uses an assay that directly assesses the VWF-GPIb interaction. A "normal" VWF:Ab result on caplacizumab does NOT mean VWF function is restored. It means the assay is failing to monitor the drug's effect. Teach your registrars the mechanism! #MedEd #Coagulation

[BLOOD 🩸Doctor - Dr Abdul Mannan FRCPath, FCPS @abdulmannan74]

Tweet 1/4: The Core Problem
🚨 LAB ALERT for Haem Docs! 🚨 Treating iTTP with caplacizumab? Your VWF activity assay choice is critical for monitoring and managing bleeding. The wrong test can yield misleading results and compromise care. #Haematology #iTTP
https://t.co/emmvTEStO5