Our new paper on AAV capsid engineering for gene therapy in the brain from the @sabeti_lab is now out at @MedCellPress. Check it out here: https://t.co/1qZKQgcMbr
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ONLINE NOW! Stanton et al. @sabeti_lab introduce a class of primate-derived engineered AAV capsids with therapeutic potential because of their increased brain transduction and reduced tropism for the liver and other peripheral organs in macaques:
https://t.co/HCyYrEYHfl
In a nutshell, our work represents an important step towards gene therapy in the brain in humans, and the PAL family has highly favorable characteristics for clinical use. Refinement of this family may result in increased potency and translation across species.
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