el

brain dump
:p

[el @acerbose]

mlb bigla nalang naluluha 🧍🏻‍♀️

[el @acerbose]

bisphosphonates (-dronates)
counseling:
- upright for 30 mins after dose
- taken in the morning after waking up
with PLAIN water, NOT taken w food

[el @acerbose]

statins
- inhi. HMG-CoA reductase
- best taken @ NIGHT - peak cholesterol synthesis
EXCEPT Atorvastatin, Rosuvastatin (long acting)

*PCOG
HMG-CoA reductase - RLE of MVA pathway (@ cytosol)

[el @acerbose]

NAPQI → N-acetyl-p-benzoquinOne imine

[el @acerbose]

SJS → Stevens–Johnson syndrome

TB-DOTS → Directly Observed Treatment, Short-Course

PhilPSP → Philippine Practice Standards for Pharmacists

[el @acerbose]

Sieve # → Square Openings per Linear Inch

PSIG → Pounds per Square Inch Gauge

PIC/S Guidelines → Pharmaceutical Inspection Co-operation Scheme

[el @acerbose]

hydralazine
- gestational HTN/preggy (MHLN)
- arteriolar vasodilator (with ISDN, unloader med for HF)
- S/E: lupus-like syndrome 🦋

[el @acerbose]

β-blockers arrythmia drug class 2
EXCEPT SOTalol (class 3)

[el @acerbose]

propranolol
- nonselective β-blocker (NSTP)
- for stage fright (performance anxiety)
- migraine prophylaxis
- for hypErthyroidism (inhi. peripheral conversion)

[el @acerbose]

TIMolol,BETAXolol - glaucoma

[el @acerbose]

🟢⚪️ green & white hellebore — steroidal alkaloids
⚫️ black hellebore — cardiac glycoside

european mandrake (mandragora) — tropane alkaloid
american mandrake (podophyllum) — resin

[el @acerbose]

hemoglobin
- globular protein
- 4 polypeptide chains with heme containing a ferrOUS (Fe+2) ion

[el @acerbose]

rough er - protein synthesis
smooth er - lipid synthesis

[el @acerbose]

amphoteric - can act as both acid and base

amphipathic - has both hydrophilic and hydrophobic regions

amphiPROtic - can accept or donate protons

amphiBOLic - involved in both catabolism and anabolism

[el @acerbose]

Carrageenan
kappa and iota - gelling
lambda - non gelling, thickener

[el @acerbose]

Nutgall
- tannic acid (gallic acid & ellagic acid)
- excresence from the TWIGS of Quercus infectoria when the INSECT Cynips tinctoria deposits its ova

[el @acerbose]

Yerba Santa / Eriodictyon
Eriodictyol
- mask bitter taste by paralysis of taste buds
- a resin

[el @acerbose]

LIQUORICE (Glycyrrhiza glabra)
Glycyrrhyzin
- mask taste of bitter drugs (due to sweetness)
- increases the foaminess of beer
- for Addison's dse
- C/I in px with HTN (causes fluid/Na+ retention)

[el @acerbose]

👆 Saponin glycoside

[el @acerbose]

cysteine
- keratin (forming its disulfide bonds)
- glutathione

proline
- tensile strength of collagen

lysine
- collagen crosslinking (makes it insoluble in solvents that disrupts HB)

[el @acerbose]

Anaerobic
Pyruvate (Pyruvate DEcarboxylase) → Acetaldehyde → Ethanol

Pyruvate (LACTATE dehydrogenase) → Lactic acid

[el @acerbose]

Pyruvate (Pyruvate dehydrogenase) → Acetyl-CoA

Pyruvate (Pyruvate carboxylase) → OAA

[el @acerbose]

Replication: DNA → DNA
Transcription: DNA → RNA
@ nucleus, mitochondria

Translation: RNA → proteins
@ cytosol