If anaphylactic shock is not responding to epinephrine, always ask one question:
"Is the patient taking a β-blocker?"The answer may lead you to the life-saving adjunct: IV glucagon.
💊 SGLT inhibitors for HF (irrespective of EF)
🚀 Ultra-rapid clinical benefits
❤️🩹 Benefits >>potential risks
⬇️ CV☠️/HF🏨
⬆️ HRQoL
��� Amazing value
$60 a year in med costs ▶️
$2500 a year in ⬇️🏨s savings
✅ Start now
From Food to the Cells: Vitamin B12 Absorption
1️⃣ B12 in Food
Vitamin B12 in your food like Meat, Fish & other animal products are tightly bound to Proteins.
It cannot be Absorbed yet.
2️⃣ Stomach acid frees B12
Stomach Acid (HCL) & Pepsin breaks down the protein & frees B12.
At the same time, your stomach releases something called the Intrinsic Factor (IF).
3️⃣ Haptocorrin grabs B12
B12 then binds to another protein called Haptocorrin present in saliva & gastric secretions.
Think of Haptocorrin as B12’s bodyguard, it protects the vitamin from being damaged by stomach acid.
4️⃣ Intrinsic factor gets hold of B12
As B12 enters the small intestine, pancreatic enzymes digest Haptocorrin & release B12 once again.
Now B12 binds to Intrinsic Factor (IF), forming the B12 Intrinsic Factor complex.
This is the only form that can be efficiently absorbed.
5️⃣ Absorption in the Ileum
In the last part of the stomach (ileum), there are receptors that can detect B12-IF complex.
In the intestinal Cells, IF is discarded & B12 enters the blood stream.
This is what you get when you test for serum Vitamin B12.
6️⃣ Delivery to the Cells
Some of the Vitamin B12 in the serum bind to transcobalamin (carrier protein) for Cellular uptake.
This is what you get when you do the Active B12 or the Holotranscobalamin test.
7️⃣ Storage in the liver
The liver stores B12 (around 2-5ug) as
- Adenosylcobalamin
- Methylcobalamin (Small amount)
The liver doesn’t just store B12, it also recycles it.
The liver secretes 5–10 ug of B12 per day into bile.
What makes a person B12 deficient inspite of having a B12 rich diet?
❌ Low stomach acid (B12 doesn’t free properly from food)
❌ Lack of Intrinsic factor (Autoimmune, Chronic atrophic gastritis, Genetic disorder etc)
⚠️ Intramuscular injection works best here
❌ Ileal disease like Crohns or surgery that prevents absorption
❌ Pancreatic disease (Cannot free from Haptocorrin)
❌ Certain Meds (ex Metformin reduces ileal absorption, PPIs suppress acid)
Muehrcke’s sign.
Muehrcke's Lines.
Hypoalbuminemia.
Seen in..
Autoimmune, inflammatoryNephrotic syndrome, glomerulonephritis, liver disease
Paired, transverse, narrowed white bands that run parallel to the lunula of the nails and are seen in patients with hypoalbuminemia.
Dr Robert Muehrcke first described this novel clinical finding in an article published in the British Medical Journal in 1956.
Image:
https://t.co/UZMdozmUZv
الهايبوناتريما ما تخلص !
مين قد سمع في ال Lipoprotien X
معلومتين تقدرون تستخدمونها في الراوند:
- يسوي pseudohyponatremia - يعن�� ال osmolality نورمال
- نشوفها في obstructive liver disease