Dr. Annemieke Kavelaars

Neuroimmunologist, studying chemotherapy-induced neurotoxicities at MD Anderson Cancer Center. Views are my own.

[Barack Obama @BarackObama]

It’s been a year since the Supreme Court overturned Roe v. Wade. Since then, 14 states have banned most abortions, leaving millions of women and girls with nowhere to turn for the care they need.  

And yet, there are reasons to hope. 

After Roe v. Wade was overturned, voters in Michigan, California, and Vermont helped enshrine abortion rights in their state constitutions. And governors in states like Nevada, Hawaii, and Pennsylvania have signed executive orders to protect abortion access.

[Dr. Annemieke Kavelaars @akavel]

@GeoffroyLaumet @ish1789 @JulietMwirigi @dianatavf @mike_doc_B @UTDPainLab Couldn’t agree more!!

[Dr. Annemieke Kavelaars @akavel]

@Eijkelkamp_N @CTI_UMCUtrecht @IenI_UMCUtrecht @UMCU_Intl Fantastic news, congratulations!

[Peter Grace, Ph.D. @DrPeterGrace]

We have two exciting postdoc opportunities in the lab to study mechanisms of chemotherapy-induced neuropathy, and autoimmune mechanisms of chronic pain https://t.co/hfscAbeQp4 https://t.co/9Tsh2g6t4O. DM me for more details!

[Dr. Annemieke Kavelaars @akavel]

In case you are ready for a break. This is the debut album of my brother in law. https://t.co/hEqo0izSVL

[Amanda Gorman @TheAmandaGorman]

Above all, I dare you to do good
So that the world might be great.

[Peter Grace, Ph.D. @DrPeterGrace]

Congrats @JixiangZhang1 this a great piece of work showing that an HDAC6 inhibitor only apparently reverses chemo pain. In fact, the inhibitor induces tonic ENK-delta opioid receptor signaling to suppress ongoing mechanical hypersensitivity.

[Jixiang Zhang @JixiangZhang1]

Very pleased to share our recent work: HDAC6 inhibition reverses cisplatin-induced mechanical hypersensitivity via tonic delta opioid receptor signaling. Thank you so much @akavel @CobiHeijnen @DrPeterGrace ! https://t.co/USZijBgKNW

[Dr. Annemieke Kavelaars @akavel]

@Eijkelkamp_N @MichielVlist Wonderful news, great to see the recognition of the work of @Eijkelkamp_N. Congrats!

[Alles Lab @AllesLab]

Another great paper examining neuroimmune mechanisms of CIPN from @akavel @GeoffroyLaumet and others. Interplay between CD8+ T-cell derived IL-13 and macrophage IL-10 is quite interesting #pain https://t.co/8qkOT29zEz

[JCI insight @JCI_insight]

CD8+ T cell–derived IL-13 increases macrophage IL-10 to resolve neuropathic pain: https://t.co/glbqKrEVpl
@akavel @MDAndersonNews
#Neuroscience

[Dr. Annemieke Kavelaars @akavel]

New paper in @JCI_insight: CD8 T cells and M2 macrophages collaborate to resolve pain. IL13 and IL10 are the players. https://t.co/sl9toe1g7E By Susmita K. Singh with @karenkrukowski @GeoffroyLaumet @CobiHeijnen @JenolynF_A @MDAndersonNews

[Dr. Annemieke Kavelaars @akavel]

CD8 T cells and M2 macrophages collaborate to promote resolution of pain. IL13 and IL10 are key. Susmita K. Singh, @GeoffroyLaumet @karenkrukowski @CobiHeijnen @JenolynF_A https://t.co/sl9toeiRwe

[Peter Grace, Ph.D. @DrPeterGrace]

The next workshop in our #Pain2022 series is THIS FRIDAY! Bin Feng, Nick Spencer, @OliviaEllerPhD @Vijay_Samineni Register here: https://t.co/O4fSwciMjt

[Advanced Portfolio @AdvPortfolio]

To prevent the long term cognitive side effects of some chemotherapies, scientists have developed a nasal therapy that delivers coated mitochondria to reverse neurotoxicity.

@JenolynF_A @CobiHeijnen @akavel @A_Seua

Learn more: https://t.co/CSp9g35KXS

[Jenolyn F. Alexander @JenolynF_A]

Targeting the meninges with nasal delivery of functionalized mitochondria resolves #chemotherapy induced cognitive deficits & signs of #pain ! Here’s how we did it @CobiHeijnen @akavel @A_Seua &others @MDAndersonNews @AdvSciNews

https://t.co/IYwgYYqVue

#neuroscience #nano

[Jixiang Zhang @JixiangZhang1]

Excited to share our latest research: macrophages, IL10, HDAC6 and Pain. Thanks for the greatest team and mentors. Dr Annemieke Kavelaars @akavel Dr Cobi Heijnen @CobiHeijnen and Vicky @jiacheng_ma . https://t.co/QtkaNVhXz9

[Niels Eijkelkamp @Eijkelkamp_N]

Pain resolving macrophages: Macrophages resolve inflammatory pain by donating their mitochondria to sensory neurons.
Team work with @MichielVlist @RaoofRamin @HLDMWillemen @LindeMeyaard. Proud! Such a fun, cool and inspiring collaboration.
https://t.co/n2KqJHx2Ce
A thread.1/n

[Dr. Annemieke Kavelaars @akavel]

Blake McAlpin currently defending his thesis on HDAC6 inhibition to treat chemobrain in mice

[Dr. Annemieke Kavelaars @akavel]

HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity https://t.co/6g8oWVwqtG #Theranostics long lasting changes in microglia after chemotherapy. @CobiHeijnen @MDAndersonNews

[Dr. Annemieke Kavelaars @akavel]

Thanks for a great talk and discussion!

[Rittner Lab. @HeikeRittner]

Thank you for the invitation! @akavel @CobiHeijnen Inspiring discussion! @ResolvePain