Alberto Perez-Alvarez

Research scientist, scrutinizing neurodegenerative diseases with light, electrophysiology and molecular biology.

[Alberto Perez-Alvarez @AlbertoNeuro]

Endoplasmic reticulum visiting spines is much more than a pretty movie, keeps synaptic strength from going through the roof! Out now👉https://t.co/FpSD6zumdx in @NatureComms! Ultimate privilege to study synapses with @OertnerLab. Grateful to @EMBO and #DFG

[Alberto Perez-Alvarez @AlbertoNeuro]

What is the endoplasmic reticulum (ER) doing in dendritic spines? It prevents runaway potentiation of excitatory synapses! Read about it in my last paper @OertnerLab.
Here 👇https://t.co/ZCOrB5GCMf Below: ER=green; cytosol=magenta (1/10)

[J. Simon Wiegert @SimWieg]

(Almost) all you need to know about the effects of anesthesia on the hippocampus. CA1 population dynamics, spine turnover, memory consolidation. Now updated with comparison to sleep, CA1 activity during 6h post anesthesia, layer-specific effects, and more: https://t.co/0eQglHhi3O

[Ricardo Gómez @ricardogyayo]

Last day of 2020 and my very first preprint after 18 years as a researcher.

Here you have: a story of two neuronal channels 👇👇👇

[Alberto Perez-Alvarez @AlbertoNeuro]

@Addgene @SFB_936 @BrenzyNM @OertnerLab @DIPCehu @SimWieg Yup, that's now me. Thanks

[Alberto Perez-Alvarez @AlbertoNeuro]

@JulirosaNeuro @OertnerLab @NatureComms Happy to read this, thanks!

[Alberto Perez-Alvarez @AlbertoNeuro]

@JulirosaNeuro @NatureComms @OertnerLab @EMBO Thank you, Juli!

[Alberto Perez-Alvarez @AlbertoNeuro]

Endoplasmic reticulum visiting spines is much more than a pretty movie, keeps synaptic strength from going through the roof! Out now👉https://t.co/FpSD6zumdx in @NatureComms! Ultimate privilege to study synapses with @OertnerLab. Grateful to @EMBO and #DFG

[Alberto Perez-Alvarez @AlbertoNeuro]

What is the endoplasmic reticulum (ER) doing in dendritic spines? It prevents runaway potentiation of excitatory synapses! Read about it in my last paper @OertnerLab.
Here 👇https://t.co/ZCOrB5GCMf Below: ER=green; cytosol=magenta (1/10)

[Alberto Perez-Alvarez @AlbertoNeuro]

@IgnacioArganda @NatureComms @OertnerLab @EMBO Thank you, Ignacio!

[Alberto Perez-Alvarez @AlbertoNeuro]

@JaestebanCBM @NatureComms Thank you, José Antonio!

[Paul J. Lamothe-Molina @neuronblaze]

Very excited to share our preprint on how time and space affect cFos ensembles in the dentate gyrus (DG), where we (@OertnerLab) combined #optogenetics and cFos-dependent tagging in the Morris water maze https://t.co/lV3zdnlB1F

[Alberto Perez-Alvarez @AlbertoNeuro]

@OKaneCahir This organelle pervades almost the entire neuron. EM studies showed that most spines in pyramidal neurons are devoid of ER. Our time-lapse analysis shows that this is just a matter of time and activity. ER will enter synapses as they go through periods of intense activity.

[Alberto Perez-Alvarez @AlbertoNeuro]

@YuriEliasR Excellent question. We don't know yet. Transient ER could be providing some sort of calcium signal triggered via CICR or mGluR-IP3, but also act as buffer. Last two scenarios are compatible with the lack of ER visits bringing about a potentiated state.

[Alberto Perez-Alvarez @AlbertoNeuro]

What is the endoplasmic reticulum (ER) doing in dendritic spines? It prevents runaway potentiation of excitatory synapses! Read about it in my last paper @OertnerLab.
Here 👇https://t.co/ZCOrB5GCMf Below: ER=green; cytosol=magenta (1/10)

[Alberto Perez-Alvarez @AlbertoNeuro]

@GertruPereaLab @OertnerLab Thanks Gertru!

[Alberto Perez-Alvarez @AlbertoNeuro]

@Ramon_Trullas Thanks. Have not tested it directly but, I believe the processive motor myosin V requires ATP for cargo transport upon actin binding.

[Alberto Perez-Alvarez @AlbertoNeuro]

We think that ER visits provide a brake mechanism at excitatory synapses during potentiation, thus keeping synaptic strength in check and allowing bidirectional synaptic plasticity. (10/10)

[Alberto Perez-Alvarez @AlbertoNeuro]

We wondered whether basal synaptic strength was altered in those neurons with impaired ER dynamics. Distribution of SEP-GluA2 showed enhanced spine enrichment of AMPA receptors. Two-photon glutamate uncaging on individual spines revealed higher AMPA and NMDA currents. (9/10)