Arshad Ali

Nephrologist FACP FASN | In love with Medicine | MKSAP-Reviewer Renal-physiology| EmoryNephrology | MorehouseMedicine | Love & hate Politics| Faith+Optimism🇺🇸

[AJKD @AJKDonline]

NEW on the #AJKDBlog:

@Maximal_Change interviews Manuel Laslandes and @c_massoumipour on response to rituximab as a maintenance therapy in adults with idiopathic nephrotic syndromes (INS):

https://t.co/Uzke8613fv

[AJKD @AJKDonline]

Association of Ertugliflozin on Kidney Outcomes in People After and Without an Interval Cardiovascular Event: Observations From the VERTIS CV Trial

https://t.co/yoLE3mDsFk (FREE)

[AJKD @AJKDonline]

Burden and Outcomes Associated With Heart Failure Hospitalizations Among Patients Treated With Dialysis

https://t.co/XFWJDgzFKu (FREE)

@loggyleila @BryanKestenbaum @NishaKidneyDoc @UWNephrology

[AJKD @AJKDonline]

Risks of Hypocalcemia and Other Bone Mineral Disorders for Denosumab Versus Zoledronate Across the Spectrum of Kidney Function: A Target Trial Emulation

https://t.co/T4zgAUgUUK

@jjcarrero1

[GlomCon @GlomCon]

An outstanding tribute to Helmut Rennke, a giant of renal pathology. @SethiRenalPath delivers the Helmut Rennke Endowed Lectureship on MPGN past, present, and future. A must-attend for all clinicians and pathologists.

#RenalPathology #MPGN #GlomConHawaii2026 #Nephrology #ScientificExcellence

[Sanjeev Sethi @SethiRenalPath]

This was a difficult but good teaching case.

Easy to call idiopathic MPGN but…

LM: Membranoproliferative Glomerulonephritis (MPGN) pattern

IF- dull minimal IgG IgM C3 kappa lambda

EM- massive deposits.

Pronase IF/IgG subclass all negative. At this point I had an idea-
FIBRONECTIN GLOMERULOPATHY

Did mass spectrometry. Confirmed the diagnosis=Large amounts of fibronectin.

55 yr old with proteinuria and declining renal function.

[Matthew Sparks, MD @Nephro_Sparks]

Avacopan retracted

https://t.co/YZsJ5O7ox3

[AJKD @AJKDonline]

Complement-Mediated Postpartum Atypical Hemolytic Uremic Syndrome With Collapsing Focal Segmental Glomerulosclerosis Associated With a Novel CFHR5 Copy Number Variant

https://t.co/jwTS4ARDBG (OPEN ACCESS)

@ComaiGiorgia @ariela_benigni

[AJKD @AJKDonline]

In A Few Words essay by Adam Krieger:

"Dialysis keeps people alive, but it also consumes them. We cannot dialyze a broken system, and we must not allow that system to dialyze away our vigilance."

What We Cannot Dialyze https://t.co/nPZx5V9J8u (FREE)

@TulaneMedicine

[AJKD @AJKDonline]

Kidney Transplant Outcomes in Coatomer Protein Complex Subunit Alpha (COPA) Syndrome: Report of Five Patients

https://t.co/ql7QsSAN79

[Roger Rodby @NephRodby]

Once again Last Month in Nephrology comes through. Great discussion about fluids in ICU sepsis (ARISE study 6/11 NEJM) . LESS may be more, clearly more in NOT more. Supports my statement that "volume is the new uremia". https://t.co/VuP84A5bgN

[Arshad Ali @aldorenin]

@silvishah @AST_info @coscia_lisa @docanjuyadav Congratulations 🎊

[Joel M. Topf, MD FACP @kidney_boy]

Advanced HF + hypotension creates a frustrating dilemma:

You need GDMT to improve outcomes.
You need blood pressure to give GDMT.
Does midodrine help with this or just add additional pharamcologic complications and noise?

This retrospective study <https://t.co/JyWNBAiE2V> found more GDMT initiation and uptitration with midodrine—but no improvement in survival and more hospitalizations 🤷🏻‍♂️

[Sanjeev Sethi @SethiRenalPath]

Overlap of C3GN and TMA (aHUS).
Both are complement-mediated diseases.

The study is the 1st to show overlap of C3GN-TMA findings in C3GN.
TMA findings are present on electron microscopy &amp; maybe missed.
The lesions are often C3GN-dominant or TMA-dominant.

https://t.co/oZXxywGMKm

[Sanjeev Sethi @SethiRenalPath]

Kidney biopsy: Great teaching case

Severe inflammation and necrosis with abscess formation.

Look carefully=you see cells with large nuclei in the mix of inflammatory cells.

IHC= Positive staining for ADENOVIRUS.

DX: Adenovirus-associated interstitial nephritis.

55-yr old with kidney &
heart transplant, fevers, rise in serum creatinine.

[Joel M. Topf, MD FACP @kidney_boy]

I love this study but it is easy to take the lessons too far. All of the 49,000 biopsies only happened after a nephrologist thought, "This doesn't look like DKD, we should get a biopsy"

[AJKD @AJKDonline]

Vaccinations to Prevent Infections in Adult Individuals With CKD and After Kidney transplantation: A Review

https://t.co/2hShv5JOLY #OpenAccess

[Joel M. Topf, MD FACP @kidney_boy]

https://t.co/ZYuj3Bvdzq

[AJKD @AJKDonline]

What is the approach to polyclonal hypergammaglobulinemia?

What is the differential diagnosis for a patient with tubulointerstitial nephritis and polyclonal hypergammaglobulinemia?

Quiz: https://t.co/2loGM0S52a (FREE)

[AJKD @AJKDonline]

KDOQI US Commentary on the KDIGO 2025 Clinical Practice Guideline for the Evaluation, Management and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

https://t.co/22G7lEXrB4 (FREE)

@ndahl48 @PauAugust @fouadchebib @mariehogan_md @KristenlNowak @terry_watnickmd