Aleepta Guha Ray

Postdoc, Weinstock Lab, UChicago, exploring the molecular basis of beneficial effects of weight loss in cardiovascular diseases

[Iannis Aifantis @iannisaifantis1]

Out today the last piece of work that Maria Guillamot did in our lab in a collaboration with @AWeinstock and @DrShrutiNaik (who lead the study) showing type I interferon (IFN)-mediated activation of hematopoietic stem/progenitor cells resulting in profound changes to systemic host responses...such studies could impact the way that we connect inflammation, autoimmunity to hematopoietic stem cell biology, differentiation and dysfunction...
https://t.co/2wqLpR8E7u

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[AdaWeinstock @AWeinstock]

Elated to share that the Weinstock lab just got its 1st R01!!

We are SO grateful to the hardworking NIH staff for tirelessly pushing to get those last NOAs out

[AdaWeinstock @AWeinstock]

Such a pleasure to see the final version of our paper finally published today!

[AdaWeinstock @AWeinstock]

We all know that weight loss in obesity is good- but why does it help? And why is weight regain afterward harmful? 🤔
Excited to announce our new paper is finally out in @JClinicalInvest! 🚀👇

https://t.co/DjhD8J669J

[Adipose Papers @adipose_papers]

Fabricating microfluidic co-cultures of immortalised cell lines uncovers robust design principles for the simultaneous formation of patterned, vascularised, and stem cell-derived adipose tissue. https://t.co/U9zWFGmmlo

[AdaWeinstock @AWeinstock]

We have an amazing phenotype related to #pregnancy
and #innate_immunity, but little expertise in maternal-fetus immunity. Anyone out there interested in a new
#collaboration, or can recommend someone?

[AdaWeinstock @AWeinstock]

I'm happy to present the 1st official PhD candidate of the Weinstock lab - @wmartinez_nav 🤗🤗🤗
He did an amazing job with his thesis proposal and presentation! Watch out for great discoveries 🧐🧐
#ProudPI 🥹🥹🥹

[AdaWeinstock @AWeinstock]

Weinstock lab rocking it at #ImmunometabGRC24 👏👏👏

It was great meeting all the incredible people of the immunometabolism community!

[David de Gea @D_DeGea]

Manchester is and always will be RED! 🔴🔴

[AdaWeinstock @AWeinstock]

So proud 🥹🥹 of the Weinstock lab members representing us at #AAI2024. Special congrats to @lourcatalina and @wmartinez_nav for getting awards!

Thank you for all that took the time to view our posters and give your input!

[Aleepta Guha Ray @aleepta]

@DonkTrading @TheCoinCity PC

[Ang Cui, Ph.D. @AngCuiPhD]

✨#ImmuneDictionary✨is out today in @Nature!

Paper https://t.co/XY47lyphjU
Software https://t.co/duoWWcBmTj

We created scRNA-seq dictionary of 17+ immune cell types responding to 86 cytokines in vivo, discovered the immune system is far more complex than previously known 1/

[BabaGol @BabaGol_]

What a performance! 🇮🇹Salernitana's fans honouring the legendary musical band, Pink Floyd 🤩🤩

[Aleepta Guha Ray @aleepta]

Only if I could fly 😅😅
Thanks boss! I really appreciate it.

[AdaWeinstock @AWeinstock]

Aleepta Guha Ray @aleepta, Postdoc
Superpower - Rescuer
Always there to help 🦸

#PostdocAppreciationWeek

[Kern Lipid Conference @KernLipid]

Thank you to all of our attendees, speakers, organizers and sponsors for making the 2023 Kern Lipid Conference unforgettable! @EbruErbayLab @AranyLab @DrMorganLevine

[Aleepta Guha Ray @aleepta]

Hi, if you are attending the #KernLipidConference, do drop by my poster (A-6) where I talk about the Immune cell dynamics during weight cycling in obese mice.

[Aleepta Guha Ray @aleepta]

Generalizing any experience for everyone paints a poor picture. I loved my PhD time courtesy of a great boss, good labmates & incredible friends. But I have seen too many around me stuck hopelessly & endlessly. We persevere as it's just a phase of life, we go on to better things!

[AdaWeinstock @AWeinstock]

The Weinstock lab belatedly celebrating a 1st birthday 🎂
Celebrations included:
A bunch of non-funded grant apps
Review article (published)
Manuscript (in revision)
Lots of amazing people😎

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu