Dr. Alejandro Soza 

Hepatólogo. Profesor Titular, Pontificia Universidad Católica de Chile.

[Martin Dib @dibmartin]

Happy weekend at BIDMC Transplant.

3 livers perfused simultaneously and transplanted within 24 hours.
Done safely.
Done deliberately.

Machine perfusion lets us choose the timing. We do not fight the clock anymore.

Grateful for an extraordinary team.

The future is now.

#TransplantSurgery #LiverTransplant #MachinePerfusion #TransMedics #BIDMC @BIDMCTransplant @BIDMC_CancerCtr @BIDMChealth @BIDMCSurgery @harvardmed @Harvard @Transmedics @ASTSChimera @AHPBA @IHPBA

[Dr. Alejandro Soza  @AlejandroSoza]

👇🏼

[EASLnews @EASLnews]

🗞️A major new guidance document on steatotic liver disease has just been published online, providing a global, multidisciplinary framework for screening and patient management across the entire disease spectrum.

With SLD affecting more than 1 in 3 adults worldwide, the document uses the patient trajectory as its anchor, providing practical recommendations on case finding, risk stratification, referral pathways and stage specific care, from early disease to advanced fibrosis and cirrhosis.

All recommendations are categorised as must have or nice to have, enabling adaptation across different healthcare systems and resource settings.

👉Read it now: https://t.co/G0ZpjKmgP0

@FrancqueSven

[Andrej Karpathy @karpathy]

It is hard to communicate how much programming has changed due to AI in the last 2 months: not gradually and over time in the "progress as usual" way, but specifically this last December. There are a number of asterisks but imo coding agents basically didn’t work before December and basically work since - the models have significantly higher quality, long-term coherence and tenacity and they can power through large and long tasks, well past enough that it is extremely disruptive to the default programming workflow.

Just to give an example, over the weekend I was building a local video analysis dashboard for the cameras of my home so I wrote: “Here is the local IP and username/password of my DGX Spark. Log in, set up ssh keys, set up vLLM, download and bench Qwen3-VL, set up a server endpoint to inference videos, a basic web ui dashboard, test everything, set it up with systemd, record memory notes for yourself and write up a markdown report for me”. The agent went off for ~30 minutes, ran into multiple issues, researched solutions online, resolved them one by one, wrote the code, tested it, debugged it, set up the services, and came back with the report and it was just done. I didn’t touch anything. All of this could easily have been a weekend project just 3 months ago but today it’s something you kick off and forget about for 30 minutes.

As a result, programming is becoming unrecognizable. You’re not typing computer code into an editor like the way things were since computers were invented, that era is over. You're spinning up AI agents, giving them tasks *in English* and managing and reviewing their work in parallel. The biggest prize is in figuring out how you can keep ascending the layers of abstraction to set up long-running orchestrator Claws with all of the right tools, memory and instructions that productively manage multiple parallel Code instances for you. The leverage achievable via top tier "agentic engineering" feels very high right now.

It’s not perfect, it needs high-level direction, judgement, taste, oversight, iteration and hints and ideas. It works a lot better in some scenarios than others (e.g. especially for tasks that are well-specified and where you can verify/test functionality). The key is to build intuition to decompose the task just right to hand off the parts that work and help out around the edges. But imo, this is nowhere near "business as usual" time in software.

[Dr. Alejandro Soza  @AlejandroSoza]

@theliverdoc Crazy, everybody knows you need to add quinoa to that mix in order to properly detox your liver!

[Dr. Alejandro Soza  @AlejandroSoza]

Felicitaciones al Dr. Arnoldo Riquelme, un na gran distinción completamente merecida. Un orgullo para nuestro Departamento
@FacMedicinaUC

https://t.co/R4aAZLqJEG

[Dr. Alejandro Soza  @AlejandroSoza]

@drkeithsiau Air bubble 🫧

[U.S. Senator Bill Cassidy, M.D. @SenBillCassidy]

As a liver doctor who has treated patients with hepatitis B for decades, this change to the vaccine schedule is a mistake. The hepatitis B vaccine is safe and effective. The birth dose is a recommendation, NOT a mandate.

Before the birth dose was recommended, 20,000 newborns a year were infected with hepatitis B. Now, it’s fewer than 20. Ending the recommendation for newborns makes it more likely the number of cases will begin to increase again. This makes America sicker.

Acting CDC Director O’Neill should not sign these new recommendations and instead retain the current, evidence-based approach.

[Dr. Alejandro Soza  @AlejandroSoza]

@yousafali_md @IhabFathiSulima Came to post the same thing.
AI, you’re getting better — but you’re still not quite ready for your residency.

[Dr. Alejandro Soza  @AlejandroSoza]

¡Inmensa alegría! 🎉 Merco Salud reconoció a nuestro Depto. de Gastroenterología @ucatolica como el Nº1 de Chile 🇨🇱.

Al basarse en la opinión de pares especialistas, este premio nos honra. Orgulloso de nuestro equipo 🙌 y de Clínica UC San Carlos @ucchristus por su logro.

[Dr. Alejandro Soza  @AlejandroSoza]

@DrAkhilX In addition to ampuloma, I’ve seen silver stools after a liver biopsy complicated with hemobilia, with blood clots obstructing the bile duct

[Rohit Loomba @DrLoomba]

Grateful to have such an amazing international organizing committee!!!

[Dr. Alejandro Soza  @AlejandroSoza]

🎓 Webinar gratuito
Te invito a participar en una interesante sesión sobre el manejo y seguimiento de la esteatosis hepática y la enfermedad hepática por alcohol.

🗓 Jueves 3 de julio | 🕖 19:00 hrs | 📍 YouTube

🔗 Inscripción gratuita: https://t.co/lYaxvVySwc

¡Te esperamos!

[Manuel Mendizabal @MMendizabalMD]

In 2024 WHO released new guidelines to simplify Hep B treatment

👉 We assessed treatment expansion by comparing country-specific vs WHO guidelines in South America

🚨 Result: a 10.4% increase in treatment eligibility, significantly higher among women

🔒https://t.co/SBPCau2SM4

[VCU Stravitz-Sanyal Institute for Liver Disease @VCU_Liver]

Join us May 28 for a presentation by @LuisAntonioDiaz, of
UC San Diego, on “MetALD: Bridging the Gap Between Metabolic Dysfunction and Alcohol-Associated Liver Disease.” Register at https://t.co/K4s6UQkE3G #livertwitter

[Dr. Alejandro Soza  @AlejandroSoza]

Cuando ChatGPT quiere llamarte por Zoom por fuera del chat... 🥶

[Dr. Alejandro Soza  @AlejandroSoza]

La eliminación de las hepatitis virales en Latinoamérica no será posible sin datos, cooperación y acción decidida. REVIRAL ofrece exactamente eso: articulación regional y un llamado urgente a los tomadores de decisión.

[Reviral @proyectoreviral]

¿Qué es REVIRAL?
"Más que un estudio o una iniciativa científica, REVIRAL es ya un espacio de cooperación y compromiso compartido con un objetivo ambicioso, pero profundamente necesario para nuestras regiones." @alehlatam @velardemd @DrJavierCrespo

[Juan Pablo (JP) Arab, MD  @juanpabloarab]

I am glad that this is on the news. We have known this for a number of years. Alcohol (even small amounts) increases the risk of liver disease, cardiovascular disease and cancer, among others.
Here our recent article:
https://t.co/y7r8890OHw
#ALDsig #ALDcure #LiverTwitter #LiverX

[Dr. Alejandro Soza  @AlejandroSoza]

@drkeithsiau Just for the record, vonoprazan is not a PPI

[Javier Crespo @DrJavierCrespo]

VI Life LATAM. Lima 24
Los fundamentos de la IA en medicina contados de forma breve y brillante por el profesor Mendizabal. @AEEHLiver @alehlatam @sepdigestiva

[Dr. Alejandro Soza  @AlejandroSoza]

@drkeithsiau @chandlerlikesit So elegant and polite letter…