Las nuevas guías de la American Society of Hematology (ASH, 2026) para Trombocitopenia Inmune. Algunos puntos y cambios:
🔴 Primera línea: ya no esteroide solo. Se sugiere Rituximab + esteroide o Agonistas del Receptor de Trombopoyetina (AR-TPO - como Eltrombopag)+ esteroide.
🔴 Segunda línea: Agonistas del Receptor de Trombopoyetina (AR-TPO). Orden: TPO-RA → rituximab → BTKi/MMF/SYKi → azatioprina.
🔴 Esplenectomía: diferir ≥1 año, vacunar ≥2 semanas antes, seguimiento anual.
🔴 Dosis: esteroide ≤6 semanas siempre; dexa 40 mg × 4 días (1–3 ciclos) o prednisona 0.5–2 mg/kg/día; rituximab 375 mg/m² × 4 semanas.
1. Can you identify the ECG signs marked in blue and green?
2. Which arrhythmia is associated with these findings?
📸 Courtesy of https://t.co/I2HI5J2HM9
ECG From Scratch: #1
What exactly is an #ECG?
An ECG is a time-voltage graph of the heart’s electrical activity.
In simple terms, it shows how cardiac electrical signals change from one moment to the next.
But where do these signals come from?
Think of the heart as an electrically timed pump:
⭕ Pacemaker cells act like tiny clocks, generating electrical impulses automatically.
⭕ Specialized conduction tissue acts like wiring, rapidly carrying these impulses.
⭕ Heart muscle cells respond to the electrical signal by contracting and pumping blood.
Normally, the heartbeat begins in the sinoatrial (SA) node, located in the right atrium.
The signal then travels:
SA node
⬇️
Atria
⬇️
AV node
⬇️
His bundle
⬇️
Right & left bundle branches
⬇️
Purkinje fibers
⬇️
Ventricles
Atrial activation produces atrial contraction. Ventricular activation produces ventricular contraction.
This connection between electrical activation and mechanical contraction is called electromechanical coupling.
One important point:
The surface ECG does not directly record every electrical structure in the heart. The signals from the SA and AV nodes are too small to be seen on a routine ECG.
Instead, the surface ECG primarily records the electrical activity generated by the large mass of atrial and ventricular muscle.
And that is why learning ECG interpretation starts with understanding how electrical activation spreads through the heart.
Next: Cardiac Automaticity & Conductivity
SONDA NASOGÁSTRICA 🚨🏥
✅️ Su uso se debe INDIVIDUALIZAR 🤕
✅️ Principal indicación - OBSTRUCCIÓN DE INTESTINO DELGADO 🚫
❎️ NO usar de rutina en cirugía gastrointestinal 🔪
✅️ Reevaluar DIARIO su permanencia ⚠️
JAMA. 2026
Dscarga ⬇️⬇️⬇️
https://t.co/zOZZjqDoHQ
Treatment of Essential Hypertension (Adults)
Step 1
◻️ Age <55 years: Start an ACE inhibitor (ACEi) or ARB (ARB if ACEi is not tolerated).
◻️ Age ≥55 years or Black African/Black Caribbean ethnicity: Start a calcium channel blocker (CCB).
Step 2
◼️ACEi/ARB + CCB
◼️ If a CCB is not tolerated, use a thiazide-like diuretic instead.
Step 3
◻️ ACEi/ARB + CCB + thiazide-like diuretic
Step 4 (Resistant Hypertension)
◻️ If serum potassium is ≤4.5 mmol/L: Add low-dose spironolactone.
◻️ If serum potassium is >4.5 mmol/L: Consider an alpha-blocker or beta-blocker, or seek specialist advice.
Key point: Use either an ACE inhibitor or an ARB, never both together.
Reference: NICE Guideline NG136: Hypertension in adults: diagnosis and management (updated February 2026).
Una persona murió en la #Huamantlada 2026 y nueve resultaron heridas durante el tradicional encierro de toros que recorre las principales calles de #Huamantla. 🐃