Paul smith

Got Multiple sclerosis and loves life.

let's help those in need of help and be kind.. always be kind to people.

[Paul smith @alize_paul]

@DrewIsSharing @Zmoney448 @wizard_trees @MaisonOCA @thetenco_ The ziki skywalker come close?

[Chris Smith @renewablesmiffy]

@TiceRichard Weapons grade nonsense. If you genuinely think this you should never be an energy spokesperson for any politics party and if you don’t your lying with motive

We had 65% spare gas generation capacity available today with reactors down for maintenance

There was no shortage

[Paul smith @alize_paul]

@ddo They look class

[Paul smith @alize_paul]

@ddo Could I use a glass tip, 11mm I one of these?

[Paul smith @alize_paul]

@chiamakaafc Coventry

[Paul smith @alize_paul]

@waitmaya 31

[Paul smith @alize_paul]

@Kushonmybrain @BuddysBodegaCA @Kushonmybrain was this decent ?

[Paul smith @alize_paul]

@DrewIsSharing Tbh im influenced by your review

[Paul smith @alize_paul]

@DrewIsSharing I can only find it at the 180 mark. I would pay but for a payday treat. I'd hope itd be like the champagne of a smoke

[Paul smith @alize_paul]

@Kushonmybrain @BuddysBodegaCA It looks fire, love a skywalker

[Emma @WhatTheForkAVFC]

I do believe i have happened upon my favourite England edit of the day.

I’m in the mood. 🏴󠁧󠁢󠁥󠁮󠁧󠁿

[Paul smith @alize_paul]

@Sakaextra2 Owen Hargreaves

[Massimo @Rainmaker1973]

Scientists have resurrected "extinct" enzymes from ancient cannabis ancestors that lived millions of years ago, opening the door to more powerful anti-inflammatory treatments and dramatically cheaper drug production.

A team at Wageningen University in the Netherlands used ancestral sequence reconstruction—a cutting-edge technique that reconstructs the genetic history of a species—to revive long-lost enzymes from the prehistoric relatives of the cannabis plant.

Unlike modern cannabis, which relies on highly specialized enzymes to produce specific cannabinoids such as THC or CBD, these ancient enzymes were remarkably versatile ("promiscuous"). They could generate a wide range of cannabinoids at once, revealing how early cannabis plants likely evolved sophisticated chemical defenses against ancient pests and diseases.

The breakthrough has major implications for medicine and biotechnology. One resurrected enzyme proved exceptionally efficient at producing CBC (cannabichromene)—a cannabinoid prized for its potent anti-inflammatory effects but scarce in today's strains. By reintroducing these ancient genes into modern plants or using them in microbial fermentation systems, researchers aim to develop far more efficient, scalable, and cost-effective ways to produce therapeutic cannabinoids.

This work not only sheds new light on the evolutionary origins of cannabinoids but also provides a powerful new toolkit for engineering the next generation of affordable, high-potency plant-derived medicines.

[Villard C, Baser I, van de Peppel AC, Cankar K, Schranz ME, van Velzen R., "Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases", Plant Biotechnology Journal. 2025 Dec 26. Advance online publication. DOI: 10.1111/pbi.70475]

[Paul smith @alize_paul]

@Kushonmybrain Smoking 🔥

[Paul smith @alize_paul]

@dabura365 That looks proper smart

[Paul smith @alize_paul]

@Kushonmybrain Same tbh

[Paul smith @alize_paul]

@BestBitsTT You getting these In bro?

Don't think you could find anyone

[KushOnMyBrain @Kushonmybrain]

MARY JANE BERLIN.. someone told me there’s a limited batch of KOMB-cannons at the @Zmoney448 booth.. F2, Hall 22 👀🔥

[Paul smith @alize_paul]

@atrupar Has he actually posted this?

[Paul smith @alize_paul]

@bananapearlsss @Zikigai_Gardens An exquisite roll