Alvindhp

[Alvindhp @alvindhp]

@stephenwitt Horrible “journalist”

[Frieda Li @FriedaLi3]

A Chinese story I can't stop thinking about.

Cai Lei was a vice president at https://t.co/gXYlXDsQtZ — a workaholic who helped take the company public. In 2019, he was diagnosed with ALS and given two to five years to live.

He didn't retreat. He called it his "final startup."

He went on to build the world's largest grassroots ALS research platform: a patient database of over 20,000 people, hundreds of scientists working together, nearly 300 drug pathways pursued, more than 30 now in clinical trials. His wife Duan Rui left her partnership at an accounting firm to fund the research through livestreaming — over 100 million yuan invested, and she has never taken a cent in salary.

This year, RAG-17, a homegrown drug he helped advance, completed Phase II trials. The findings, published in Nature Medicine: disease-causing proteins in patients' cerebrospinal fluid fell by nearly 60%, and the disease's progression was held back.

Here's the part that stays with me. Cai Lei has sporadic ALS — the drug targets genetic mutations he doesn't have. The medicine he fought so hard for may never save him.

His answer: I'm not trying to save myself. I'm trying to save others. Even if I fall in the darkness before dawn, I'll make sure the path is ready — so those who come after me can stand on my shoulders and step into the sunlight.

Today, only his eyes can move. With an eye-tracking device he types around 60 words a minute and works ten-hour days.

One detail worth noting: after his diagnosis, https://t.co/gXYlXDsQtZ introduced a policy to cover the education and living expenses of any employee’s children if the employee suffers a serious tragedy while in service, continuing until the children turn 22. That policy exists because of Cai.

Video: [credit @长歌人物志] | English subtitles auto-generated by AI

[Longwood（大根） @Longwood7777777]

这做的短剧真绝了

[Massimo @Rainmaker1973]

Swans might have one of the most underrated landing techniques in the animal kingdom.

[王陽 @wyang6636]

20年以上前のNIKEの中国CM。
めっちゃローカライズだし、めっちゃ面白い。

[Massimo @Rainmaker1973]

This man trusted his life to physics. He was ejected at 80 km/h from a truck that was traveling at 80 km/h.

[Massimo @Rainmaker1973]

A wonderful tribute to the victims of 9/11 by Sky Element Drones, 2,977 Lights over New York Harbor. One light for every life lost.

[Alvindhp @alvindhp]

@UTDMael Zanetti

[Massimo @Rainmaker1973]

This is what the lion dance looks like without the costumes

[Anish Moonka @anishmoonka]

June 1983. A 28-year-old Steve Jobs walks into a design conference in Aspen, Colorado. He asks the room who owns a personal computer. Nobody raises their hand. He says “Uh-oh.”

Then he spends the next 55 minutes describing the next four decades of technology.

Jobs told the audience Apple’s strategy was to “put an incredibly great computer in a book that you can carry around with you, that you can learn how to use in 20 minutes… with a radio link in it so you don’t have to hook up to anything.” That’s an iPhone. In 1983. The Mac hadn’t even shipped yet.

He described an MIT project that sent a camera truck down every street in Aspen, photographed every intersection, and built a virtual walkthrough on a computer screen. Google Street View launched 24 years later. He said office networking was about 5 years away and home networking 10 to 15 years out. The web went mainstream in the mid-90s, about 12 years later. Dead on.

He described software being sent electronically over phone lines, with free previews and credit card payment. That’s the App Store, 25 years before it launched. He even compared it to the music industry and said software needed “the equivalent of a radio station” for free sampling. Apple built the iTunes Music Store 20 years later.

The AI prediction is the one that hits different now. Near the end, Jobs talked about machines that could capture a person’s “underlying spirit” or “way of looking at the world,” so that after they died, you could ask the machine questions and maybe get answers. He said 50 to 100 years. ChatGPT arrived in about 40.

The weird part is this speech was lost for nearly 30 years. The full hour-long recording only surfaced in 2012 when a blogger got a cassette tape from someone who attended the original conference. The Steve Jobs Archive didn’t release actual video footage until July 2024.

His timelines were consistently too fast. He wanted the “computer in a book” within the 1980s. Apple’s first attempt was the Macintosh Portable in 1989, which weighed 16 pounds and cost $6,500. The iPad arrived in 2010, 27 years late. He guessed voice recognition was about a decade away. Siri launched in 2011, nearly 30 years later. The vision was right every time. The clock was wrong every time.

Apple was doing about $1 billion a year in revenue when Jobs gave this talk, with under 5,000 employees. Today it’s worth $3.7 trillion.

[The Figen @TheFigen_]

This child had 25 secs to make 4 baskets for $10,000.00.

[Nature & Animals🌴 @naturelife_ok]

When the TV Turns Off but the Dance Party Isn’t Over 🐶🤣

[Vala Afshar @ValaAfshar]

Fate whispers to the warrior, 'You can not withstand the storm.'

The warrior whispers back, 'I am the storm.'

[Sergey Karayev @sergeykarayev]

This robot solving a rubiks cube in 0.103 seconds is a little preview of what "AGI" really means

[Aksara @rajameru]

Physics are amazing

[Fastbreak Hoops @FastbreakHoops5]

Kobe’s final time at the Staples Center in 2019 😢

[Li Jingjing 李菁菁 @Jingjing_Li]

This is a really dope cover of Michael Jackson's Black or White 😂

... with strong Chinese characteristics!

[Historic Vids @historyinmemes]

In 1985 an astronaut noticed this physical behavior of a handle, that turned out to be the proof of a theorem: the tennis racket theorem (also dubbed the Dzhanibekov effect).

[Kevin W. @Brink_Thinker]

She hacks the game with her mind!

[DD Geopolitics @DD_Geopolitics]

🇺🇸 MTG just took full ownership on CNN and it’s one of the most unexpected moments of the year.

When asked why she only denounced Trump’s rhetoric after it was directed at her, she didn’t deflect. She owned it:

“That’s fair criticism… and I would like to say humbly, I’m sorry for taking part in the toxic politics. It’s very bad for our country.”

She went further, nvoking Charlie Kirk’s assassination as a wake-up call and pledging to “put down the knives in politics.” Then came the biggest moment:

“I think America needs to come together and end all the toxic, dangerous rhetoric and divide and I’m leading the way with my own example. I hope President Trump can do the same.”

Marjorie Taylor Greene just became the first MAGA figure to break the cycle of escalation and publicly ask Trump to change.