Amandeep Singh

Aspiring Medical Writer ✍️ Join me on my writing journey! Sharing neuroscience discoveries every week. PhD @astonuniversity 🧠

[Amandeep Singh @amansingh_96]

Overall, this paper highlighted that claudin-11 is significantly downregulated at the BBB and BSCB of an MS patient, and that an increase in CNS barrier permeability is observed in monolayers of endothelial cells (and epithelial cells - data not shown). (7/7)

[Amandeep Singh @amansingh_96]

What role does claudin-11 have on blood-brain barrier disruption in Multiple Sclerosis?

This was one of the questions posed by a group of Japanese scientists. https://t.co/oFkPNNh5Xx

Here's what they found: 🧵/7

[Amandeep Singh @amansingh_96]

Downregulation of claudin-11 in a MS patient's BBB and blood-spinal cord barrier (BSCB):

A 64-year old MS patient's brain and spinal cord was used to explore claudin-11 expression. In three BBB and BSCB capillaries of the MS patient, there was a significant reduction of claudin-11 expression. (6/7)

[Amandeep Singh @amansingh_96]

What’s your opinion on authors of research articles stating they’ve noticed a difference between two conditions, but the difference was not statistically significant?

I’ve been told to not include such statements. I understand that sometimes statistical differences do not always mean clinical significance. And that the opposite could possibly be true as well.

It just triggers me for some reason when I see it…😭

[Amandeep Singh @amansingh_96]

@ScholarshipfPhd Maturing

[Amandeep Singh @amansingh_96]

The two types of stroke:

[Top Science @isciverse]

Understanding stroke

[Amandeep Singh @amansingh_96]

(4/4) Check out this systematic review for more information regarding Fexofenadine and the brain.

https://t.co/SW4G3ElFo1

[Amandeep Singh @amansingh_96]

(3/4) Fexofenadine's higher selectivity blocks H1 receptors, preventing airway restriction and vasodilation caused by allergies. Its higher affinity for P-glycoprotein ensures more drug binds to H1 receptors throughout the body. This means Fexofenadine is more effective.

[Amandeep Singh @amansingh_96]

(2/4) Fexofenadine does not cross the blood-brain barrier due to the hydrophilic groups in its structure. Therefore, it cannot enter the brain and exert the sedative effects that 1st generation antihistamines do - keeping the user alert, in control, and safe.

[Amandeep Singh @amansingh_96]

You are less likely to fall asleep at the wheel when taking the antihistamine, Fexofenadine, compared to Brompheniramine. Why?

The answer lies in the blood-brain barrier and the structural properties of 2nd generation antihistamines. 🧵/4

[Leigh A. Frame 🍎🥕🍋🥦🍇 @PhD_Leigh]

🧠 Bacteria in the Brain?
For years, scientists believed bacteria couldn’t survive in the brain. But new research suggests otherwise, challenging our understanding of brain health and its microbiome.

⚠️ A word of caution: Stay skeptical! Similar findings in the past were debunked due to sample contamination.
💡 Could this discovery reshape how we view brain health, or is it another case of contamination?

🔗 Read the full article here: https://t.co/fD6q67wfIk

#Neuroscience #Microbiome #Research #BrainHealth #Science #Health #ScientificDiscovery

[Amandeep Singh @amansingh_96]

@DrAwanHealth Yooks lummy!

[Amandeep Singh @amansingh_96]

@DrAwanHealth I planned my month before it even started.

Now what. Run a marathon you’d say 🤔

[Amandeep Singh @amansingh_96]

Scientists, what do you get up to during long incubation periods?

[Amandeep Singh @amansingh_96]

3 hours in, of a 4 hour incubation period…
There’s only so many coffees one can drink 😫