Chromatin labeling and imaging

MPI for Multidisciplinary Sciences
Fluorescent #probes for live-cell #nanoscopy: #STED, #MINFLUX and #confocal. We do the job, all of you judge if it is useful!

[Chromatin labeling and imaging @AndImaging]

New preprint !

OptiFoot allows imaging of protein–nucleic acid interactions and places them into sequence context using Optical Genome Mapping, bridging super-resolution microscopy with single-molecule genomic analysis.

#Genomics #Chromatin #Microscopy

https://t.co/LOtKH8dnkK

[Nature Chemical Biology @nchembio]

Illuminating microtubule architecture – Check out the associated News and Views by Rūta Gerasimaitė Gražvydas Lukinavičius

https://t.co/U5TWjQMkPi

[Nature Chemical Biology @nchembio]

CenSpark is a dual-ligand fluorescent probe simultaneously binding inner and outer microtubule sites – a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species

https://t.co/ncTWrxELeY

[Chromatin labeling and imaging @AndImaging]

News & Views in @nchembio : CenSpark offers a new perspective on microtubule organization—moving beyond tubulin to capture higher-order structure in live cells.

#AcademicPublishing #ResearchImpact #imaging

https://t.co/DViqatrqs7

[Chromatin labeling and imaging @AndImaging]

Just published in @JACS_Au ! https://t.co/mkC8B5p0iE

We show that the remarkable stability of proline-derived cofactors enabling efficient DNA labeling using methyltransferases—even under harsh conditions.

Thanks to the contributors: @J_Bucevicius and @GerasRuta !

[Chromatin labeling and imaging @AndImaging]

New Year, New Microscope! We just got upgraded to Abberior MIRAVA POLYSCOPE — confocal → MATRIX → STED. First test looks good, large area and nice STED images using our probes.

@Abberior @StefanHellLabs

#microscopy #livecell #fluorescence #bioimaging

[Chromatin labeling and imaging @AndImaging]

New preprint! The remarkable stability of proline-derived cofactors opens efficient DNA labeling possibility using methyltransferases even at harsh conditions.

https://t.co/gEaSHXR6ER

Congratulations to @GerasRuta and @J_Bucevicius .

#Biochemistry #DNA #Fluorescence

[Chromatin labeling and imaging @AndImaging]

Wish all of You Merry Christmas and a Happy New Year!!!

Enjoy AI-generated card for Chromatin labeling and imaging @AndImaging

[Chromatin labeling and imaging @AndImaging]

New preprint! We systematically evaluate red-shifted rhodamine-based DNA probes for in vivo chromatin imaging. Congratulations to Kamila and Shalini (@ShaliniPradha19) et al.
Job done at @mpi_nat . Read more if you want to know which isomer is the best: https://t.co/LDXitsZZGS .

[Chromatin labeling and imaging @AndImaging]

We developed 6SiR-C3-NextA, a bright far-red, cell-permeable probe, enabling selective imaging of endogenous HDAC6 in living cells.
Congratulations to Van-Thang Nguyen et al. (@Eyeshield_VN_21)! Developed at @mpi_nat and published on BioRxiv https://t.co/x0SDgLj1Sh .

[Chromatin labeling and imaging @AndImaging]

Celebrating 2nd PhD student of the group! 🎓 Van-Thang Nguyen (@Eyeshield_VN_21) from the Chromatin Labeling & Imaging group successfully defended his thesis through the @IMPRS_GS program at @mpi_nat. A smooth and impressive defense — and his paper is coming soon… 👀📄

[Chromatin labeling and imaging @AndImaging]

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes.

The proof-of-concept paper is out in @NatureComms : https://t.co/LeXJy9bjUf

Great job done by @MarieAuvray4 at @mpi_nat !

[Chromatin labeling and imaging @AndImaging]

Happy DNA day!!! 😀
#DNA #Chromatin #research

[Chromatin labeling and imaging @AndImaging]

The updated Team of @AndImaging .

We will keep you posted with our newest developments. Follow us:

@J_Bucevicius
@GerasRuta
@GeorgijKostiuk
@Eyeshield_VN_21
@D_Bubnyte
@kenji_tori38197

[Chromatin labeling and imaging @AndImaging]

We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes.

The proof-of-concept paper is on BioRxiv: https://t.co/Qtw95GVh4v .

Great job done by @MarieAuvray4 at @mpi_nat !

Enjoy reading!

[Chromatin labeling and imaging @AndImaging]

Wish all of You Merry Christmas and a Happy New Year!!!

Enjoy DALL-E AI-generated card for Chromatin labeling and imaging @AndImaging

[Chromatin labeling and imaging @AndImaging]

Finally, we have the 1st PhD student Shalini Pradhan @ShaliniPradha19 from Chromatin labeling and imaging group from @IMPRS_GS program at @mpi_nat . It was challenging to make the full program in a single day, but we succeed.

[Schuh Lab @SchuhLab]

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired?

Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥

https://t.co/hd8iT1TKnJ (1/13)

[Skirmantas Kriaucionis @sk_kriaucionis]

Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. https://t.co/V42N3MDEGG

[MPI for Multidisciplinary Sciences @mpi_nat]

A team led by Steffen Sahl & @Stefan_W_Hell @mpi_nat and @mpi_mr_hd has succeeded in measuring distances within biomolecules using the #MINFLUX microscopy method, down to 1 nanometer and with Ångström precision. Read more in our press release:
https://t.co/NuAdZkXf6v