MPI for Multidisciplinary Sciences
Fluorescent #probes for live-cell #nanoscopy: #STED, #MINFLUX and #confocal. We do the job, all of you judge if it is useful!
New preprint !
OptiFoot allows imaging of protein–nucleic acid interactions and places them into sequence context using Optical Genome Mapping, bridging super-resolution microscopy with single-molecule genomic analysis.
#Genomics#Chromatin#Microscopy
https://t.co/LOtKH8dnkK
CenSpark is a dual-ligand fluorescent probe simultaneously binding inner and outer microtubule sites – a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species
https://t.co/ncTWrxELeY
News & Views in @nchembio : CenSpark offers a new perspective on microtubule organization—moving beyond tubulin to capture higher-order structure in live cells.
#AcademicPublishing#ResearchImpact#imaging
https://t.co/DViqatrqs7
Just published in @JACS_Au ! https://t.co/mkC8B5p0iE
We show that the remarkable stability of proline-derived cofactors enabling efficient DNA labeling using methyltransferases—even under harsh conditions.
Thanks to the contributors: @J_Bucevicius and @GerasRuta !
New preprint! The remarkable stability of proline-derived cofactors opens efficient DNA labeling possibility using methyltransferases even at harsh conditions.
https://t.co/gEaSHXR6ER
Congratulations to @GerasRuta and @J_Bucevicius .
#Biochemistry#DNA#Fluorescence
New preprint! We systematically evaluate red-shifted rhodamine-based DNA probes for in vivo chromatin imaging. Congratulations to Kamila and Shalini (@ShaliniPradha19) et al.
Job done at @mpi_nat . Read more if you want to know which isomer is the best: https://t.co/LDXitsZZGS .
We developed 6SiR-C3-NextA, a bright far-red, cell-permeable probe, enabling selective imaging of endogenous HDAC6 in living cells.
Congratulations to Van-Thang Nguyen et al. (@Eyeshield_VN_21)! Developed at @mpi_nat and published on BioRxiv https://t.co/x0SDgLj1Sh .
Celebrating 2nd PhD student of the group! 🎓 Van-Thang Nguyen (@Eyeshield_VN_21) from the Chromatin Labeling & Imaging group successfully defended his thesis through the @IMPRS_GS program at @mpi_nat. A smooth and impressive defense — and his paper is coming soon… 👀📄
We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes.
The proof-of-concept paper is out in @NatureComms : https://t.co/LeXJy9bjUf
Great job done by @MarieAuvray4 at @mpi_nat !
We have introduced a new biocompatible sulfonium-based building block for generation of non-cytotoxic covalent fluorescent probes.
The proof-of-concept paper is on BioRxiv: https://t.co/Qtw95GVh4v .
Great job done by @MarieAuvray4 at @mpi_nat !
Enjoy reading!
Finally, we have the 1st PhD student Shalini Pradhan @ShaliniPradha19 from Chromatin labeling and imaging group from @IMPRS_GS program at @mpi_nat . It was challenging to make the full program in a single day, but we succeed.
Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired?
Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥
https://t.co/hd8iT1TKnJ (1/13)
Cost of having DNA methylation: DNA replication by DNA polymerase epsilon is a source of C to T mutations in CpGs, especially methylated ones. This expands our understanding of one of the most widespread endogenous mutational mechanisms. https://t.co/V42N3MDEGG
A team led by Steffen Sahl & @Stefan_W_Hell@mpi_nat and @mpi_mr_hd has succeeded in measuring distances within biomolecules using the #MINFLUX microscopy method, down to 1 nanometer and with Ångström precision. Read more in our press release:
https://t.co/NuAdZkXf6v