Andrew Chadeayne

CEO at CaaMTech

[Grant Glatfelter @gcglatfelter]

New pub out now in @ACSChemNeurosci comparing 5-HT1A & 5-HT2A activities of #5MeODMT analogs

#psychedelics

https://t.co/3s1NVZb4uI

[CaaMTech @CaaMTechInc]

CaaMTech’s new clinical trial design solves the emergent functional unblinding problems plaguing #psychedelic medicine developers https://t.co/bdAuyIGgJI

[Andrew Chadeayne @AndrewChadeayne]

@dirtwire Yeah!! Let’s go!

[Andrew Chadeayne @AndrewChadeayne]

@FirstAvenue What a great show!!

[Dirtwire @dirtwire]

Listen here: https://t.co/lvQ5iRsJlF

[Andrew Chadeayne @AndrewChadeayne]

@FatherMcKennaa Bluing means degradation by (1) dephosphorylation of psilocybin to psilocin and then (2) oxidation and coupling to form a dimeric (blue) product. See link. We now also know that the dephosphorylation must be enzymatic. Still a nice color though. https://t.co/MwqPqAC9lF.

[Charles Nichols @lab_nichols]

Get your manuscript submitted by the end of this week in order for potentially inclusion in our inaugural issue! #psychedelic #5HT2A #psilocybin https://t.co/4yUDURKsec

[Andrew Chadeayne @AndrewChadeayne]

@BrandtAsher @gcglatfelter I think you've done a good job setting the stage. There's the fundamental O-chem acidic hydrolysis of esters; and for 4-AcO-DMT the kinetics of that reaction are far too slow to explain the in vivo biological results. Why? Enzymes catalyze the reaction.

[Andrew Chadeayne @AndrewChadeayne]

@BrandtAsher @gcglatfelter I'm unclear what that has to do with your drawing.

[Andrew Chadeayne @AndrewChadeayne]

@BrandtAsher @AmirKhajavinia Do you mean deprotonation of the DOUBLY protonated acetic acid (like you've drawn)? Either way, how is that compound co-existing with the freebase amine? Also, don't you think that neutral acetic acid might react with that amine to make an acetate salt?

[Andrew Chadeayne @AndrewChadeayne]

@FrankJa12049741 Yes.

[CaaMTech @CaaMTechInc]

Psilacetin is More Potent than Psilocybin:
@CaaMTechInc, @NIDAnews, @usonainstitute, @ResearchUGent, @UMassD and @UWyonews researchers directly compared #psilocybin with understudied #magicmushroom molecules, and synthetic analogs such as psilacetin
https://t.co/BeKsidlYbB

[Grant Glatfelter @gcglatfelter]

New article out now regarding the pharmacology of #psilocybin analogues including other compounds found in psilocybin-containing mushrooms, their active metabolites, and 4-acetoxy derivatives.

https://t.co/TvYHm1Nrgy

#pharmacology #psychedelics #aeruginascin #baeocystin

[CaaMTech @CaaMTechInc]

Thank you @FastCompany for highlighting our important work in #psychedelics as a part of "15 tech startups to watch in 2022." 👨‍🔬🧪

Read @thesullivan's piece here: https://t.co/GPFA1D16nG

[Taylor Sterling @FatherMcKennaa]

I'd love to see a study on psychedelics treating long COVID, there are some insane case reports

[NXTpsychedelics @NXTpsychedelics]

CaaMTech Creates Two New Prodrugs of 4-HO-DiPT

CaaMTech scientists, in collaboration with the Manke Lab at UMass Dartmouth, recently reported their synthesis and structural characterization of two novel

#psychedelics #StocksToBuy #trading

https://t.co/U5T1QqdrMF

[Andrew Chadeayne @AndrewChadeayne]

@TekGordo @CaaMTechInc @marilyn_naeem @BarbBauerCT @UMassD Wow- Thanks for your interest! We just got a new paper accepted (which we've been working on for 2.5 years) that has some new norpsilocin data. It should be out this month. We have a bunch of others that will follow.

[Nick Jikomes @trikomes]

One of the most popular podcast episodes I've done this year was w/ @AndrewChadeayne, CEO of biotech startup @CaaMTechInc.

We did a fairly deep dive into the chemistry & pharmacology of tryptamine #psychedelics, e.g. psilocybin, DMT.

Listen here: https://t.co/GyLOglZTsz

[CaaMTech @CaaMTechInc]

New paper by @CaaMTechInc @marilyn_naeem @BarbBauerCT @UMassD @AndrewChadeayne! 4-HO-DiPT has been proposed as a more clinically-optimized alternative to #psilocybin

#psychedelic #science #chemistry #crystallography

https://t.co/VnSbbbM4Wb