@FatherMcKennaa Bluing means degradation by (1) dephosphorylation of psilocybin to psilocin and then (2) oxidation and coupling to form a dimeric (blue) product. See link. We now also know that the dephosphorylation must be enzymatic. Still a nice color though. https://t.co/MwqPqAC9lF.
Get your manuscript submitted by the end of this week in order for potentially inclusion in our inaugural issue! #psychedelic#5HT2A#psilocybin https://t.co/4yUDURKsec
@BrandtAsher@gcglatfelter I think you've done a good job setting the stage. There's the fundamental O-chem acidic hydrolysis of esters; and for 4-AcO-DMT the kinetics of that reaction are far too slow to explain the in vivo biological results. Why? Enzymes catalyze the reaction.
@BrandtAsher@AmirKhajavinia Do you mean deprotonation of the DOUBLY protonated acetic acid (like you've drawn)? Either way, how is that compound co-existing with the freebase amine? Also, don't you think that neutral acetic acid might react with that amine to make an acetate salt?
New article out now regarding the pharmacology of #psilocybin analogues including other compounds found in psilocybin-containing mushrooms, their active metabolites, and 4-acetoxy derivatives.
https://t.co/TvYHm1Nrgy
#pharmacology#psychedelics#aeruginascin#baeocystin
Thank you @FastCompany for highlighting our important work in #psychedelics as a part of "15 tech startups to watch in 2022." 👨🔬🧪
Read @thesullivan's piece here: https://t.co/GPFA1D16nG
CaaMTech Creates Two New Prodrugs of 4-HO-DiPT
CaaMTech scientists, in collaboration with the Manke Lab at UMass Dartmouth, recently reported their synthesis and structural characterization of two novel
#psychedelics#StocksToBuy#trading
https://t.co/U5T1QqdrMF
@TekGordo@CaaMTechInc@marilyn_naeem@BarbBauerCT@UMassD Wow- Thanks for your interest! We just got a new paper accepted (which we've been working on for 2.5 years) that has some new norpsilocin data. It should be out this month. We have a bunch of others that will follow.
One of the most popular podcast episodes I've done this year was w/ @AndrewChadeayne, CEO of biotech startup @CaaMTechInc.
We did a fairly deep dive into the chemistry & pharmacology of tryptamine #psychedelics, e.g. psilocybin, DMT.
Listen here: https://t.co/GyLOglZTsz