brom

Founding partner at @XEIA_VP

Building Human 3

[brom @therealbrom]

Excited to announce @focalpointlp's "Human 3" thesis: the era of exponential human flourishing.

While modern medicine (Human 2) benefited society in incalculable ways, it ultimately fell short of its promise because the available tools forced it to operate at an incremental pace with long feedback loops.

Today, exponential technologies like AI - which can parse through terabytes of scientific literature and data in seconds - and brain-computer-interfaces, biosensors and CRISPR - which enable real-time, read-write access to our biology - promise to rapidly accelerate the scientific method flywheel and lead to an exponential explosion in health, wellness and performance.

Human 3 will elevate every area of health and wellbeing, but will have the biggest impact in areas where modern medicine has made the least progress: the mental health crisis, neurodegeneration, chronic disease and aging. These are the “focal points” of our investment strategy.

Human 3 is not a “sector” - our companies combine life sciences, AI, hardware, software, deep tech & health tech in novel ways that often defy conventional categorization. Human 3 is a philosophy of vitality. It is a knowing that the “user experience” of the human body and mind is long overdue for an upgrade. It is the willingness to build and invest in that future. This is Human 3.

This movement marks the third great epoch of human health:

- Human 1 was defined by medieval practices like bloodletting and humorism - medicine before evidence.

- Human 2 was the era of “modern” medicine, which began in the 1850s when Louis Pasteur popularized the germ theory of disease and the scientific method became the gold standard. Human 2 was constrained by both incremental tools and artificial boundaries between disciplines.

- Human 3 builds on Human 2’s legacy of scientific rigour, but is accelerated by exponential technologies, transdisciplinary collaborations, and driven by a belief that we can do so much more to not just heal the sick, but to prevent illness in the first place and elevate the already healthy.

We’ve already backed some of Human 3’s genre-defining companies like @KernaLabs , @motifneuro, @Psylo_Bio, NeuroBionics, Kadence Bio, @superpower and Aperture Therapeutics, at their earliest stages. We’ve helped them secure pharma partnerships, hire their best talent and raise millions in follow-on financing and we’re just getting started.

If you're a founder starting something in Human 3, we hope you'll consider working with @samalanascience and me.

[brom @therealbrom]

> my wife and I stopped by Corgi Cafe on Friday night to check the hype

> place was absolutely packed, there were two guys sitting nearly on top of each other in a phone booth because there were no seats

> three women in total: the barista, my wife, and a girl who was trying to get work done but kept getting hit on by a guy in a suit who told he her owned the cafe ☠️

[(AK) Akshit | Epoch Protocol 🦇🔊🛡️ @OstwalAk]

Corgi single-handedly is the best coworking cafe/space in my opinion.

I’ve been in SF for a week now and couldn’t find anything better than this cafe.

It’s 11 PM Friday night in SF, and this is the vibe at Corgi Cafe.

They offer high-protein smoothies (42g), with Chipotle and Subway nearby. The cafe is open 24/7 and has good WiFi.

What else do you need??

Gonna miss this energy and place in NYC so much

[brom @therealbrom]

@KadenceBio

[Duygu Figen @duygufigen18]

Seks esnasında erkeklerin çoğu genellikle 2,5 ile 6 dakika arasında boşalır; bu son derece yaygın bir durumdur.

Erkeklerin yaklaşık %95’i erken boşalmaktan kaygı duyar. Bu yüzden boşalmayı geciktirmek için birçoğu yavaş hareket etmeyi tercih eder, fazla heyecanlanmamaya özen gösterir.

Ne var ki bu çaba, aslında oldukça kötü bir cinsel deneyime yol açar.

Kadınlar ise genellikle 10-15 dakika boyunca ritmik ve düzenli hareketlerle orgazma ulaşmayı bekler.

Peki bu problemi nasıl çözeceğiz?

[brom @therealbrom]

@carolinetoch @investing_law is the man

[brom @therealbrom]

*rust developers in shambles*

[Elon Musk @elonmusk]

SpaceX has almost finished writing V1.0 of an in-house AI training stack in C that exact-maps to 220k GB300s with 800G NICs, making heavy use of pipeline parallelism and getting as close to bare metal as possible.

The potential speed improvement vs JAX for large training runs is over an order of magnitude.

[brom @therealbrom]

being in Chicago for a few days has made me realize how insanely early we are in the GLP-1 adoption cycle

[brom @therealbrom]

@_ramsaybrown Roses are red, violets are blue . . .

[brom @therealbrom]

Fellas, I hate to be the bearer of bad news, but most girls don’t want a skinny peptide boy

[brom @therealbrom]

@iPaulLee when I was raising my first fund, I thought that lowering fees would help me get commitments, but not once did I ever speak to an LP who was like 'I wont invest, but I will if you lower the fees'

[brom @therealbrom]

A great look at @coherenceneuro, a company we've been backing since 2024.

Coherence is actually building something useful for a real market; the thousands of people who get diagnosed with glioblastoma - one of the deadliest brain cancers - each year.

[Sachin and Adam @Sachin_and_Adam]

We got exclusive access to the startup building BCI’s for brain cancer survival

Two Cambridge engineers, @WoodingtonBen & @Elise__Jenkins, taking their SOMA-1 implant to human trials this month

This episode profiles @coherenceneuro and their Palo Alto research lab (featuring a live BCI mice demo) to learn about this new form of cancer treatment

Chapters
0:00 What is glioblastoma cancer?
3:17 Meet the founders - Ben & Elise
5:55 Inside the SOMA-1 device
6:56 How Coherence Neuro started
9:35 Why this technology is needed ASAP
11:22 Live Demo: Inside Coherence's Lab
14:53 Why MRIs (and other current tech) isn't good enough
15:50 When will patients have access to SOMA-1?
17:30 A future where cancer isn't terminal

[brom @therealbrom]

@alexkshieh @AntifraudCo this is pretty cool, but would be even more based if it was focused on suing the government when they defraud the american people

[brom @therealbrom]

@mhdempsey incredible post

[brom @therealbrom]

@DStrachman well, given the rarity with which most investors respond to updates, I can't blame founders for not wanting to write them lol

although in my limited experience, both the best, and the worst, and the middle of the road founders are all approximately equally lax with updates 😭

[brom @therealbrom]

*hits invest button

[hydra @HydraRare]

they should invent whoop but for actually living and having fun

it should track your nicotine + blood alcohol levels and then you could compare them with your friends on a leaderboard

[brom @therealbrom]

@arcticinstincts I met a guy at a party once who told me that he had zero training in physics, but was "shown" during a DMT trip how to make a warp drive.

Probably legit

[brom @therealbrom]

Long

[Conner O'Malley @conner_omalley]

Irish Zionism

[Conner O'Malley @conner_omalley]

Irish Zionism

[brom @therealbrom]

One of my favorite parts of being an atheist is that I don’t have to invent ways to excuse or downplay this type of depravity

[The Jerusalem Post @Jerusalem_Post]

A two-week-old baby was hospitalized at Wolfson Medical Center with a severe herpes infection after contracting the virus during a brit milah (Jewish ritual circumcision) that involved direct oral suction.
https://t.co/CQBp6my2qI

[Gwart @GwartyGwart]

Why don’t they just tokenize the oil in the Middle East and transport it across permissionless financial rails, thereby avoiding the Strait of Hormuz altogether