TH is the rate-limiting enzyme in dopamine synthesis and the primary marker for mapping dopaminergic neurons in the brain. In Parkinson’s disease research, visualizing TH-positive cell bodies can help reveal neuronal loss, circuit-level changes, and therapeutic effects. 1/
This visualization shows whole-brain tyrosine hydroxylase (TH) staining in a cleared mouse brain, revealing dopaminergic neuron cell bodies and projections at cellular resolution throughout the intact brain.
This sample captures TH-positive cell bodies and projections at cellular resolution. Imaged by @UMich student and @BioTranslucence undergraduate intern Nathan Hyman on a @zeiss_micro#Lightsheet Z.1.
Traditional 2D histology relies on destructive microtome slicing, which introduces sampling bias and severs neural pathways. This often results in imprecise measurements of amyloid plaques and α-synuclein.
Connect with @BioTranslucence during @adpdnet 2026 in #Coppenhegan next week to discuss novel whole-brain measurement techniques. Our Co-Founder and CEO, Damian Wheeler, and Director of Products and Business Development, Nathaniel Guanzon, will be presenting.
Join @BioTranslucence during #ADPD2026 in #Copenhagen for a discussion on brain-wide imaging and quantification techniques for the evaluation of #CNS therapeutics and disease pathology in intact tissues. Presentation and poster details coming soon! @adpdnet
Join CEO, Damian Wheeler, and Director of Products and Business Development, Nathaniel Guanzon, at #ADPD2026 as they present recent work applying our brain-wide measurement techniques to the evaluation of CNS therapeutics and disease pathology in intact tissue.
Happy Thanksgiving from the team at @BioTranslucence! We are grateful for the opportunity to support our friends and colleagues in their work. May everyone have a safe and joyful holiday.
Happy Thanksgiving! We are thankful for all of our amazing clients, colleagues, and collaborators! Wishing everyone a safe and happy holiday.
P.S It's a great time of year to try out the new Translucence Biosystems Turkey Tissue Clearing Protocol 😉
Join team @BioTranslucence at #SfN25 in San Diego. We'll be presenting posters on high-throughput imaging, tissue-clearing, and machine learning tools for whole-brain quantification. Poster details coming soon. See you in November, @SfNtweets! 🧠
We are excited to announce we'll be attending #SfN25 in #SanDiego, California, from Nov. 15-19. Visit Translucence Biosystems at Booth #3224 to learn about our latest advances in whole-brain imaging and tissue clearing.
@BioTranslucence's modified iDISCO+ protocol enables researchers to clear a wide range of tissues, including mouse brain, lung, liver, spinal cord, and more, while preserving three‑dimensional structure. 1/4
We are excited to highlight tissue clearing data generated by Dr. Ian Smith @UCIrvine. This cleared mouse brain sample, stained for amyloid (Amylo-Glo, green) and capillaries (cyan), reveals the brain’s microvascular network and amyloid pathology in intact tissue.
These kits provide a versatile option for a range of research applications and require no prior experience or specialized lab equipment to get started.
Translucence Tissue Clearing Kit users also gain access to discounted AI-powered quantification services.
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UC Berkeley researchers, students, and individuals interested in light sheet imaging and 3D histology are encouraged to join.
Participants will gain actionable knowledge on how these techniques can accelerate their research.
Registration details:
https://t.co/z6cH7hkGjG
We’re hosting an introductory Lunch & Learn event next month, providing a primer on tissue clearing techniques and applications, alongside the UC Berkeley Cancer Research Laboratory Molecular Imaging Center (MIC).
The event is open to all and free to join.
Join us for a Lunch and Learn, hosted in collaboration with the Molecular Imaging Center at the @UCBerkeley Cancer Research Lab. You'll learn tissue clearing best practices and how it's transforming biological research, followed by a Q&A session.
RSVP:
https://t.co/vfSY6PtcwA
Join us at the Tissue Clearing Workshop at @harvardmed, hosted by MicRoN, on Feb. 10–12, 2025!
This 3-day workshop includes:
• Lectures on tissue clearing and expansion microscopy
• Hands-on instrument and software demos
• Poster sessions
• Networking opportunities