🚨 CAP 2025 Update Highlights! 💥 New recognition of Low HER2 and Ultra-Low HER2 🎯 Refined interpretation for faint/incomplete staining 🧩 Better alignment with targeted HER2 therapies ➡️ HER2 reporting is now more nuanced — every stain matters! #HER2Low#CAPUpdate#BreastPath
Here is a quick (very simplified) run-down of how to gross a breast lumpectomy specimen. Sample dictation included at the bottom. Gross photos to be posted in the near future. Check out the full post below!
https://t.co/sEzp6zegXy
#Iheartpathology#PathTweetAward#BreastPath
1/ 🚨NEW: Updates in Triglycerides
A practical approach to elevated TGs, from knowing when to check ApoB or non-HDL-C to choosing lifestyle changes, medications, and when to suspect an underlying genetic disorder.
🎧: https://t.co/JdGmmyAB5K
📝: https://t.co/nsq8xKzhrg
Iron deficiency diagnosis in 2026:
• Ferritin ≤20 ng/mL: children 9 mo–4 y
• ≤30 ng/mL: most adults
• ≤50 ng/mL: selected higher-risk patients
• In inflammation: use ferritin + TSAT; consider TSAT <20% or ferritin <100 ng/mL
Normal Hb/MCV does not exclude iron deficiency
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SERUM IS NOT SIMPLY PLASMA MINUS FIBRINOGEN
Plasma is the liquid portion of anticoagulated blood. Serum is the liquid that remains after blood has clotted.
During clotting, the liquid phase is remodeled:
1/14
I saw a patient last week with a hemoglobin of 4.3 g/dL.
Sitting comfortably.
Normal oxygen saturation.
Normal blood pressure.
Heart rate in the 70s.
How can the body tolerate such a profound reduction in oxygen-carrying capacity?
A physiology thread. 🧵
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WHAT DOES COPPER HAVE TO DO WITH IRON?
More than I realized.
Copper-dependent ferroxidases help move Fe from cells → transferrin → erythron.
So copper deficiency can impair Fe delivery even when Fe is present.
And that’s only one way copper deficiency causes anemia.
WHY DOES THE MENTZER INDEX WORK?
MCV/RBC count <13 → think thalassemia trait
MCV/RBC count >13 → think iron deficiency
Easy to memorize.
But there's physiology hiding inside the formula.
Here's a thought experiment 👇
🆕 #AutoInflammatory / Periodic Fever Syndromes
In Memory of Dr. Dan Kastner🕊️
So grateful Dr. Kastner agreed to review this graphic >1 year ago, providing thoughtful input and suggestions to improve the final version 🙏
New Board Review Series for Rheum OnePagers 📟
#RheumX
COMPREHENSIVE MYELOMA and PLASMA CELL DISORDERS REVIEW ARTICLE THREAD. Bookmark.
A collection of our recent review articles on the spectrum of plasma cell disorders.
1/ MGUS @NEJM
Link: https://t.co/y9cHVaPZgH
Google just released free 2-hour course on full agent engineering: 1 prompt → agent teams → loops → graphs from 0% to 100%:
10% → 38:46 - build your first agent
30% → 54:46 - connect MCP tools
55% → 1:12:43 - Loop engineering: 4 ways to run agents
70% → 1:20:57 - Graph engineering
100% → 2:22:31 - the full system that works while you sleep
most people build one agent and stop there - this is the full path to a system that runs without you from scratch
watch it today - then read the full graph engineering playbook below ↓
ICYMI: #OpenAccess! The fascinating history of papillary thyroid carcinoma nuclei: revelation of two nuclear morphologies—“Classical papillary” and “papillary-like”, with different pathobiologic characteristics
https://t.co/wtOPRCUr9M
#CytoPath#ENTPath@UPMCPathology
❄️Mastectomy
❄️My favorite song ( https://t.co/Nh1p2VrDoH ) 🎶
❄️ The gauze I placed between the slices did not appear in the video 🙈
❄️ It will be fixed overnight in 10% buffered formaldehyde solution
❄️Tomorrow I will share more... #PathTweetAward#grossognosis#macropath
Andrew Ng just released a 1-hour course on building multi-agent systems from scratch:
• 00:00 - Introduction to agentic AI
• 03:07 - Building your first graph from scratch
• 14:00 - Connecting tools, memory, and context
• 23:00 - Building with Google ADK
• 01:06:03 - Why graphs are the future
In 1-hour he shows exactly how to build an agentic knowledge Graphs that improves itself.
Most people are still doing all of this by hand.
Watch the session, then save the guide below.
Andrew Ng just released a 1-hour course on building agentic knowledge Graphs from scratch:
• 00:00 - Introduction to agentic knowledge Graphs
• 03:07 - Construction of agentic Graphs
• 14:00 - Architecture of multi-agent systems
• 23:00 - Building agentic graphs with Google ADK
• 01:06:03 - Why Graphsare the future of agentic AI
Worth more than 10 articles on loop engineering.
Watch it today, then read how to become a graph engineer in the article below.