Annabel Olson

PhD virologist, KSHV, vaccinia, kinases, epigenetic factors. Post-doc @FredHutch @UW science writer @FredHutch | Alumni: @UNLincoln @Concordia_MN

[Annabel Olson @AnnabelOlson9]

Researchers @fredhutch in the Paulovich lab evaluated the multi-omic landscape of ovarian cancer cells and discovered 5 novel subtypes of ovarian cancer and were able to predict chemo-refractory tumors with high specificity.
#scicomm #ovariancancer
https://t.co/zTSRGtib00

[Annabel Olson @AnnabelOlson9]

Research @fredhutch in the Mielcarek group found that treatment of blood stem cell donors with statin cholesterol-lowering drugs may reduce the incidence of graft-versus-host disease in transplant recipients.
#scicomm #donor
https://t.co/eP09vvTTFw

[Annabel Olson @AnnabelOlson9]

Researchers @fredhutch in the Nelson lab dissect how prostate tumor suppression can occur via over-abundant androgen hormones as opposed to prior standard of care, androgen deprivation.
#scicomm
https://t.co/AipLXoUyv0

[Annabel Olson @AnnabelOlson9]

Researchers @fredhutch in the Paddison lab improve the efficiency of single and multiple gene knockouts from hard to edit donor bone marrow cells and now provide this technique as a Hutch service (see article).
#scicomm
https://t.co/wjQCCLJyiF

[Annabel Olson @AnnabelOlson9]

Research @fredhutch from the Stoddard Lab found that the PaqCl enzyme produced by bacteria forms a tetrameric complex with phage DNA and undergoes a unique structural change to cut DNA which may influence what DNA gets sliced and diced.
#scicomm
#bacteria
https://t.co/bBl8BIky2V

[Annabel Olson @AnnabelOlson9]

Researchers @fredhutch found that stabilizing mutations can have different impacts on models of peptide presentation complexes that are on the cell surface and highlight the "Dos" and "Don'ts" of designing such peptide HLA-I single-chain trimers.
#scicomm
https://t.co/dY384WTBot

[Annabel Olson @AnnabelOlson9]

Research @fredhutch in the Robert Bradley Lab @bradleybio @emma_hoppe extends the field's understanding of gene processing by mapping 100 regions of RNA with recusive splice site features and discovering such sites in unexpected places.
#scicomm
https://t.co/IGJmVUsRLu

[Annabel Olson @AnnabelOlson9]

Reseach @fredhutch in the Lee Lab @jklee_lab @vipulbhatia24 found that treatment with synthetic IL-12 cytokine boosts anti-tumor immunity and enhances the potency of STEAP1 targeting CAR T cell therapy for treating metastatic prostate cancer.
#scicomm
https://t.co/cRE8lAsbf7

[Pascal Geldsetzer @PGeldsetzer1]

Biggest thing to ever come out of my little group. Pls help spread this finding!

We found clean, CAUSAL evidence that the shingles vaccine prevents a good chunk of dementia cases. So, could a virus cause Alzheimer’s->YES!

Hear me out & see preprint: https://t.co/25f5XFQj8R
🧵1/

[Joss Landazuri @Viral_Joss]

🚨Spotlight alert🚨

The Nabet lab used PROTACs to degrade oncoproteins!!

El lab de Nabet usa el sistem PROTACs para degradar oncoproteínas!

Want to know more? Go and check it out!!!👇🏽👇🏽👇🏽👇🏽

https://t.co/RN4oEPlkpf

@fredhutch @Telemundo

[Annabel Olson @AnnabelOlson9]

Link here to spotlight article: https://t.co/wO2hdk1Uqp

[Annabel Olson @AnnabelOlson9]

The nimbus 2000 of predicting protein interactions is here! Phil Bradley's lab @fredhutch adapted the AlphaFold model to use structure and sequence data for predicting protein-peptide "binders" versus "non-binders".
#scicomm https://t.co/wO2hdk1Uqp

[Annabel Olson @AnnabelOlson9]

The Ortblad lab @fredhutch published their work showing that HIV PrEP-related counseling and dispensing from private pharmacies in Kenya provides an effective option for clients to receive care in addition to the public health clinics.
#scicomm #hiv
https://t.co/TdWVZw02fG

[Annabel Olson @AnnabelOlson9]

"Education is not a dialogue, as in a counseling situation.

Nor, on the other hand, is it a hierarchy in which the student is subordinate to the teacher handing down truth to him.

Instead, both student and teacher are always subordinate to the demands of truth."
-Ian Barbour

[Annabel Olson @AnnabelOlson9]

The Geoffrey Hill lab @fredhutch discovered a lethal combination for multiple myeloma relapse - lenalidomide standard of care drug synergizes with the inhibition of immune check point protein TIGIT.
#scicomm
https://t.co/7aByXT32O9

[Annabel Olson @AnnabelOlson9]

Research @fredhutch and @seattlechildren developed a feasible and well tolerated localized CAR T cell therapy and delivery method for children with fatal brain tumors.
#scicomm
https://t.co/WhkrMTxxi6

#SciArt by Katie Vicari
https://t.co/7jfJ29OOJt

[Annabel Olson @AnnabelOlson9]

Researchers @fredhutch including @agartland generated a mosaic HIV protein from circulating strains and demonstrated that the mosaic immunogen boosted the breadth of T cell immune responses.
#scicomm

https://t.co/UgBuz3wnIS

[Annabel Olson @AnnabelOlson9]

Researchers @fredhutch demonstrated in mice that the microbiome suppresses immune responses following DNA-platform vaccination but enhances those elicited by mRNA-baser vaccines.
#scicomm

https://t.co/4QcFkuJYtI

[Annabel Olson @AnnabelOlson9]

Selecting your mentors wisely and deciding to mentor others seems to be a trend for success and work-life balance. I agree that I've only achieved what I have because of supportive family/friends and academic mentors @Concordia_MN @UNLincoln @fredhutch

https://t.co/CQchvvilZR

[Annabel Olson @AnnabelOlson9]

@behnamnabet @fredhutch I'm looking forward to this new track of dissecting mechanisms of cancer signaling!