Annette Thompson

A girl exploring the world with her dog. I’m passionate about Claude Code, SEO, fitness and longevity research.

[Carl Hindy, Ph.D. @DrCarlHindy]

Avoiding conflict erodes intimacy.

This isn’t an argument for fighting. Conflict for its own sake damages relationships too.

But when we routinely swallow hurt, hide disagreement, or keep the peace at the expense of honesty, we create distance.

Intimacy requires enough safety to say, “Something between us isn’t right.”

Real intimacy isn’t the absence of conflict. It’s the absence of hiding.

[Dr. Rhonda Patrick @foundmyfitness]

I use exogenous ketones. But not everyday.

I use them strategically, especially before situations when stress could interfere with how clearly I think.

Human studies suggest that exogenous ketones such as beta-hydroxybutyrate may have anxiolytic effects and support cognitive function during stress. One proposed reason is that ketones influence inhibitory signaling involving GABA and adenosine, which may help quiet some of the "mental noise" produced by anxiety.

Before a major presentation or podcast, I'll take about 10 mL of a liquid beta-hydroxybutyrate ester (about 3-5 grams of ketones). For me, it helps calm some of that anxiety and improves my focus and attention.

I view exogenous ketones as a situational tool, not a daily supplement, and I've found them extremely helpful when I need to perform under pressure.

[Bo Wang @BoWang87]

Moderna/Merck just ran a 1,137-patient Phase 3 trial where every single dose was unique to that patient's tumor. It worked.

The pipeline: surgical resection → whole exome + RNA sequencing → ML neoantigen ranking → mRNA encoding up to 34 patient-specific targets → manufactured and shipped in 8 weeks. One drug, different sequence for every patient.

The ML step is worth to note: the algorithm ingests WES + RNA-seq to identify somatic mutations, then predicts which of those will actually be immunogenic, ie, displayed on tumor cell surface and trigger a T-cell response. It's designed to keep learning from accumulated clinical and immunogenicity data across patients, not just per-patient.

INTerpath-001 (Stage IIB-IV resected melanoma, 2:1 randomized): combination with pembrolizumab beat Keytruda alone on both primary (RFS) and key secondary (DMFS) at interim. Phase 2b at ASCO 2026 showed 49% reduction in recurrence/death, 59% in distant metastasis/death at 5 years. Phase 3 confirmed both.

What this validates:
— tumor-specific neoantigen prediction by ML works in a blinded trial at scale
— 8-week personalized mRNA manufacturing is operationally real
— effect is additive on PD-1 blockade, not redundant

This is first positive Ph3 for individualized neoantigen therapy. First positive Ph3 for any mRNA cancer therapeutic.

What a great time to live in!! This is the best time for AI & biotech!

[Moderna @moderna_tx]

Moderna and @Merck today announced positive topline results from the Phase 3 INTerpath-001 trial evaluating adjuvant treatment with intismeran autogene, a novel investigational mRNA-based individualized neoantigen therapy jointly developed by Merck and Moderna, in combination with KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 therapy, in patients with completely resected Stage IIB-IV melanoma.
Read more:

[Annette Thompson @annetteleethomp]

@AaronxShepherd Stack

[Annette Thompson @annetteleethomp]

@wanneracademy Snooze

[Annette Thompson @annetteleethomp]

@X_FINALBOSS X

[ALEX SUZUKI @X_FINALBOSS]

You can start an AI digital products business with $0 upfront and be making $15K–$80K/month within 90 days and nobody talks about how simple the actual setup is

here's the exact sequence:

Day 0: Pick a niche and audience. Women 35–65. Ecom operators. YouTube creators. Doesn't matter. Takes 3 minutes.

Day 1: Use AI to generate a 200-page ebook on that niche's #1 pain point. Takes 15 minutes. Price it at $300.

Day 2: Create an X theme page for that niche. Faceless. AI-generated content. Takes 10 mins to set up.

Day 3: Use AI to generate 300 tweets in 15 minutes. Schedule them out. Page runs on autopilot.

For 30 days, post 3–5 times per day. Educational value. No selling yet. You're building what Twitter's algorithm rewards: consistent activity and engagement signals.

Day 30: Turn on the auto-DM software. Every person who likes or comments gets an instant personalized DM with a link to buy.

AI bots handle the entire conversation. Objections. Follow-ups. Closing. 24/7 without you touching it.

Results from one of my pages targeting women 35–65:

Without the system (random posting, no automation):
Sales: 0
Followers gained: minimal
Revenue: $0

Same niche, WITH the full system running:

Less than 5,000 total views on 1 post
17 sales at $300 each
$5,100 from a brand new page with almost no reach

The cost to build this entire operation: under $45/month in tools

The AI generates the content. The AI generates the product. The bots do the selling. You collect the money.

Here's the full sequence for maximum output:

Week 1: Set up page, generate ebook, load 300 tweets into scheduler
Week 2: Page posts automatically while you do nothing
Week 3: Layer in auto-DM software, connect to sales page
Week 4: First sales start hitting. Optimize the DM sequence.
Month 2: Add a second page in a second niche. Stack the income. then third. keep repeating.
Month 3: You have 3–5 pages each generating $15K–$80K/month

Total time investment after setup: 3-7 hours per week

Every "make money online" guru tells you to grind content manually, build an audience slowly, and hope something converts. Nobody mentions that AI can do 95% of the work and the pages that win aren't run by humans at all.

Because the gurus are selling you their time-for-money model. This is the leverage model. Completely different game.

if you want the full gameplan, then

comment "X" and I'll DM it to you
**must be following + retweet

[Annette Thompson @annetteleethomp]

@sammgrowth Clone

[Sam @sammgrowth]

this is just fucking insane

three men. one workout. none of them are real

i cloned one viral gym video into all three. same lunge, same caption, same sweat. different guy, different country. one prompt each

seedance 2.5 rebuilds any viral video frame for frame now. keep the motion, the audio, the text. swap the person and the place. you cannot tell its ai

now do the math on money

a gym app needs a mountain of native ugc every month. the old way is hiring 10, 20 influencers, briefing them, waiting weeks, paying every single one

or one 16 year old with seedance 2.5 and claude code pumps out 100 videos in an afternoon from his bed if he wants to

claude code writes the clone prompts, seedance makes the videos, i just pick the winners. thats how you clear $10k a month easy. not because its hard, because you out-produce an entire agency alone

comment "clone" and ill dm you the exact seedance 2.5 clone process, the master prompt and the money model (must RT + follow so i can dm)

if you run an app or a brand and want ai ugc like this made for you, launch a campaign on affiliate network below

https://t.co/envQlFGJiy

[Annette Thompson @annetteleethomp]

@whotfiszackk Hub

[Annette Thompson @annetteleethomp]

@cbwritescopy Send

[Annette Thompson @annetteleethomp]

@TechWith_Rachel System

[Annette Thompson @annetteleethomp]

@X_FINALBOSS X

[ALEX SUZUKI @X_FINALBOSS]

You can start an AI digital products business with $0 upfront and be making $15K–$80K/month within 90 days and nobody talks about how simple the actual setup is

here's the exact sequence:

Day 0: Pick a niche and audience. Women 35–65. Ecom operators. YouTube creators. Doesn't matter. Takes 3 minutes.

Day 1: Use AI to generate a 200-page ebook on that niche's #1 pain point. Takes 15 minutes. Price it at $300.

Day 2: Create an X theme page for that niche. Faceless. AI-generated content. Takes 10 mins to set up.

Day 3: Use AI to generate 300 tweets in 15 minutes. Schedule them out. Page runs on autopilot.

For 30 days, post 3–5 times per day. Educational value. No selling yet. You're building what Twitter's algorithm rewards: consistent activity and engagement signals.

Day 30: Turn on the auto-DM software. Every person who likes or comments gets an instant personalized DM with a link to buy.

AI bots handle the entire conversation. Objections. Follow-ups. Closing. 24/7 without you touching it.

Results from one of my pages targeting women 35–65:

Without the system (random posting, no automation):
Sales: 0
Followers gained: minimal
Revenue: $0

Same niche, WITH the full system running:

Less than 5,000 total views on 1 post
17 sales at $300 each
$5,100 from a brand new page with almost no reach

The cost to build this entire operation: under $45/month in tools

The AI generates the content. The AI generates the product. The bots do the selling. You collect the money.

Here's the full sequence for maximum output:

Week 1: Set up page, generate ebook, load 300 tweets into scheduler
Week 2: Page posts automatically while you do nothing
Week 3: Layer in auto-DM software, connect to sales page
Week 4: First sales start hitting. Optimize the DM sequence.
Month 2: Add a second page in a second niche. Stack the income. then third. keep repeating.
Month 3: You have 3–5 pages each generating $15K–$80K/month

Total time investment after setup: 3-7 hours per week

Every "make money online" guru tells you to grind content manually, build an audience slowly, and hope something converts. Nobody mentions that AI can do 95% of the work and the pages that win aren't run by humans at all.

Because the gurus are selling you their time-for-money model. This is the leverage model. Completely different game.

if you want the full gameplan, then

comment "X" and I'll DM it to you
**must be following + retweet

[Annette Thompson @annetteleethomp]

@maxxmalist Sedance

[MAX @maxxmalist]

i just figured out how to get flawless generations in Seedance 2.5 every single time

every generation costs real money and one vague prompt means you're paying for a clip that goes straight to trash

i burned through more credits than i want to admit before i figured out the fix, a single prompt template that comes back CLEAN every time, 30 second continuous shot, character locked, camera doing exactly what i wrote, nothing random in the frame

the difference is structure, the model reads timestamps, reference assets and constraints way better than loose descriptions, so i stopped describing vibes and started scripting seconds

i packaged my entire template and i'm giving it away today:

-prompt template for full 30-second videos (first try output, no rerolls)
-the reference asset setup that keeps characters locked across the whole clip
-my negative prompt list that kills 90% of weird AI artifacts
-how to run 2.5 without torching your budget

RT + reply "SEEDANCE" and i send it over (must follow so i can dm)

it’s coming soon to higgsfield, so bookmark this, you’ll need it

[Annette Thompson @annetteleethomp]

@rosemoni18 Kdp

[Annette Thompson @annetteleethomp]

@maverickecom Affiliate

[Annette Thompson @annetteleethomp]

@fivosaresti Engineer