This has quietly been a miracle month in medicine.
In the last 5 weeks we’ve got news on:
- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors
This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.
@levelsio Conflicted between the incentives that actually would drive people to perform and the kind of credit score system you are suggesting that aims for control of populations
Just launched my first product motivated by @levelsio
Painel dos Recibos is a BI platform for portuguese freelancers. Check it out:
https://t.co/hnNpZpoZ5O
how to build a bootstrapped startup without funding:
1. pick a problem you personally have. if you don't use your own product daily, quit now
2. skip the pitch deck. open your code editor. ship something ugly in a weekend
3. charge money from day 1. free users give you nothing but support tickets
4. use boring tech. PHP, SQLite, vanilla JS. frameworks are a trap that mass waste your time
5. host on cheap VPS ($5-20/mo). not AWS. you don't need kubernetes for 1,000 users
6. do customer support yourself. it's the fastest product feedback loop that exists
7. automate everything you do more than twice. cron jobs > employees.
8. grow on Twitter/X by building in public. your journey IS the marketing
9. keep your burn rate near zero so you never need to raise. ramen profitable > series A
10. say no to investors, cofounders, and "advisors" who want equity for intros
i've been doing this for 10+ years now. no employees, no funding, no board meetings
the entire VC game is designed to make you think you need permission to start
you don't
@levelsio Just launched my first product motivated by @levelsio
Painel dos Recibos is a BI platform for portuguese freelancers. Check it out:
https://t.co/hnNpZpoZ5O