How might SGLT2 inhibitors mediate cardiorenal benefits beyond glucose lowering?
https://t.co/qsX8AtsguY
Abdualrahman Mohammed Abdualkader @armak1983 Rami Al Batran @AlbatranLab & team @UMontreal report that SGLT2 inhibitors boost ketone production by directly activating a liver enzyme.
The cover image shows the crystal structure of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) homodimer (rainbow ribbons) bound to empagliflozin (gray sticks).
#SGLT2i #Ketogenesis #CardioMetabolic #KidneyDisease #LiverMetabolism
@armak1983@AlbatranLab@UMontreal Behind the scenes: Dr. Abdualkader @armak1983, a pharmaceutical chemist and Research Associate at Université de Montréal, works at the interface of drug design for the management of metabolic disorders.
@amdo1984 @jdpereira I completely agree with you. Having worked in the industry for three years before transitioning to academia for the past two years, I have experienced firsthand how academic life is becoming increasingly burning and stressful.