📍 Metformin - direct GI mucosal irritation on empty stomach - nausea + diarrhoea + epigastric discomfort; take with food - extended-release formulation significantly reduces GI intolerance
📍 Colchicine - direct GI mucosal irritation + microtubule disruption in rapidly dividing enterocytes - nausea + vomiting + diarrhoea amplified on empty stomach; GI toxicity is the built-in dose-limiting signal
📍 Corticosteroids - reduce mucosal prostaglandins on empty stomach - gastric epithelium unprotected - irritation + erosion + ulceration risk; always take with food to buffer direct mucosal contact
📍 NSAIDs (Ibuprofen, Naproxen, Diclofenac) - COX-1 inhibition removes prostaglandin-mediated mucosal protection + direct epithelial irritation on empty stomach - gastric erosions + epigastric pain; food + PPI cover mandatory with chronic use
Ulcer is NOT caused by:
1. Peppery and spicy foods
2. Going on hunger strike
3. Drinking orange juice
4. Stress
If this is what you believed, you have been lied to.
Here's the REAL truth about Ulcer:🧵
Natural Ways to Handle Constipation
Struggling to empty your bowels can be uncomfortable and frustrating. The good news is that many cases of constipation can be solved naturally, no pills needed.
Below are easy, natural ways to stop constipation:
5️⃣ Why You Should NEVER Self-Medicate with Ciprofloxacin
❌ Antibiotic Resistance– Misuse leads to bacteria becoming resistant, making future infections harder to treat!
❌ Wrong Diagnosis– You might not even need an antibiotic! Taking it unnecessarily can harm your health.