Glad to see this research highlight in @NatureInd on our recent work.
The current 2.3.4.4b clade #H5N1 is unusual and spreading rapidly in mammals and shows human adapting potential, a #OneHealth concern, needs more attention. https://t.co/kHH4TVYdO7
A new study by researchers at IISc offers insights into cell death regulation by viruses like SARS-CoV-2, and how bats and humans respond differently to tricks that such viruses use to manipulate the host’s defense.
https://t.co/9R3r92bkBY
#IIScresearch
Our recent work: Identified #viralRHIMs in RNA viruses originated from #bats, including SARS-CoV-2. Viral RHIM in SARS-CoV-2 #Nsp13 shows distinct cell death regulation in bat and human cells. Also, associated with Z-RNA sensing and #ZBP1-RIPK3 signaling.
Elated to share our work reporting functional #viralRHIMs in bat-RNA viruses and their regulation of ZBP1-RIPK3-associated cell death, now out on @iScience_CP. Huge thanks to @keshu_VRimmCh for guidance,@Disha__dak,#Ayushi for their efforts.@CellPressNews https://t.co/PX3oHosNme
New work: Decoding non-human mammalian adaptive signatures of 2.3.4.4b #H5N1 to assess its human adaptive potential.
We aim to understand the non-human mammal adaptations of panzootic 2.3.4.4b H5N1 and assess the human adaptive potential of 2.3.4.4b H5N1
https://t.co/ycemfv3u0b
New work: Decoding non-human mammalian adaptive signatures of 2.3.4.4b #H5N1 to assess its human adaptive potential.
We aim to understand the non-human mammal adaptations of panzootic 2.3.4.4b H5N1 and assess the human adaptive potential of 2.3.4.4b H5N1
https://t.co/ycemfv41PJ
A Green and Bright Day at @iiscbangalore
Our lab picture at IISc.!!
Our group is interested in investigating the Emergence of Pandemic viruses, Reservoir host Biology, Z-RNA sensing and Cell Death.
@BICS_IISc
This discussion might need few more facts to considers.
First, the 2.3.4.4b H5N1 is a novel strain. Got new changes on surface proteins (HA and NA).
H5 HA shows 6 or 7 glycosylation site (GLS) patterns unlike previous strains having 8-9 GLS.
https://t.co/sgNo7kkMzA.
2.3.4.4b #H5N1 has been spreading rapidly & infected several #mammal species, including #cattle. This work reveals molecular virologic factors leading to 2.3.4.4b H5N1 emergence & a new molecular program deciding avian flu HA & NA pairing. @iiscbangalore