Our Gynecologic Pathology cases @UMiamiPathology are fascinating! Here’s a striking example of pilomatrix-like high-grade endometrial carcinoma (PiMHEC), a recently described entity mostly driven by CTNNB1 mutations. Look for solid basaloid growth with conspicuous central tumor cell necrosis, and pilomatrix-like keratinization with the hallmark ghost cells. This case also had a focal conventional FIGO grade 1 endometrioid component. IHC shows diffuse nuclear β-catenin with loss of PAX8 and ER in the pilomatrix-like component. These tumors are believed to behave aggressively.
We are excited to gather for the 7th Annual Allan Tucker Pathology Resident Research Forum to witness the outstanding research projects presented by our residents.
A resident-driven scientific innovation and academic achievement.
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#Pathology#ResidentResearch#PathTwitter
#Path_resident_teaching_pearl 🧠
: Arias-Stella reaction in endometrial biopsy
🔍 Key histologic clues:
• Marked nuclear enlargement with hyperchromasia
• Vacuolated / clear cytoplasm, sometimes hobnail-like cells
• Preserved overall architecture (no destructive stromal invasion)
• Low mitotic activity despite striking atypia
• Background of gestational or high progesterone state
⚠️ Common pitfalls:
• Overcalling as clear cell carcinoma or serous neoplasia
• Misinterpretation in ectopic pregnancy or early intrauterine pregnancy
• Focusing on nuclear pleomorphism without considering clinical context
🧩 Pearl: “Atypia out of proportion to behavior”, always correlate with pregnancy history and hormone status.
#Pathology #GYNPath #PathX #pathtwitter #DiagnosticPitfalls
Happy to share the news that our E-cadherin article received enough views to be a Top Viewed Article in Histopathology.
Read it here https://t.co/r02lExjV9J #TopViewedArticle@wileyinresearch@RezaTaha_
🎉 We are excited to congratulate Dr. Jiang PGY-1 for being awarded the Paul E. Strandjord Young Investigator Award by the Academy of Clinical Laboratory Physicians and Scientists (@ACLPS_ ) and Dr. Barouqa for his vision and mentorship!
#ACLPS2026#PathX#MedX#Pathresidents