Excited to share our work on mechanisms of oxygen toxicity! As a @UCSFCardiology fellow, I wondered why excess supplemental oxygen is associated with adverse outcomes. Here we take a deep dive into O2 toxicity. https://t.co/iKpK6Vfn3B @UCSF@GladstoneInst@ishahjain
I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth.
This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF.
https://t.co/bzsPY2nWVs
The Baik Lab at UCSF (CVRI) is hiring a post-doc! We study hypoxia adaptation in cardiovascular disease and mechanisms of cancer therapy-related cardiotoxicities. Collaborative culture, strong mentorship, and innovative approaches! Email CV + cover letter to [email protected]
Check out our case of acute radiation-induced pericarditis complicated by polymicrobial infectious pericarditis in a patient with mediastinal sarcoma: https://t.co/gqsaD4LNyl
Mentored by the amazing @baik_alan#CardioOnc#UCSFCardiology
Our new paper: https://t.co/MRnzs0PocQ! @kirsten_chenx et al. looking at in vivo protein turnover vs O2. We confirm our previous work that C1 stability is O2-sensitive and nominate MYBBP1A as a mediator of the hyperoxia response (HIF for hyperoxia?)
News: https://t.co/34E5VHltLd
Happening now at #AHA23 - the promise and perils of the omics revolution in cardio-oncology. Great talk by Jose Fuster on CHIP mutations and increased risk of CVD @AartiAsnaniMD@SvatiShah@AHAScience
Big congrats to Section of #CardioOnc & Immunology faculty member @baik_alan in being promoted to Assistant Professor of Medicine at @UCSF! Alan's research revolves around manipulating hypoxia in #CardioOnc including w/ HIF2 inhibitors (e.g., belzutifan)! @UCSFCardiology
Big congrats to Section of #CardioOnc & Immunology faculty member @baik_alan in being promoted to Assistant Professor of Medicine at @UCSF! Alan's research revolves around manipulating hypoxia in #CardioOnc including w/ HIF2 inhibitors (e.g., belzutifan)! @UCSFCardiology
Yesterday I shared @ishahjain's work on *low* oxygen. Today, she, @baik_alan & @kirsten_chenx have a paper in @MolecularCell on why *high* oxygen is harmful. Her @GladstoneInst@UCSF team discovered that too much O2 "rusts" proteins w/ sulfur & oxygen.
https://t.co/lo0xrRJVY7
Excited to share our work on mechanisms of oxygen toxicity! As a @UCSFCardiology fellow, I wondered why excess supplemental oxygen is associated with adverse outcomes. Here we take a deep dive into O2 toxicity. https://t.co/iKpK6Vfn3B @UCSF@GladstoneInst@ishahjain
Hyperoxic injury to the ETC results in higher levels of unused oxygen, further exacerbating cellular and tissue toxicity. Important implications for mitochondrial disease, oxidative stress, aging, I/R injury!
For anyone interested in #CardioOnc & #CardioImmunology, I highly recommend coming 2 this session #AHA22 on Saturday! A+ speakers & especially talk by @DrJESalem! It will provide a new paradigm for treating myocarditis patients! Game changer in the field! @UCSFCardiology