Elliot Bailey

Chemist. Formerly with @MDSgroup_Oxford, @DonohoeGroup, @conway_group & @OxfordChemistry

[Elliot Bailey @bailey_elliot]

Using Fe, Cu, Ru and Ir catalysts, low temperatures can enable (regio- and enantio-)selective alkylation with good functional-group tolerance. We also reflect on the limitations of the methods and offer an outlook on where this chemistry could go next.

[Elliot Bailey @bailey_elliot]

Our review with @DonohoeGroup and @MDSgroup_Oxford, is out now in ACS Catalysis (open access).

https://t.co/I5MgqE1Nfx

[Elliot Bailey @bailey_elliot]

We examine the surprisingly limited examples of metal-catalysed hydrogen borrowing C– and N-alkylation reactions that operate at room temperature (≤30 °C), in contrast to the high-temperature (80–200 °C) conditions that have dominated the field.

[Elliot Bailey @bailey_elliot]

Our work investigating the functional group tolerance of the hydrogen borrowing enolate alkylation method now out in full form! @MDSgroup_Oxford @DonohoeGroup

@OxfordChemistry @OxfordSynthesis

https://t.co/2BVHAQy4OW

[Patrick Brennan @PatrickJosephB]

Very pleased to share that my PhD work from @UniofOxford/@synbioCDT with @conway_group is now live on BioRxiv - we designed pairs of orthogonal IMiD analogues and ZF degrons for use in target validation & beyond. https://t.co/WFIbUn0faW

[Elliot Bailey @bailey_elliot]

@BagPhos @MDSgroup_Oxford @DonohoeGroup @OxfordChemistry Thanks for highlighting our work! :)

[Elliot Bailey @bailey_elliot]

(8/8) The advantage of ChemRxiv is being able to interact with the community before submission to a journal; we’re all very happy to hear any correspondence about the work (especially if we referenced you)!

[Elliot Bailey @bailey_elliot]

(1/8) Please to present our work on functional group tolerant C-C bond forming hydrogen borrowing enolate alkylation reactions with @MDSgroup_Oxford @DonohoeGroup @OxfordChemistry @OxfordSynthesis:

https://t.co/PMxrmufMDT

[Smith Group @MDSgroup_Oxford]

In @ChemRxiv we (in collaboration with @DonohoeGroup) show that hydrogen borrowing can be a remarkably mild and functional group tolerant process: https://t.co/GXdMiES1Ji Outstanding stuff from @bailey_elliot @OxfordChemistry @OxfordSynthesis

[Elliot Bailey @bailey_elliot]

(7/8) We observed a dominant dihydride species at room temperature, which could account for the lack of reaction under air at rt. We also observed decent reactivity with the modified catalyst (product of dihydride with air) at higher temperatures.

[Elliot Bailey @bailey_elliot]

Paper Link: https://t.co/PMxrmufMDT

[Elliot Bailey @bailey_elliot]

(8/8) The advantage of ChemRxiv is being able to interact with the community before submission to a journal; we’re all very happy to hear any correspondence about the work (especially if we referenced you)!