Carlo Contango

Feral being. Lazy sloth. Die Ian Die.

[Carlo Contango @barcalogia]

Everything sinclair is promoting i immediately become suspicious of it.. if reprogramming affects one of the first order causes of aging, we should see strong effect in animal models regardless of what else.. Same for senolytics.. If not, not worth pouring billions of $$ into it

[Antonio Regalado @antonioregalado]

There are many unpublished negative results trying to extend the lifespan of mice using partial epigenetic reprogramming.

[Carlo Contango @barcalogia]

Hopefully the competition in the east rises up, indiana coming back, boston improving, let's see what Orlando does, cleveland maybe, detroit definitely should be better, an likes of atlanta miami even Washington

[Carlo Contango @barcalogia]

They probably run it back as the most expensive team in the league pending on OKC shedding, bringing back robinson and shamit for 25-30M and the rest of rotation for 250m in salaries and additional 200m approx in luxury tax...

[Carlo Contango @barcalogia]

Not the best team, but the one that deserve it more. Funny how most of playing time spurs were better, finding better shots, driving into and passing outside.. Yet they'd inevitably find ways to throw it away at the end of games.

[Carlo Contango @barcalogia]

Remember OKC 2y ago, we all astounded in our gc to their shooting and rebounding flaws was to bring Hayward for free instead of trading for cam Johnson or any other shooting wing size player. You're going to win 5 theoretical rings till injuries other teams improving luck etc

[Carlo Contango @barcalogia]

While it's true playoff rotations are 9-10 guys deep, there's always injuries and guys falling off. There is no reason to have 3 centers in your roster who are 100% not going to play. What are you doing if champaigne loses a couple of games, play barnes for 32 minutes?

[Carlo Contango @barcalogia]

Also Spurs lack wing depth, maybe moving olinik for a guy like derick Jones or herb jones in February. Even portis or okoro may have been useful tools in this run. Had 4 tradable first rounds, and like 3 seconds every year. If you are a contender, can't wait and see.

[Carlo Contango @barcalogia]

doesn't help him. And the injury. But he's due a pretty expensive extension. EPM has him at 2.9, bottom of the top30 in the league, so deserving a max. But at 28, and always been Reliant on creating an advantage through the dribble, it may not age well.

[Carlo Contango @barcalogia]

Not the reason spurs are losing, but Fox is supposed to be the closer and he's failing at closing. Shooting percentages are 10% vs regular season for 2P, and he's like in the quickness and we saw in Sacramento to create the space. Also playoff physicality (grabbing and holding)

[Alex @ajak1033]

I’m speechless. I have no speech. The man himself had acknowledged me.

Thank you to everyone who’s liked, commented, reposted and reached out to me these past 36 hours. Never in a million years did I expect this to happen.

[Carlo Contango @barcalogia]

And from there so quickly again explosion of diversity.. While using the same building blocks and chemistry for all life on Earth, repurposing pathways cycles and molecules for a wide array of use cases. Or evolving very similar systems independently, like the circulatory system

[Carlo Contango @barcalogia]

The vital question is a great book on the origins of life, enjoyed all nick lane books, mindscape podcast has lots of episodes about it too..It's fascinating that apparently life appeared so quickly on Earth history, but it took so long for evolving complexity and multicellular..

[Carlo Contango @barcalogia]

Also it follows focusing on health and longevity is Paramount, minimizing disease and sickness, and maximizing the total amount of moments in our life

[Carlo Contango @barcalogia]

based on what you value and what it costs, not an absolute or arbitrary benchmark.. Like the characters of the abundance of less, great book btw, not much is necessary to enjoy a simple life.. The less you need, the more time and the less stress you have

[Carlo Contango @barcalogia]

Always been fascinated by life.. Diversity origins evolution.. What even is alive, viruses? But also, as a living being, the finitude of it, the experience of it, how to approach it from a subjective point of view, how to even live in the modern world of infinite choices..

[Carlo Contango @barcalogia]

it helps to remove the storytelling as much. That is focusing on the experiencing self and making life choices based on that, like living near nature if you enjoy it, living in a city if you value other things.. It also helps greatly in the issue of money, how much do you need..

[Carlo Contango @barcalogia]

From personal experience, when I paid sports subscription felt compelled to watch more than the optimal amount, instead of the "less convenient" approach of downloading it for free, which nowadays takes less than 20 minutes for 1080p trimmed game