Shaon Basu

[Ralser Lab @RalserLab]

https://t.co/ki7JQP0Kku Simran's metal ion manuscript made i to the cover of @CellSystemsCP . Always told everyone that metal ions rock :-)

[Ralser Lab @RalserLab]

Since the founding https://t.co/ZUWzzzHA7K, I get asked often how DIA-NN started. It was born out of the the need to analyse large yeast DIA proteomes recorded @TheCrick funded by the @BBSRC in a joint project with @lilley_ks, later by @bmbf. Aptila is a @ChariteBerlin spin off.

[Ralser Lab @RalserLab]

When #AlphaFold2 came out, we wondered: Could it help us understand how enzymes evolve? So we tried it—and it worked! https://t.co/rtGbSpeAvk

[Martin Picard @MitoPsychoBio]

Superb video of the mitochondrial community in a single cell—hundreds of squiggly microorganisms sensing, processing, and signaling energy and information

By @chillinwithpfn1
https://t.co/EG8Pk55Nwc

[Prof. Nikolai Slavov @slavov_n]

Timescales in Cell Biology

[Jonathan Henninger @jehenninger]

Check out our review on an RNA-centric view of transcription and genome organization in an #RNA-focused issue of @MolecularCell! It was a delight to write with @youngricka.

https://t.co/uxUeUa9705

[Aydan Bulut-Karslioglu @bulutkarslioglu]

Our new work is out today! Long time in the oven, this has been a really fun and informative collaboration led by Dhanur Iyer in my lab and @HK_Heidar from @NRivron lab. We show that human embryonic cells have an inherent potential to regulate their developmental timing.

[Denes Hnisz @dhnisz]

The @TheMarkFdn is an essential collaborator in this effort, as are @xsalvatella1, @PaulRobustelli and many other friends and colleagues @ShaonBasu @MPI_MolGen @IRBBarcelona!

[NedergaardLab @NedergaardLab]

Cerebrospinal fluid links the brain and peripheral sensory system and drives headache in migraine with aura! We’re excited to share our newest article just published today in @ScienceMagazine . Please read along:
https://t.co/ab3HuaTpYe

[Julian Naderi @Naderij_]

Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of @dhnisz, @VingronLab and Graf Lab published today in @NatureCellBio https://t.co/OkvRuF6nhT

[Julia Muenzner @JuliaMuenzner]

1/n I'm so very happy and excited that my main postdoc work is out now @Nature 😁 This was such a fun and rewarding project to work on - thanks Markus for letting me dive into the wonders of yeast and proteomics despite this being an almost 180° change from my PhD work.

[Ralser Lab @RalserLab]

Many will remember heavy debates in the yeast aneuploidy field. Are excess proteins dosage compensated, and if, how? Are there general signatures of aneuploidy? These problems solve studying natural strains. Time's back to study wild species, Biologists! https://t.co/lXYimEhQxG

[Shaon Basu @BasuShaon]

@matteo_ciciani Cas9 is indeed quite ordered. Nice to see it + the interaction with DNA!

[Shaon Basu @BasuShaon]

@pranamanam looks like the transformer paper :-) https://t.co/aZEHkqKnqF

[Shaon Basu @BasuShaon]

@karlrohe @lpachter presence of highly variable, homoscedastic, linear correlated and/or uncorrelated features, helps PCA be meaningful (atleast from EDA side). Have used it on data with non Gauss feature distributions, still informative, but harder to interpret loadings

[Takashi Fukaya @FukayaLab]

Delighted to share new review paper published in @TrendsCellBio ! We discuss emerging new models of enhancer functions, including our favorite 'transcription hub' model.
"Regulatory Landscape of Enhancer-mediated Transcriptional Activation." Link here: https://t.co/JRhR5eCl1Q

[Kresten Lindorff-Larsen @LindorffLarsen]

Happy to share the publication of our paper in @Nature

Conformational ensembles of the human intrinsically disordered proteome

Work led by @GiulioTesei and @AnnaIdaTrolle. I'll post more later, but for now here is a link:
https://t.co/b3aZ6BbGpB
and a short movie about the work

[MPI for Molecular Genetics @MPI_MolGen]

Hot #PhD topic: transcriptional condensates! Use #imaging, #biochemistry & #genomics to characterize phase separation of regulators & their roles in development and diseases. Join @dhnisz's lab & #IMPRS-BAC #gradschool!
✍️ https://t.co/FhkbPMtFQA @maxplanckpress

[Paul Robustelli @PaulRobustelli]

@JiaqiZhuDartmth and I are proud to contribute to a collaborative effort led by @xsalvatella1 to characterize the driving force of androgen receptor condensate formation and discover and characterize new inhibitors.

Out now in @NatureSMB

https://t.co/swsH7P7yoK

[xavier salvatella @xsalvatella1]

This article, much improved, is now published in @NatureSMB: https://t.co/ZReTm9dZNs. Thanks to all the authors who helped during the revision process !