Bax Group

Nuclear Magnetic Resonance Spectroscopy since 1983!

[Bax Group @bax_group]

How do you study what NMR can’t see?
Apply 2,500 bar of hydrostatic pressure! 💥
Our new @MethodsEnzymol chapter highlights #PressureJump #NMR for probing transient #Aβ #oligomers, mapping relaxation, NOEs, and Zn²⁺-stabilized assemblies in real time.

https://t.co/lSZkATXw15

[Bax Group @bax_group]

We show that #RDCs (#ProteinNMR) alone can quantify #ProteinDynamics using a multi-conformer, multi-tensor SVD approach. Application to apo maltose-binding protein reveals a low-population partially closed state. A web-based tool is provided. https://t.co/7huXGPYF5N

[Bax Group @bax_group]

Excited to have Tayeb’s Kakeshpour’s recent innovations now published in Analytical Chemistry. Tayeb used #NMR and #mass_spec to observe nanogram quantities of non-volatiles in #exhaled #breath, opening a new window in lung disease diagnosis.

https://t.co/kqKT2jY8rI

[Bax Group @bax_group]

#Snoring-generated #droplets can lead to #covid-19, #influenza, and #RSV #pneumonia through self-infection. Our study involved #NMR and #mass-spec. Snoring #aerosols are generated during inspiration, but a fraction remains detectable after exhalation. https://t.co/lit3BOxNMJ

[Bax Group @bax_group]

Our latest research published in @JMolBiol : We used #Pressure-Jump #NMRto show that non-native #proline isomers can lead to partially folded structures.
https://t.co/a5fYQf00O8
#High_Pressure_NMR #Protein_Folding #ubiquitin

[Bax Group @bax_group]

@Atmosphere_MDPI @jljcolorado @karlberggren
In this study, we show that commonly used methods drastically under-count medium sized #RespiratoryAerosols, with important implications for #modeling -- and prevention -- of #AirborneDiseaseTransmission.
https://t.co/3fqSUUEmVa

[Martin D. Gelenter @MartinDGelenter]

I'm excited to have our work on #melittin 🐝🐝 published in @J_A_C_S!!
We produced triply isotopically labeled native melittin and studied its structure at high resolution using #NMR combined with #AlphaFold-Multimer
https://t.co/tUXNNmoM1X

[Bax Group @bax_group]

Our aerosol measurements strongly suggest that snoring while suffering from an upper respiratory tract infection can lead to pneumonia

Snoring may transmit infectious aerosols from the upper to the lower r... https://t.co/omvy8jVs6h

[Bax Group @bax_group]

Given our recent work on #SARSCoV2 MPro (https://t.co/w9I865Ff4E) where we showed close agreement between X-ray structures, #AlphaFold2 models, and solution RDC data, the AF2 models of the #Omicron P132H are likely to be of high quality too. 4/4

[Bax Group @bax_group]

Running a @DeepMind #AlphaFold2 calculation for the #Omicron P132H mutation in #SARSCoV2 Main Protease gives very similar structure predictions to wild type. 1/4

[Bax Group @bax_group]

(Here is a labelled still from that video to help you figure out what's what) (3/4)

[Bax Group @bax_group]

Good agreement with structurally sensitive NMR RDCs for #SARSCoV2 Main Protease confirms outstanding performance of @DeepMind's #AlphaFold2, even when culling homologous models from its input.

RDCs may offer opportunity for further refinement.

https://t.co/w9I865Ff4E

[Bax Group @bax_group]

Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering

https://t.co/aEm65yFd65

[Bax Group @bax_group]

Our work using CEST #NMR to study Schiff base formation is newly published in @angew_chem! A combined effort from Venkatraman Ramanujam and @CyrilCharlier14.

[Charlier Cyril @CyrilCharlier14]

New paper on the Observation and kinetic characterization of transient Schiff base intermediates by CEST NMR in Angewandte Chemie #CEST #NMR https://t.co/2SYGOOh5MT

[Bax Group @bax_group]

Check out the new paper from our group on Aβ(1-40) using #PressureJumpNMR!

Great work from postdocs Ashley Barnes and @angusjrobertson with John Louis and Philip Anfinrud.

[Angus Robertson @angusjrobertson]

Pressure jump #nmr used to investigate initial oligomerization steps of amyloid-beta(1-40) just published in @J_A_C_S #nmrchat

https://t.co/En3BCixLwy

[Bax Group @bax_group]

Congratulations to Bax group member @CyrilCharlier14 for winning the @MagnResonChem young scientist's prize at @euroismar2019!

[Charlier Cyril @CyrilCharlier14]

Thanks @euroismar2019 for this great conference in Berlin! Honored to receive the @MagnResonChem for the young scientist's Prize! 🛫Now time to fly back to the US for the final 2 weeks of my Post Doc!