Labo de la Barrière Hématoencéphalique (LBHE)

The Blood-Brain Barrier Lab develops and uses in vitro BBB models for investigating BBB physiology, for improving drug delivery and for providing tox data.

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Félicitations à Océane Dusailly pour la soutenance de sa thèse et l'obtention du grade de Docteur en Sciences ! 👏 🥳 Bravo également à ses encadrants, les Dr. Saint-Paul et Pr. Tilloy-Fenart !
📷 #Doctorat #Recherche

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

📢A new study from the Dr. Pietra Candela combining the use of several in vitro models (human intestinal and blood-brain barriers models) as well the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) !!
Click there to read this wonderful work: https://t.co/Z8r3pKHADu

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

📢 Congratulations to the Pr. Fabien Gosselet for his last publication in Biomedicine & Pharmacotherapy ! 🥳
Link to access : https://t.co/Co4vAwIfK7

[William A. Wallace, Ph.D. @WilliamWallace]

Our brain isn’t just made of neurons. It runs on a whole neighborhood of cells that can either protect your mind or quietly push it toward inflammation.

This diagram reveals how astrocytes, microglia, neurons and oligodendrocytes talk to each other during stress, illness, and injury. Their conversations shape memory, mood, cognition, and long-term brain resilience.

Here is what this graphic shows in plain language:

🧠 Astrocytes act as the central switchboard
They decide whether the brain environment becomes supportive or inflammatory. When they sense danger signals, they activate NF kappa B and release molecules that influence the other cells around them. When conditions are safe, they release factors that help neurons grow and help new oligodendrocytes mature.

🔥 Microglia can protect or damage depending on the signals they receive
They can release IL 1 beta, GM CSF, and other proinflammatory signals, or they can shift to a more supportive state depending on what they detect from astrocytes and neurons.

⚡ Neurons suffer when inflammation rises
Oxidative stress, nitric oxide, and loss of metabolic support weaken them. Glutamate handling becomes impaired, which increases excitotoxic stress.

🧩 Oligodendrocytes and their precursor cells respond to what the environment tells them
Inflammatory signals slow their support for neurons, while regenerative signals encourage new myelin formation and better neuron stability.

The health of your brain depends on how these cells interact, not just on neurons alone.

doi: 10.1126/scitranslmed.adi7828

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

This project is funded by @agenceANRS

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Happy to start a new project aiming to design new therapeutical molecules to cross the human blood-brain barrier and able to target neuroflaviviruses. Coordinator of the NeuroFlaviNA project is Pr. Suzanne Peyrottes and involves the Pr. Fabien Gosselet of the @BBBLaboratory.

[Lab of Neuro Imaging @USCLONI]

On Tuesdays, we look at the hippocampus with vasculature ✌️🧠

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Avec un peu de retard, Félicitations à Cindy Nguyen pour la soutenance de sa thèse et l'obtention du grade de Docteur en Sciences ! 👏👏👏
Toute l’équipe du @BBBLaboratory est fière de la compter désormais parmi les docteurs 🥳 #Thèse #Doctorat #Recherche

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Le LBHE recrute des étudiants de Master 2 pour la période de Janvier à juin 2026. Envoyez vos candidatures au Directeur du Laboratoire (Pr. Maxime Culot) ou au Pr. Fabien Gosselet. N'hésitez pas à diffuser !

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

#EUInmyRegion #UEHDF #hautsdefrance

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Here we are! Following a few weeks of installation and training, the SMART platform at LBHE is proud to announce the arrival of our latest @Sciex zenoTOF 7600+ mass spectrometer coupled with a M Class-LC @Waters at the@Université d'Artois - Nord Pas de Calais.

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Let's begin our exciting journey into the worlds of proteomics and lipidomics. Thank you to everyone involved in this wonderful installation ! 😊
The ZenoTOF 7600+ project was co-funded by the European Union, the Hauts-de-France region, the CPER MOSOPS and the University Artois.

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Un immense bravo au Dr. Pietra Candela pour l'obtention de son Habilitation à Diriger des Recherches ! Une belle réussite pour un parcours riche, une implication constante et une passion communicative pour la recherche. Félicitations ! 👏👏

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

👏 Congratulations to Dr. Julien Saint-Pol winning the Best Oral Presentation at the 3rd International Electronic Conference on Cells !
A well-deserved recognition to support his research projects 🔬

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

👏Congratulations to our PhD student, Cindy NGUYEN, for being selected as one of the 12 regional finalists of #MT180!

📅 See you in Amiens for the regional final of the “Ma Thèse en 180 secondes” competition! 🎓🔥

🎥 Watch the event live on YouTube: https://t.co/DX1YQ1VUwQ

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

Join us for the IBBS Horizons Global Research Rounds featuring Prof. Dr. Norman Saunders, a pioneer in brain barrier research!✨

📢 Talk: "How did I get to here?"
📅 Date: March 4, 2025 (USA/Europe)
🕒 Time: | 9:00 PM (GMT) | 4:00 PM (EST)

https://t.co/6dn3y6nf0s

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

🤝Meeting of LBHE with the University of Batna 2 as part of the France-Algeria scientific partnership.
A great opportunity to collaborate on innovative research ! 🇫🇷🇩🇿

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

🧠 New study ! DHA, an essential fatty acid for the brain, may be better transported across the BBB through specific forms like LysoPS-DHA. These results open new perspectives in the treatment of neurodegenerative diseases. #Neuroscience

👉https://t.co/LQ63bzgFGK

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

📸Le LBHE au congrès SMAP Lille de la Société Française de Spectrométrie de Masse (SFSM) ! Un outil précieux dans la réalisation de nos projets !💡

[Labo de la Barrière Hématoencéphalique (LBHE) @BBBLaboratory]

🧠📢Our latest research on oxysterols is now published!
"25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain barrier breakdown in vitro"
https://t.co/sS73DD6Uwq

Well done to Rodrigo Loiola and Cindy Nguyen for their work ! 👏
#neuroscience