Lydia Freddolino

Science nerd working on microbial systems biology. University of Michigan associate professor in biochem and bioinformatics. Views are my own. 🏳️‍⚧️🏳️‍🌈

[Phyllis Hanson @PIHanson]

Exciting news – we’re hiring! Join our vibrant community, explore new frontiers in biochemistry, and mentor the next generation of scientific leaders.

For more information and application link see https://t.co/vEmY4lspCl

@UMich, @UMichMedicine, #UMichBiolChem

[Lydia Freddolino @beakerbreaker]

Our department (Biological Chemistry at the University of Michigan; #UMichBiolChem) is hiring! Details at https://t.co/OA2KiR7SBR -- we're looking for faculty at all ranks, and the department is really interested in further expanding our capabilities in computational biology.

[Phyllis Hanson @PIHanson]

Join the cutting edge of biochemistry - apply to University of Michigan Biological Chemistry’s PhD program!

https://t.co/ovNa939s5F

Great people, great science, great careers.
Applications accepted through Dec 1.

[Freddolino Lab @FreddolinoLab]

Come see us at #BPS2023! Peter will be presenting on large-scale structure/function predictions for annotating microbial proteomes (Room 5AB, 11:30 am today) and Ali will present on multiscale modeling of heterochromatin formation in fission yeast (Wednesday poster session, B169)

[Lydia Freddolino @beakerbreaker]

@AlbertVilella (Also, there was still substantive progress in the single chain predictions this year relative to CASP14, contrasting top groups this year to the vanilla AF2 and ColabFold predictions... as noted in the Rigden et al. slides, the targets this time were probably harder)

[Lydia Freddolino @beakerbreaker]

@AlbertVilella Interesting to compare with the plot from @Ezgi_Karaca_ showing the same sort of curves for multimer predictions, where we saw a big jump from CASP14 to CASP15

[Lydia Freddolino @beakerbreaker]

@EvolvingVir @FreddolinoLab Monomer predictions are D-I-TASSER (I-TASSER replica exchange simulations guided by threading and deep learning based potentials), multimeric are DeepMSAFold-multimer (extended MSAs guiding AlphaFold2-multimer). Papers coming soon. Slides at https://t.co/4TYYyHDua6

[Ezgi Karaca @Ezgi_Karaca_]

It's finally time to discuss the main highlights of #CASP15's assembly category, where we had these beatiful 41 targets:

[Freddolino Lab @FreddolinoLab]

Happy to share that our Michigan #CASP15 team ended up placing second in Regular Targets, first in Multimeric Targets, and first in Inter-domain prediction (1/3)