Karthikeyan Srinivasan

Consultant Anaesthesiologist, Asst Prof (UCD), ❤️‍🔥 Regional anaes, Past President of ISRA (2018-21),CEO and founder Gamtpedia ltd,

[Karthikeyan Srinivasan @beconscious247]

Clinical questions are easy. Turning them into a solid study plan is not.
SynapseR is built for that gap.
Not an “AI writes your protocol” tool.
A guided workflow:
Hypothesis → literature → endpoints → power → methods → SAP → draft protocol
https://t.co/YBFjiKWTa4

[Karthikeyan Srinivasan @beconscious247]

This is very interesting. I think like any other tool, using LLM indiscriminately can cause real cognitive regression. The answer is not to avoid using it but use it in a way that enhances your thinking skills.. The question is how do we do that?

[Elara Grace @ElaraGrace_AI]

🚨Just IN: If you've used ChatGPT for writing or brainstorming in the last 6 months, your creative ability may already be permanently damaged.

A controlled experiment just proved the effect doesn't reverse when you stop using it.

3,302 creative ideas. 61 people. 30 days of tracking.

Researchers split students into two groups. Half used ChatGPT for creative tasks. Half worked alone. For five days, the ChatGPT group outperformed on every metric. Higher scores. More ideas. Better output. AI was making them better.

Then day 7. ChatGPT removed. Every creativity gain vanished overnight. Crashed to baseline. Zero lasting improvement.

But that's not the bad part.

ChatGPT users' ideas became increasingly identical to each other over time. Same content. Same structure. Same phrasing. The researchers called it homogenization. Everyone using ChatGPT started producing the same ideas wearing different clothes.

When ChatGPT was removed, the creativity boost disappeared -- but the homogenization stayed. 30 days later, same result. Their creative range had been permanently compressed.

Five days of use. Permanent damage 30 days later.

A separate trial confirmed it. 120 students. 45-day surprise test. ChatGPT users scored 57.5%. Traditional learners scored 68.5%. AI reduces cognitive effort. Less effort means weaker encoding. Weaker encoding means less creative raw material.

You're not renting a productivity boost. You're financing it with your originality.

The interest rate is permanent.

[Karthikeyan Srinivasan @beconscious247]

https://t.co/PI1Tbn6Xwl

[Karthikeyan Srinivasan @beconscious247]

Combines:
• PubMed retrieval
• R-based power calculations
• EQUATOR frameworks (CONSORT/STROBE)
• Structured, versioned outputs
You still apply judgement. It just removes friction.
Free beta. Looking for honest feedback.
https://t.co/YBFjiKWTa4
#ClinicalResearch #MedEd #ai

[Karthikeyan Srinivasan @beconscious247]

Clinical questions are easy. Turning them into a solid study plan is not.
SynapseR is built for that gap.
Not an “AI writes your protocol” tool.
A guided workflow:
Hypothesis → literature → endpoints → power → methods → SAP → draft protocol
https://t.co/YBFjiKWTa4

[Peter H. Diamandis, MD @PeterDiamandis]

https://t.co/zbxWrGJa8o

[Karthikeyan Srinivasan @beconscious247]

@bcherny @ReadySetBrian Hi @bcherny I am a non coder and have been using 4.6 since it came out. 4.7 is way worse. Today is the first day I am going to bed without solving a bug. Had to roll back the app ota release update after 4 hours of non stop trying to fix it. Tomorrow will try 4.6

[ISRA @ISRA_Ireland]

Remember to join us for our workshops at the @coa_irl Congress 2026, details of each below!

Register at the following link: https://t.co/8Oa3r4ikXm

[Association of Anaesthetists @Assoc_Anaes]

New guidance on sterile gown use during spinal anaesthesia aims to reduce unnecessary waste while maintaining high standards of patient safety.

Consensus guidelines published in @Anaes_Journal now https://t.co/2gwiMJ3EVJ

With @RCoANews, @OAAinfo, @RegionalAnaesUK, CAI, ANZCA

[Karthikeyan Srinivasan @beconscious247]

Sterile gowns no longer mandatory for spinal anaesthesia !

[Dr Helgi @doctorhelgi]

Stop press: sterile gowns are no longer mandatory for spinal anaesthesia.

I’m so proud to have been part of this process trying to simplify our practice, making us more efficient, more sustainable without increasing risk to our patients.

https://t.co/JxQoNmkBql

[Karthikeyan Srinivasan @beconscious247]

@AlexFinn Running local models is good for product development. But for deployment we still need cloud right? So.what do you suggest is the best way to use open models in cloud for production? Llama?

[Rohan Paul @rohanpaul_ai]

Another great Robots in healthcare usecase.

Aletta is a robot that fully automates blood draws.

The patient sits down; the robot uses ultrasound to find a vein, helps position the arm, collects the sample, and applies a bandage—fully automated

[Karthikeyan Srinivasan @beconscious247]

@PeterDiamandis

Many economies rely heavily on labor as their primary competitive advantage — which AI directly erodes.

If labor value collapses globally before cost-of-living deflation arrives locally, do these countries risk getting structurally locked out of the upside?

[Peter H. Diamandis, MD @PeterDiamandis]

https://t.co/rXQ9oopPzJ

[Karthikeyan Srinivasan @beconscious247]

@alexwg @CorticalLabs are scaling through living neurons adapting in real time.
Do we actually understand the computational principles emerging in these networks yet — or are we still mostly observing and steering them empirically, like early neuroscience?

[Karthikeyan Srinivasan @beconscious247]

Purchased epiduo - Adapalene + benzoyl peroxide cream in #dublin - it was

95 euros!

Came to #India for a short visit- the exact same brand here is

9 euros!

Didn’t expect difference of 10x..

Sometimes the regulations and rules defy common sense!

[Karthikeyan Srinivasan @beconscious247]

Explore a new way to remember … you might be surprised ! #gamt #memory #learning #examprep

[Karthikeyan Srinivasan @beconscious247]

GAMT in 9 seconds !
For more info,

Website
https://t.co/oWiIxKsDaR

Webapp
https://t.co/iWVX9rCRgb

iOS
https://t.co/lkbJyYX4hH

Android
https://t.co/FuaEE8Qnk8

#gamt #learning #memory

[Karthikeyan Srinivasan @beconscious247]

#gamt #learning #memory

[British Journal of Anaesthesia @BJAJournals]

2025 DAS guidelines for the management of unanticipated difficult airway published today in the British Journal of Anaesthesia. #airway #difficultairway #intubation #anaesthesia #anesthesia

https://t.co/ieNnhhmbUw

[JAMA @JAMA_current]

📊 Research Summary: Personalized resuscitation targeting capillary refill time modestly improved organ support–free days and composite outcomes in early septic shock, but showed no difference in mortality vs usual care.

https://t.co/sNH2mm7RDq

[JAMA @JAMA_current]

Among patients with early #SepticShock, a personalized hemodynamic resuscitation protocol targeting capillary refill time was superior to usual care for the primary composite outcome, primarily driven by a lower duration of vital support.

#LIVES2025 @ESICM

https://t.co/UQH5mSw8Ty