Ben Shor

[PRX Life @PRX_Life]

This model uses #AlphaFold2-like architecture to perform flexible docking of small molecules into #protein targets, predicting both structure and affinity.

Read the paper: https://t.co/9sbF5ZeHC3

[Ben Shor @ben_shor]

"#CombFold: predicting structures of large protein assemblies using a combinatorial assembly algorithm and #AlphaFold" is now online in @naturemethods!
@DinaSchneidman

Read the paper: https://t.co/bA5IAQKdhq

[Ben Shor @ben_shor]

1/8 Excited to introduce CombFold - an algorithm for predicting large multi-protein complexes using the combinatorial and hierarchical assembly of #AlphaFold models. @DinaSchneidman
https://t.co/sW5gMgf8Ky

[Ben Shor @ben_shor]

@abs_WaleedM @DinaSchneidman Thanks! We do think it is very relevant, so we benchmarked CombFold against AFM and even the recently released AFMv3 (bars graph above in thread)

[Ben Shor @ben_shor]

1/8 Excited to introduce CombFold - an algorithm for predicting large multi-protein complexes using the combinatorial and hierarchical assembly of #AlphaFold models. @DinaSchneidman
https://t.co/sW5gMgf8Ky

[Ben Shor @ben_shor]

8/8 CombFold is available from https://t.co/Du0SBLFHsB and also as a Colab notebook. Please send us your feedback if you try it.

[Ben Shor @ben_shor]

7/8 Unknown stoichiometry remains one of the most significant gaps in high-throughput complex prediction. We present a proof-of-concept of using CombFold for rapid enumeration of stoichiometries.