(´_´ )bencho

Biologist trained in biochemistry, immunology, systems biology and cell biology. Nowadays I'm a mito guy. Love, Life and Earth...

[(´_´ )bencho @benchoboy]

Quisiera que l@s hij@s que no tengo aprendieran Linux desde el kinder 😭

[(´_´ )bencho @benchoboy]

@nacholozano @grok what is an incel? broader context, please.

[(´_´ )bencho @benchoboy]

@elonmusk De cuando Elon se privó de juicio histórico porque le salió un hijo put*. Y le rompieron todo el anillo a pesar de eso.

[(´_´ )bencho @benchoboy]

Un día, la América que le dicen "Latina" será recordada como la tierra bonita, la tierra prometida 🌎

[Gabriel Monteiro da Silva @GMondaSilva]

Thrilled to share that our study on the prediction of conformational ensembles and relative state populations w/ modified AlphaFold is out in Nature Communications!

The study has changed considerably since its debut as a pre-print, so go check it out!

https://t.co/r2vlqySdeW

[kzfm @fmkz___]

Rapid generation of high-quality structure figures for publication with PyMOL-PUB https://t.co/nNARD58BsT #bioinformatics #feedly

[Leonardo Rios @DrLeoRios]

Nice breakthrough! @Jnogales_SBG @polybiogroup @CIB_CSIC @susplast et al. have developed P. putida strains capable of converting plastics and lignin into up to 46% PHA/cell dry weight using a model driven approach #synbio #Sustainability @CellReports
https://t.co/F7tLNMIQK8

[Maarten van Smeden @MaartenvSmeden]

Your data may be missing
Your estimator may be biased
Your measurements may have errors
Your research question may be undefined
Your causal association may have residual confounding

Please don't worry

Your paper will be published

[Mushtaq Bilal, PhD @MushtaqBilalPhD]

ResearchGPT is a custom GPT especially designed for researchers.

It has a database of 282 million research articles and it answers your questions with references to published articles.

No fake citations.

Here's how to use it:

[Thomas Kole (see 🦋 and 🐘) @ThomasKoleTA]

a Portrait of Tenochtitlan, my 3D reconstruction of the capital of the Aztec Empire is released!

I've been looking forward to this for a long time, and I am really curious what all of you think.

Take a look:
https://t.co/31FSp9NBIm

#tenochtitlan

[Nature Careers @NatureCareers]

Not talking about #failures in #academia reinforces the idea that failure is both rare and disastrous – neither of which is true, says Anna Thompson, a biology #instructor @FeatherRiverCol. https://t.co/okfi2ABBB1

[CCG UNAM @ccg_unam]

El día de hoy se publica en la revista Science Advances un artículo que propone a un nuevo ancestro de la mitocondria. La investigación fue realizada por el grupo de trabajo de Mauro Degli Esposti, en colaboración con el @ibt_unam

https://t.co/MFAemvK82X

[Neuroskeptic 🇺🇦 @Neuro_Skeptic]

What would happen if you take all the output ChatGPT ever produced, and train a new GPT just on that. And then keep doing that over and over. Would it eventually degenerate into noise? Or become more complex?

[Svetlana Dodonova @Sveta_Dodonova]

Working on my poker game now only with the pretty PDB cards! Got a nucleosome straight flush! 😊😊 #PDB #goodsell

[Universum Museo @UniversumMuseo]

¿Conocías sus nombres? 😱

#Universum30 💙

[Niko McCarty. @NikoMcCarty]

Day 29/30 of great biology papers.

"Phylogenetic structure of the prokaryotic domain: The primary kingdoms," by Carl Woese & George Fox (1977).

Perhaps the most important paper in evolutionary biology. It established a "third domain" of life.
***

This paper is just 2.5 pages in length. It contains a single table as its figure. Its publication went largely unnoticed by biologists, but The New York Times printed a story about a "third type of life" on its front page.

Prior to this study, all life was divided into two categories: Cells that have a nuclear membrane (eukaryotes), and cells that don't (prokaryotes).

Francis Crick first proposed "comparing sequences to infer relationships" as early as 1958. But this paper heralded the dawn of molecular phylogenetics.

Woese and Fox claimed, provocatively, that "all cellular life falls into one of three large relatedness groups: eukaryotes...eubacteria, and archaebacteria."
(See https://t.co/JqGIpcfGJu)

They made this claim by sequencing a single, highly-conserved gene across many organisms: Ribosomal RNA. This is the catalytic part of ribosomes, the protein-making machines inside of cells. By studying how rRNAs had mutated over eons and eons, Woese and Fox inferred the evolutionary connections between cells.

Many well-regarded microbiologists at the time believed that the relationships between microbes could not be determined without a fossil record. This sounds hilarious in hindsight. But it was a real, mainstream belief.

Roger Stanier, who helped modernize microbiology and was a respected professor at UC Berkeley and the Pasteur Institute, wrote in his textbook, The Microbial World, in 1970:

"[r]eflection and experience have shown, however, that the goal of a phylogenetic classification can seldom be realized. The course that evolution has actually followed can be ascertained only from direct historical evidence contained in the fossil record. This record is at best fragmentary and becomes almost completely illegible in Precambrian rocks more than 400 million years old."

Overturning dogma and telling professors that they're wrong is fun! A classic.

One more day to go!

Paper: https://t.co/Phthq9tutl

[Mol Syst Biol @MolSystBiol]

Personalised whole-body human metabolic models integrating physiological, dietary & metabolomic data allow mechanistic exploration of host-#microbiome co‐metabolism --> https://t.co/POd2j8eilN
@ines_thiele @nuigalway @uni_lu #Metabolism #MetabolicModeling

[(´_´ )bencho @benchoboy]

@LuzSpica @revista_unam @cuartopisoton :)

[Carmina de la Luz (journA) 🇲🇽 @LuzSpica]

Con una emoción que no me cabe en el pecho 💓, les cuento que hoy se cumplió un sueño que tenía desde hace años: ser publicada por @revista_unam 📚. Gracias infinitas a Darío Alemán y a @cuartopisoton por la oportunidad y la edición 📝https://t.co/JaNatphx0S

[WIRED @WIRED]

“The bottom line is that shared escooters are currently damaging the climate.” (From 2022) https://t.co/GxrMxo0xLq