Ben Costa

Dad | Husband | Dentist 🦷

[Ben Costa @benevolentcosta]

@ChristofferBN @nicknorwitz Have a great day!

[Ben Costa @benevolentcosta]

@ChristofferBN @nicknorwitz Agreed that MR provides a clean natural experiment! The issue isn't whether MR is randomized, but whether a 60-year genetic exposure model can be used to numerically validate a 7-year drug trial curve. If duration makes them non-comparable Got to run out, but thanks for engaging!

[Ben Costa @benevolentcosta]

@ChristofferBN @nicknorwitz The results from short-term randomized trials are compatible with the very strong associations between LDL-C and cardiovascular events seen in Mendelian randomization studies."

[Ben Costa @benevolentcosta]

@ChristofferBN @nicknorwitz If taking a statin at age 50 isn't biologically equivalent to 60 years of genetic expression, then using Mendelian Randomization as the benchmark to validate 7-year drug trials is an apples-to-oranges comparison. If they aren't comparable, why use MR to justify the model?

[Ben Costa @benevolentcosta]

@ChristofferBN Or, if it really is just serum LDL-C driving the mortality reduction, why wouldn't the narrowing cholesterol gap lead to a narrowing benefit gap over time?

[Ben Costa @benevolentcosta]

@ChristofferBN If LDL-C levels between groups converge over time while the treatment group's relative benefit keeps growing, doesn't that point to non-cholesterol mechanisms (like statin pleiotropy or anti inflammatory effects) driving long-term protection?

[they call me Pencils @CindySinor]

My colored pencil drawing of berrylicious blackberries. ✍️🖤

[Olga Tuleninova 🦋 @olgatuleninova]

Emile Claus (Belgium 1849-1924)
Tree in the Sun (1900)
oil on canvas 184.5 x 151.8 cm

[DASHCAM @dashcammusic]

easy breezy

[Ben Costa @benevolentcosta]

@bindureddy agreed!

[斉藤 和 @saitoukazu]

天翔る。

[空に青。 @Sorani___Ao]

青を照らす夏が来る。

[Marysia @marysia_cc]

Kawase Hasui
Boshu Kamo River, 1934

[Marysia @marysia_cc]

Pia Valentinis

[Museum @DailyClassicArt]

Akseli Gallen-Kallela - "Spring Night" (1914)

[Dan Berthod @DanBerthod]

Félix Vallotton
Coucher de soleil, 1913

[Dan Berthod @DanBerthod]

Edvard Munch
Dance on the Beach, c.1900

[The Art Curator @SeekAfterBeauty]

From Reine in Lofoten (1880), by Adelsteen Normann