Ben Goult

Talin as a memory molecule #MeshCODE. Talin shock absorbing materials #TSAM. Prof at @LivUniISMIB Hobbies: Mechanobiology, talin, looking at the sky

[Ben Goult @bengoult]

Excited to share our new study @biorxivpreprint

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵the paper is summarised in this video.

https://t.co/wV3GGokTLV

[Ben Goult @bengoult]

Excited to share our new study @biorxivpreprint

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵the paper is summarised in this video.

https://t.co/wV3GGokTLV

[Ben Goult @bengoult]

Brilliant work led by Yasumi Otani in the lab, Neil Ball, and great collaborations with Emily Goodall and @zech_lab Tobi Zech, and Vignesh Srinivasan and @SaarikangasLab

[Ben Goult @bengoult]

Excited to share our new study @biorxivpreprint

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵the paper is summarised in this video.

https://t.co/wV3GGokTLV

[Ben Goult @bengoult]

https://t.co/K3Qn3z9Tbq CDKL5 is an essential kinase in the brain, and mutations in the CDKL5 gene cause a devastating childhood epilepsy condition, called CDKL5 Deficiency Disorder (CDD).

[Vasso Kostourou @KostourouVasso]

At the end of a challenging year, in collaboration with Tamar Harel, Naama Elephant, @bengoult, we found a #Talin 1 mutation that is genetically associated with #SCLS and affects#endothelial #permeability linking #cell- #ECM adhesion to #adherens Junction https://t.co/7UD90TpMdJ

[Ben Goult @bengoult]

Our new paper on pathogenic Talin1 mutants that cause Systemic Capillary Leak Syndrome :)

[Bidone Lab @tamarabidone]

Excited to share our latest paper, now published! Huge congratulations to @kolasangiani , PhD student in @UtahBME and @uusci, for his outstanding work. Check it out here: https://t.co/AhGzFeRIlH

#Research #BME #PhD #NewPublication

[Ben Goult @bengoult]

Exciting project with co-PIs, @xlinkx_pd and @PaulIAtherton at @LivUniISMIB and @MJ_Humphries
at @wtccmr

[Ben Goult @bengoult]

*Fully funded PhD position available in the lab*

We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation.

Please RT, and email/message for details
https://t.co/3TG8MxHf0J

[Ben Goult @bengoult]

"Adhere2 will follow the same format as Adhere1. There will be no invited speakers, except for the plenary speaker, supported by EMBO. Instead, Adhere2 will determine its own content based on contributions from those who attend."
This model worked great :)

[Ben Goult @bengoult]

Look at the amazing speaker list for Adhere2 next September!
This is going to be an excellent meeting, in beautiful Zadar, Croatia.

https://t.co/o6u0LywicO

[Ben Goult @bengoult]

"Mechanical switches and protein meshes – this is a new way of looking at one of our most feared diseases."

[IFLScience @IFLScience]

A Shapeshifting Protein Is Leading Alzheimer’s Disease Researchers Down A New Path
https://t.co/bGak3aQGy1

[University of Liverpool News @livuninews]

NEWS | A new study represents a significant step forward in understanding #Alzheimer’s.

Investigators examined two proteins found in the brain and suggest the stability of their relationship is crucial for memory formation⬇️

https://t.co/DR4lB3VYTO

[Ben Goult @bengoult]

the story is summarised in this 20 second animation.
https://t.co/O5zK9GfQfz

[Ben Goult @bengoult]

Very excited to share our new paper on Talin binding to Amyloid Precursor Protein indicating a new way to think about Alzheimer's Disease.

It has the most provocative discussion section we have ever written :)

https://t.co/MfJtvQ91Db

[Ben Goult @bengoult]

Great work by Charles Ellis, Natasha Ward, Matthew Rice and Neil Ball, with excellent collaboration for the cellular neuroscience work by Pauline Walle, Chloe Najdek, Deverim Kilinc, Jean-Charles Lambert and Julien Chapuis at Institut Pasteur de Lille.

[Ben Goult @bengoult]

Press release on our new paper linking talin to amyloid precursor protein (mis)processing indicating that there is a mechanical basis of Alzheimer's disease. https://t.co/ARWGi3fH99 @LivUniResearch @UniKent @PasteurLille

[Ben Goult @bengoult]

@elinorchapman 👀

[J Cell Science @J_Cell_Sci]

Our Special Issue on Imaging Cell Architecture and Dynamics is now complete.
You can explore our ToC here: https://t.co/g2KJ1QT5yM
‘Breaking symmetry’ from @AntaraC9 was the winning image from our cover competition with @focalplane_jcs. The image is a MEF labelled with phalloidin (green), acetylated tubulin antibody (magenta) & DAPI (blue).

[Warwick Dunn @rickdunnblade]

Want to develop your career in cancer metabolomics in a leading lab? 5 year @CRUKresearch post-doc position available in @rickdunnblade group. Come work in Liverpool. Info available at https://t.co/Rnoumw6pXI. Please repost.