JoJo Benn

Postdoc with @w_mcewan at @ukdri Cambridge. Developing targeted protein degradation strategies against neurodegenerative protein aggregates.

[JoJo Benn @benn_jojo]

Very happy to share our paper describing the selective degradation of aggregated tau protein via clustering activated RING-Nanobody (R-Nb) constructs.

Intracellular R-Nb expression prevented tau aggregation and rapidly removed preformed aggregates.

https://t.co/ufbwMB1kqA

[Joe Money @JM_EcoEvo]

Check out episode 9 of The ParAqua Podcast featuring @jo_mauch from @LeibnizIGB
We discuss his PhD research into the effects of climate change and changing lake ecology on the invasive Quagga Mussel
https://t.co/NTo91Fvlfd @ParAqua_CA20125

[Jennifer Palmer @JenniferEPalmer]

Our review is out now in @NeuroCellPress! We provide an updated overview of the links between autophagy, ageing, and age-related neurodegeneration. A collaboration between the Rubinsztein and @VIKorolchuk labs that was very enjoyable to work on 🤓
https://t.co/rygzwhhOfJ

[Joe Money @JM_EcoEvo]

Episode 8 of the ParAqua podcast features Professor Claire Gachon from the Museum of Natural History in Paris. We discuss her research on parasitism and the impacts it can have on the emerging algal aquaculture industry
https://t.co/NTo91Fvlfd
@ParAqua_CA20125 @AnaAgavrilster

[Alzforum @alzforum]

Targeting intracellular tau tangles with the active domain of a ubiquitin ligase mopped them up rapidly in tauopathy mice. #alzheimersdisease @UKDRI, @MRC_LMB https://t.co/TWhBvIeJ8g

[UK Dementia Research Institute @UKDRI]

Exciting new research co-led by @w_mcewan harnesses the unique capabilities of the protein TRIM21 to selectively remove aggregated tau from the brains of mice

The team say this approach could avoid any potential side-effects of eliminating normal tau👉https://t.co/JDVYjtLTrE

[UK Dementia Research Institute @UKDRI]

The UK DRI's @w_mcewan & @JamesLab9 (@MRC_LMB) have developed new therapies that selectively remove aggregated tau proteins - harnessing the unique capabilities of a protein called TRIM21.

The treatment improved symptoms of neurodegeneration in mice👉https://t.co/JDVYjtLTrE

[Inside Precision Medicine @Inside_PM]

Researchers from @MRC_LMB in Cambridge, England and @UKDRI at @Cambridge_Uni have developed new potential therapies that selectively remove the aggregated tau tangles to treat #Alzheimersdisease. Learn more: https://t.co/3gKRki3uED

[Guido Papa @guidovir_]

Super excited to share our latest paper on a novel targeted protein degradation technology, now out in @CellCellPress. We introduce RING-Bait technology, an innovative approach to selectively target and degrade intracellular protein aggregates (1/7) https://t.co/9VZY4fVtzX

[JoJo Benn @benn_jojo]

It's been a long journey from TRIMinator to R-Nb, and wouldn't have been possible without the expertise of my co-first author Shi Cheng and the support of @w_mcewan and the many others involved in this project!

[JoJo Benn @benn_jojo]

Very happy to share our paper describing the selective degradation of aggregated tau protein via clustering activated RING-Nanobody (R-Nb) constructs.

Intracellular R-Nb expression prevented tau aggregation and rapidly removed preformed aggregates.

https://t.co/ufbwMB1kqA

[JoJo Benn @benn_jojo]

We've focused on tau, but hope that the growing repertoire of nanobodies will allow for the creation of R-Nb's against the many other aggregating proteins implicated in neurodegenerative disease!

[Sophie Sanford @_sophiesanford]

Enjoying Gothenburg before #ADPD2023! Fantastic to be here and see some sun too 😄

@w_mcewan lab and friends @UKDRI 🤩

[JoJo Benn @benn_jojo]

@Ddotpoi I'd completely forgotten this traumatic event lol

[Annabel Smith @Annabel_E_Smith]

Great few days with the McEwan lab at ADPD2022 - hope to be back next year! #TogetherAtADPD

[JoJo Benn @benn_jojo]

@cdawg1234569 What's the matter? Getting tired?

[JoJo Benn @benn_jojo]

@JoeMoneyVII @BBCRadioLincs @RAFConingsby @giantpoppywatch Can't believe they're not called Britishfighter Typhoons 😤😤

[JoJo Benn @benn_jojo]

@charliejenks_95 This was his answer when I asked why we don't have a microwave