Christian Benner

Statistician during daytime…

[Satoshi Koyama @skoyamamd]

Excited to share our latest manuscript in @NatureGenet! Utilizing high-resolution genetic data imputed with a population-matched reference panel, we uncovered causal genetic variants for a wide range of human traits over 200K participants from Japan (1/20)
https://t.co/gYThPqMe59

[Taru Tukiainen @ttukiainen]

Check out our latest findings on X-inactivation in iPSCs now out in Genome Biology https://t.co/SWpIukchnB A great collaboration with Dr Olli Pietiläinen and a cool demonstration of the many complexities of the X chromosome 😎

[Samuli Ripatti @samrip]

Matti’s course is a 💎

[Matti Pirinen @MattiPirinen]

Work with us as postdoc in statistics / statistical genetics at University of Helsinki @helsinkiuni @FIMM_UH Apply by 21.5.
https://t.co/x3ONejZfMp

[Fulong Yu @fulong_yu]

Extremely excited to share our work on #V2F method SCAVENGE for the disease/trait relevant causal cell type/state identification using single-cell epigenomic data https://t.co/rD9vl71LNE out now in @NatureBiotech. The R package can be found https://t.co/snBR3Fqi4o.

[Christian Benner @bennerstat]

@gavinband Yes, it’s annoying. Maybe brew gcc8 and symbolic link would work?

[Jian Yang @jyang1981]

Apart from COJO, FINEMAP also benefits substantially from DENTIST-based QC when an external LD ​​reference is used.
https://t.co/fSwBRfNNJw

[Claudia Calabrese @Claudia20755263]

Our UK Biobank mito-phewas is finally out! Great collaborative work. Congrats to @DoingYonova, Dr. Jo Howson, @auroradevea et al. Exciting times ahead for mitochondrial genomics! @cam_mito
https://t.co/e6tm8h5GA5

[Taru Tukiainen @ttukiainen]

Excited to share this preprint from the lab led by my talented postdoc Jaakko T. Leinonen (not on Twitter) where we used both UK Biobank and FinnGen data to comprehensively profile the role of testosterone in human health and disease. Thread 👇https://t.co/hbvKa1K71W

[Samuli Ripatti @samrip]

Our paper (led by Pyry Helkkula & Ida Surakka) on lipid associated pLoFs and their impact on cardiometabolic risk is now out. Leading the pack is 80-times Finnish enriched PTV in ANGPTL8 gene. @PLOSGenetics @CoECDG @FinnGen_FI @FIMM_UH

https://t.co/PdnvgDWDco

[Jeremy Schwartzentruber @jschwart37]

In our new paper we do in-depth follow-up of Alzheimer’s disease GWAS: integrating fine-mapping, colocalization, gene network analyses, and single-cell gene expression to prioritise risk genes. This figure would have better represented the work.

[Yosuke Tanigawa @yk_tani]

With FINEMAP, we identified >27,000 distinct signals in >5,000 regions across the 35 traits, of which >2,500 signals were fine-mapped to a single variant. We also trained sparse polygenic risk score (PRS) models with Lasso L1- penalized regression using the snpnet package. (4/n)

[Mauro D’Amato @damato_mauro]

our hemorrhoids GWAS preprint is out, almost 1 M people studied! 1st time the genetic architecture of this trait is investigated, we detect 102 loci that point to smooth muscle, epithelial and connective tissue dysfunction
with @an_franke and many others
https://t.co/ocAQICR9xJ

[Christian Benner @bennerstat]

👍🏻

[Omer Weissbrod @oweissb]

Finally, this was a great team effort w/ Alkes Price, @FHormozdiari, @bennerstat, @julirsch, @StevenGazi, @Luke0connor, @MattiPirinen, and many other brilliant people not on Twitter (and requiring >280 chars). Thanks everybody!

[Christian Benner @bennerstat]

@oweissb Yes and wrote a paper about that already in 2017 recommending sharing of LD information https://t.co/EdTuui3UOq

[James Walters @drjameswalters]

Here we go. The PGC Schizophrenia GWAS (phase 3) paper in preprint. A massive group effort and thanks to participants and researchers internationally. Also special mention to SCHEMA colleagues and the papers bear reading alongside each other. https://t.co/dxl7O94U9S

[Christian Benner @bennerstat]

@masakanai @andganna @jcbarret @ewanbirney @dvh13 @covid19_hgi @EastLondonGenes @BradfordGenes Assuming a single causal variant. Is the zoomplot not showing a likely second signal? What about getting in-sample LD for HOSTAGE_EUR,
UKBB_EUR (which you have already) and GENCOVID_EUR as a start?

[Christian Benner @bennerstat]

@jcbarret @ewanbirney @dvh13 @covid19_hgi @EastLondonGenes @BradfordGenes @andganna Quite a few studies to collect in-sample LD information for proper fine-mapping. However it’s one locus. Any plans/help needed @andganna?

[Eric Fauman (he/him) @Eric_Fauman]

You have a GWAS SNP.

Great.

Now, what's the causal gene?
Really excited to share this preprint with coauthors Vince Forgetta and Lai Jiang, @BrentRichards19 , @markmccarthyoxf , @Greenwood_LDI and others

https://t.co/wNnDFwum8X