Min Qian, Matthew Cummings, David Zhang, Shing Lee, Jeremy Beitler, Jo Applebaum, Edward Schenck, Hassan Mohamed, Richard Trepp, Hanson Hsu, Jean Scofi, Will Southern, Sarah Rossetti, RN, PhD, Natalie Yip, Dan Brodie, Manish Sharma, Baruch Fertel, @JasonAdelmanMD
Excited to share our protocol paper in BMJ Open describing the SEPTIC trials — pragmatic, multicenter RCTs testing whether interruptive SIRS-based EHR alerts improve timely sepsis care. And will be even more excited to share the trial results shortly.
https://t.co/u2BuoupXLM
We aim to answer two key questions:
✅ Do these alerts improve sepsis care?
✅ Who should receive them?
Huge thanks to our amazing collaborators across @Columbia , @WeillCornell , @nyphospital and more!
These observations are based on mathematical modeling. Data from patients and additional research are needed to confirm these findings. Also, we did not model immunosuppressed patients.
In the mean time, please follow the advice of your doctor and take Paxlovid as directed!
6/6
Our modeling shows longer duration of Paxlovid treatment does not prevent rebound. Initiating Paxlovid treatment a few days later (a few days after symptom onset) does prevent rebound. However, the patient's immune system is already clearing the virus at this point.
5/6
In conclusion, patients hospitalized with #covid19 with sudden cardiac death had lower RMSSD and smaller adrenal gland size than patients who died without sudden cardiac death. These exploratory findings need to be replicated in other cohorts.
We also wondered whether adrenal insufficiency could be playing a role in the sudden cardiac death. Adrenal size was significantly smaller in the sudden cardiac death group (while all other organ weights were similar).