Benjamin Ranard

Intensivist at @ColumbiaMed | Learning Health Systems and Health IT | Formerly @DukeMedicine @PennMedicine @Penn_MSHP @Cornell

[Benjamin Ranard @benranard]

Min Qian, Matthew Cummings, David Zhang, Shing Lee, Jeremy Beitler, Jo Applebaum, Edward Schenck, Hassan Mohamed, Richard Trepp, Hanson Hsu, Jean Scofi, Will Southern, Sarah Rossetti, RN, PhD, Natalie Yip, Dan Brodie, Manish Sharma, Baruch Fertel, @JasonAdelmanMD

[Benjamin Ranard @benranard]

Excited to share our protocol paper in BMJ Open describing the SEPTIC trials — pragmatic, multicenter RCTs testing whether interruptive SIRS-based EHR alerts improve timely sepsis care. And will be even more excited to share the trial results shortly.
https://t.co/u2BuoupXLM

[Benjamin Ranard @benranard]

We aim to answer two key questions:
✅ Do these alerts improve sepsis care?
✅ Who should receive them?

Huge thanks to our amazing collaborators across @Columbia , @WeillCornell , @nyphospital and more!

[Benjamin Ranard @benranard]

@Crazymoments01 @elonmusk N

[Benjamin Ranard @benranard]

These observations are based on mathematical modeling. Data from patients and additional research are needed to confirm these findings. Also, we did not model immunosuppressed patients.

In the mean time, please follow the advice of your doctor and take Paxlovid as directed!

6/6

[Benjamin Ranard @benranard]

We created a mathematical model of SARS-CoV-2 immunity that looks at "Paxlovid Rebound"

https://t.co/SNtVWbNb32

@ccc1685 @m_datasci @Prof_Shadnaz @soojin_soojin @yoram66

#PaxlovidRebound #Paxlovid #COVID19 #COVID

1/6

[Benjamin Ranard @benranard]

Our modeling shows longer duration of Paxlovid treatment does not prevent rebound. Initiating Paxlovid treatment a few days later (a few days after symptom onset) does prevent rebound. However, the patient's immune system is already clearing the virus at this point.

5/6

[Joel Boggan @JoelBoggan]

Out @JHealthQuality: #pophealth didactics ⬆️confidence on team-based care strategies but translating to ⬆️ #health outcomes likely req #QI efforts across residency training

@Duke_GIM @IMResidencyDuke #DukeOutpatientClinic @JPShoup @azaleakim @benranard

https://t.co/vZjik9oTsY

[Benjamin Ranard @benranard]

In conclusion, patients hospitalized with #covid19 with sudden cardiac death had lower RMSSD and smaller adrenal gland size than patients who died without sudden cardiac death. These exploratory findings need to be replicated in other cohorts.

[Benjamin Ranard @benranard]

Out today, our work: heart rate variability and adrenal size provide clues to sudden cardiac death in hospitalized #COVID19 patients

https://t.co/XVmQ4vDgFP

@soojin_soojin @m_datasci @kalijahterilli @Hirad7 John Ausiello

@ColumbiaMed @nyphospital @CU_Cardiology

[Benjamin Ranard @benranard]

We also wondered whether adrenal insufficiency could be playing a role in the sudden cardiac death. Adrenal size was significantly smaller in the sudden cardiac death group (while all other organ weights were similar).