Conor Walker

Bioinformatics Scientist.
Formerly postdoc at @nygenome/@Columbia and PhD @emblebi/@Cambridge_Uni.

[Gamze Gürsoy @gamzeandgursoy]

Super excited to share my lab's latest work on quantifying the private information leakage from single cell count matrices. Led by very first postdoc in the g2lab, brilliant @BioConorWalker, we showed that individuals can be reidentified 1/n https://t.co/q9R60SvdV3

[Anoushka @noush_joglekar]

If you were looking for evidence that isoforms are cool, all-pervasive in the 🧠, and everybody should study them at the single cell level, our work on mouse development and brain-region variability from the @hagentilgner lab is now live @NatureNeuro! 1/

https://t.co/VUJlSu979C

[Nicola De Maio @Nicola_De_Maio]

A few months ago we posted a pre-print regarding a new approach to likelihood-based phylogenetics at short divergence scales (e.g. genomic epidemiology). I have now further optimized the code and updated the preprint https://t.co/K8chTGu9cS

[Erik Garrison @erikgarrison]

We've made a draft human pangenome! 47 haplotype-resolved assemblies, two reference genomes, and five pangenome graphs!

[Shai Carmi @ShaiCarmi]

This is a brilliant preprint. It describes an experimental method for separately sequencing the paternal and maternal genomes. This goes beyond the standard "experimental phasing" - the method can also tell which chr is maternal and which is paternal.

https://t.co/zZpHVLrvr2

[Hakhamanesh Mostafavi @Hakha_Most]

We've known for a long time that a large fraction of noncoding GWAS hits are not currently explained by eQTLs. Why?? I'm excited to share our new preprint on this! Take home: GWAS and eQTL assays maximize power for different types of variants. (1/n)

https://t.co/JUFXnE7zLU

[Zamin Iqbal @ZaminIqbal]

Groundbreaking work from @Nicola_De_Maio @EBIgoldman and colleagues
"we rewrite the classical Felsenstein pruning algorithm so that we can infer phylogenetic trees on at least 10 times larger datasets with higher accuracy than existing maximum likelihood methods. "

[Mat Legut, PhD @MatLegut]

Really chuffed to share our latest work from Sanjana Lab out in @nature today (https://t.co/skHTGrKACw).

We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.

A thread...

[Conor Walker @BioConorWalker]

A huge thank you to @Nick_Goldman, @aylwyn_scally, @Nicola_De_Maio, and members of @EBIgoldman for their supervision and support during my #PhD.

[Conor Walker @BioConorWalker]

Looking forward to starting my new position with @gamzeandgursoy at @nygenome! I will be working on developing methods for genomic #privacy.
https://t.co/vPJQxSCDNT

[Goldman Group @EBIgoldman]

Simulating pandemic-scale genome sequencing datasets, e.g to benchmark your new analysis methods? Try phastSim, now updated to include indels (https://t.co/4V9xAf2qEm)
[1/2]

[josé @zga_aaa]

Glad to see this out. Here, we track ~700 clones across >300 individuals over ~13 years to unravel key aspects of clonal haematopoiesis (when there are genetically-defined subpopulations of haematopoietic stem cells in your bone marrow).

[EvolCompGen @EvolComp]

Congrats to the 2021 @EvolComp Talk & Poster awardees for #ismbeccb2021

Best talk - Elise Parey (@CamLBerthelot lab)

Best poster - Vignesh Sridhar (@Vigs_24, @JRaviLab)

Honorable mentions
Talks -
@punto_c
@BioConorWalker
@matteodelabre
Posters - @elliotmajlessi

[Goldman Group @EBIgoldman]

We are still looking to hire a postdoc bioinformatician on this fascinating project. Please read/RT/pass on to anyone who might be interested:
https://t.co/dkTNhOfVdF

[Goldman Group @EBIgoldman]

We are re-advertising this position! Please check-out 👇 the original thread 👇, pass to anyone you think might be interested, share with colleagues, RT ...
https://t.co/02VoSI3GAO

[Goldman Group @EBIgoldman]

The impressively huge scale of SARS-CoV-2 sequencing has really stretched our ability to do phylogenetics, and is leading to some fantastic advances in methods. Here's one that @Nicola_De_Maio from the @EBIgoldman group at @emblebi contributed to.
https://t.co/SlqtnTsD1H

[Goldman Group @EBIgoldman]

Last call; closing date on Monday. Please apply! If you don't apply, at least promise me you'll RT or pass to a friend.
https://t.co/02VoSI3GAO

[Goldman Group @EBIgoldman]

Postdoc position in @EBIgoldman Group at @emblebi, to join new multinatl collab project creating proof-of-principle high-throughput nanopore device for determining amino acid sequence and identity of proteins

Full details at https://t.co/2FTwXNrn6G

<1/2>

[Conor Walker @BioConorWalker]

@Nicola_De_Maio @uperron3 In Too Deep for sure... also maybe Break Stuff

[Goldman Group @EBIgoldman]

For those of you who love to explain complex mutation clusters parsimoniously (who doesn't?), the final version of @BioConorWalker's paper is now out at https://t.co/aRHLjXKkh4 - also feat. @aylwyn_scally and @Nicola_De_Maio. And me. Cool figures too: this 👇 is part of S.Fig 10