biotekman

[秦悦乐 @QinYueLe]

徐飞洪，中国驻印度大使
毕业于武汉大学
满族人

就是他拍板的，开放K签
大量引进印度移民
7311“人口净化”计划实施者

[Massimo @Rainmaker1973]

Life is not about what happens to you, but what you do with what happens to you.

[biotekman @biolabpartner]

人口紅利陷阱 印度經濟走退路?! https://t.co/BaoGKuBeVo 来自 @YouTube

[James Wood 武杰士 @commiepommie]

Today I wandered Urumqi (Xinjiang's capital) and local non-tourist streets. I made a clear firsthand observation: Uyghur residents are everywhere, going about their daily lives. Men wear traditional doppa hats, women wear yashmaq, and the Uyghur language is spoken everywhere.

I captured many videos of every district and market I visited and I plan to publish once I have time to edit them.

In the meantime, here are a few photos of the Grand Bazaar.

[王局拍案 @wangjupaian]

【耿同学，又出山啦，这次朝他的母校北航开火】

6月16日，耿同学讲故事发视频：北航副院长，杰青，Nature论文，数据批量造假！

6月17日，耿同学讲故事又发视频——院长硬刚网友！神狡辩：官网数据没错，只是我藏了更多！

[biotekman @biolabpartner]

@commiepommie Thanks for your objective appraisal and friendly applause.

[王局拍案 @wangjupaian]

【西湖大学学费引热议：内地生6000元，留学生35万元】

5月31日，西湖大学公布2026年本科收费标准。其中，内地学生学费为每年6000元，外籍留学生学费为每年35万元，两者相差约58倍。

消息引发热议，有网友评其“硬气”“清醒”。

[John Lukens @LukensJohnR]

Microglia-dependent regulation of fear memory extinction
https://t.co/PgsfzXmocB

[오창명 @changmyung1981]

Neurodegeneration Is a Systems Failure — Not Just Neuron Loss

For decades, brain diseases like Alzheimer’s were framed as a linear story: neurons accumulate toxic proteins, then die. But converging evidence across high-impact studies suggests a different model — one that is far more integrated, and clinically actionable.

A recent study in Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.2516601123) demonstrates that during sleep, neural slow waves, vascular oscillations, and cerebrospinal fluid (CSF) flow are tightly coupled. This coordinated system drives glymphatic clearance — effectively a “wash cycle” for the brain. Disruption of this coupling may impair the removal of metabolic waste, including amyloid-β, linking sleep physiology directly to neurodegenerative risk.

At the cellular level, a landmark atlas published in Science (DOI: 10.1126/science.adf6812) reveals that vulnerability in the human brain is highly cell-type specific. Rather than uniform degeneration, distinct neuronal subpopulations exhibit selective susceptibility depending on their molecular identity, metabolic state, and anatomical context. This reframes neurodegeneration as a problem of selective circuit failure, not global decline.

Meanwhile, vascular integrity is emerging as a central determinant of disease progression. Work in Nature Medicine (DOI: 10.1038/s41591-023-02523-3) shows that aging is associated with breakdown of the blood–brain barrier (BBB), enabling peripheral immune cells and inflammatory mediators to infiltrate the central nervous system. This creates a feed-forward loop of neuroinflammation, exacerbating neuronal dysfunction.

Finally, synaptic loss — not neuron death — appears to be the earliest pathological event. Evidence from Nature Neuroscience (DOI: 10.1038/s41593-022-01186-2) indicates that activated microglia mediate excessive synaptic pruning through complement pathways. This process dismantles neural circuits before neurons themselves are lost, suggesting that functional decline begins much earlier than previously thought.

Taken together, these findings support a unifying framework: neurodegeneration arises from the breakdown of an interconnected system involving clearance mechanisms, vascular integrity, immune regulation, and synaptic maintenance.

This shift has profound therapeutic implications. Interventions targeting sleep architecture, glymphatic flow, BBB stability, and microglial activation may be more effective than neuron-centric strategies alone. Protecting the system — rather than just the cell — may be the key to altering disease trajectory.

Selected References
DOI: 10.1073/pnas.2516601123
DOI: 10.1126/science.adf6812
DOI: 10.1038/s41591-023-02523-3
DOI: 10.1038/s41593-022-01186-2

[nature @Nature]

Geneticist J. Craig Venter, best known for his role in sequencing the human genome, has died aged 79.

He spoke to Nature in 2023 about AI, sequencing the ocean – and why he had no plans to stop working.

https://t.co/FYq5jbMpxa

[Massimo @Rainmaker1973]

A landmark study from UT Southwestern Medical Center and Texas Health Resources shows that consistent exercise can literally turn back the clock on sedentary aging of the heart.

In the two-year randomized controlled trial, previously sedentary middle-aged adults (ages 45–64) who exercised four to five times per week experienced remarkable improvements: an 18% increase in maximum oxygen uptake and a more than 25% improvement in the elasticity (compliance) of the heart’s left ventricle — the chamber responsible for pumping oxygen-rich blood throughout the body.

The structured program combined moderate-intensity aerobic workouts, high-intensity interval training, and strength exercises. This “dose” of exercise proved far more effective at restoring cardiac function than lower-intensity activities like yoga or balance training alone.

Lead researcher Dr. Benjamin Levine emphasizes that exercise should be viewed as essential daily “hygiene” for heart health to help prevent future heart failure. Importantly, the heart retains significant plasticity to reverse stiffness only when this active lifestyle begins before age 65. Starting later appears to offer little benefit.

Published in the journal Circulation, these findings provide a powerful, evidence-based roadmap for middle-aged adults to reclaim their cardiovascular health and undo years of damage caused by a desk-bound lifestyle.

[Levine, B. D., et al. (2018). Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial: Implications for Heart Failure Prevention. Circulation]

[biotekman @biolabpartner]

@bbjk666 有长寿基因

[biotekman @biolabpartner]

李敖:提醒大家這仗不能打! #李敖 #賴清德 #民進黨 https://t.co/U6HBGeDd3k 来自 @YouTube

[biotekman @biolabpartner]

@ALVtomoon @wangjupaian 回归后，饭碗没了

[biotekman @biolabpartner]

@AtwoodJian @yangyangnupeng1 SB

[Steven Ge @StevenXGe]

New in iDEP: label your k-means clusters with enriched pathways—just a few clicks. Try it on your RNA-seq data today: https://t.co/n7uemh7fLw

[biotekman @biolabpartner]

@nfsc999 医生？免疫学机理都搞懂了了吗？

[Rare 🇺🇸 @RareImagery]

Scary movies!

[biotekman @biolabpartner]

@USA_China_Talk @SecRubio 以前贸易不公平？那你们以前怎么不阻止呢？

[顾清音 @qing_yin19640]

中国女性发型的百年变迁