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to reverse a rare life-threatening immune condition called leukocyte adhesion deficiency in nine children.⁠ ⁠

#genetherapy #medicine #health #biology

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Gene-replacement therapies are used to correct genetic disorders that are caused by mutations in a single gene that stop it from working properly. They involve inserting new, working copies of the gene into relevant cells, typically using a virus as a carrier.⁠ ⁠

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“We’re curing kids of fatal diseases. It’s wonderful,” Donald Kohn at the University of California, Los Angeles told New Scientist team in May after successfully using a gene-replacement therapy

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#botany #plants #biology
#bioscoolya #biotechnology #scoolya #science #sciencenews #lifescience #LifeSciences

[BIO SCOOLYA @bioscoolya]

Researchers at UC San Diego, USA, have discovered that plants use a two-protein system to regulate the opening of the stomata.⁠⁠In low CO2 environments, the protein, HT1, activates an enzyme which force guard cells to keep stomata open.

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When CO2 concentration increases inside the plant, a second protein blocks the HT1 pathway.⁠⁠

Journal :
Stomatal CO2/bicarbonate sensor consists of two interacting protein kinases, Raf-like HT1 and non-kinase-activity activity requiring MPK12/MPK4

DOI: 10.1126/sciadv.abq6161